Association Between Oxidative Stress and Peripheral Leukocyte Telomere Length in Patients with Premature Coronary Artery Disease

Tian, Ran; Zhang, Lei-Nan; Zhang, Tingting; Pang, Haiyu; Chen, Lianfeng; Shen, Zhujun; Liu, Zhenyu; Fang, Quan; Zhang, Shuyang

doi:10.12659/msm.902106

Cited by 31 publications

(27 citation statements)

References 27 publications

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“…Previous studies showed there were cases of shortening of telomere length in patients with CHD in both Caucasians [26, 27] and Asians [28, 29]. A study examined the LTL by 1525 postmenopausal women and indicated that LTL was closely related to human race.…”

Section: Discussionmentioning

confidence: 99%

Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis

Lin

et al. 2019

BioMed Research International

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Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. However, the reported results are not consistent, since the experimental design method, the measurement method, and the disease outcome are different. Therefore, we searched five major literature databases (Pubmed, Web of science, Embase, CNKI, and Wangfang) and finally included 18 eligible articles (including 5,150 patients with CHD and 9341 controls). We found that telomere length in patients with CHD was significantly shorter than that in controls, and the telomere length was inversely correlated with the severity of CHD. Subgroup analysis showed that telomere shortening was the most significant in Asian patients with CHD, in CHD patients with an average age <65 years, and in men with CHD. The mechanism of shortening the telomere length leading to the occurrence and development of CHD is worthy of further study.

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Section: Discussionmentioning

confidence: 99%

Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis

Lin

et al. 2019

BioMed Research International

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“…Numerous findings support that oxidative stress is related to telomere shortening [25]. Oxidative stress triggers telomere attrition in endothelial cells [26] and vascular smooth muscle cells [27,28].…”

Section: Discussionmentioning

confidence: 93%

NADPH Oxidase Overactivity Underlies Telomere Shortening in Human Atherosclerosis

Pejenaute

Cortés

Marqués

et al. 2020

IJMS

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Telomere shortening and oxidative stress are involved in the pathogenesis of atherosclerosis. Different studies have shown that phagocytic NADPH oxidase is associated with this disease. This study aimed to investigate the association between phagocytic NADPH oxidase and telomere shortening in human atherosclerosis. To assess this potential association, telomere length and phagocytic NADPH oxidase activity were determined by PCR and chemiluminescence, respectively, in a population of asymptomatic subjects free of overt clinical atherosclerosis. We also measured serum 8-hydroxy-2-deoxyguanosine (8-OHdG) levels (an index of oxidative stress) and carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis. After adjusting them for age and sex, telomere length inversely correlated (p < 0.05) with NADPH oxidase-mediated superoxide production, with 8-OHdG values, and with carotid IMT. Interestingly, the asymptomatic subjects with plaques have a lower telomere length (p < 0.05), and higher values of plasma 8-OHdG and superoxide production (p < 0.05). These data were confirmed in a second population in which patients with coronary artery disease showed lower telomere length and higher 8-OHdG and superoxide production than the asymptomatic subjects. In both studies, NADPH oxidase-dependent superoxide production in phagocytic cells was only due to the specific expression of the Nox2 isoform. In conclusion, these findings suggest that phagocytic NADPH oxidase may be involved in oxidative stress-mediated telomere shortening, and that this axis may be critically involved in human atherosclerosis.

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“…People with cardiovascular diseases are also characterized by shortening of telomeres and an increased level of oxidative stress (Tian et al, 2017). These regularities seem to be less pronounced in those who practice an active lifestyle.…”

Section: Discussionmentioning

confidence: 99%

Influence of music therapy on the telomere length: a brief review and a pilot study

Spivak¹,

Смирнова²,

Urazova³

et al. 2019

biologija

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Relation between music perception and telomere length is discussed. Telomeres are now considered as markers of general health and as possible predictor of life expectancy, while their length correlates with either the risk of age-related pathologies or with higher adaptive performance. The ability to withstand agerelated telomere shortening by means of practicing psychological training is discussed. Problems and prospects of present-day music therapy are reviewed, as well as absence of studies of alteration of telomere length, related to music perception. Sixty-three practically healthy young (aged 24 ± 5 years) randomly selected Russian-speaking students were divided into three subgroups, each of which listened to music of a specific type for 14 days, 90 minutes each day. Before and after the two-week course, the telomere length and telomerase activity in blood samples were measured. A limited but statistically reliable increase in the telomere length and in telomerase activity is demonstrated to have occurred as a result of completing the music course. Classical music tends to bring about less stress, positively affect one’s mood, and physiology, and, finally, such essential aging markers as telomerase activity and the telomere length. Non-classical music conditioned manifestation of some stress, which tended to affect the telomere length in a negative way. In order to cope with this difficulty, telomerase was activated.

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Association Between Oxidative Stress and Peripheral Leukocyte Telomere Length in Patients with Premature Coronary Artery Disease

Cited by 31 publications

References 27 publications

Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis

Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis

NADPH Oxidase Overactivity Underlies Telomere Shortening in Human Atherosclerosis

Influence of music therapy on the telomere length: a brief review and a pilot study

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