Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women

Micali, Nadia; Crous‐Bou, Marta; Treasure, Janet; Lawson, Elizabeth A.

doi:10.1002/erv.2486

Cited by 36 publications

(34 citation statements)

References 46 publications

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“…Furthermore, no differences were found in basal or stimulated peripheral levels of oxytocin in women with bulimia nervosa compared with controls 65,68 . In the past 5 years, studies in women have identified associations between genetic variation in the oxytocin receptor and eating disorder diagnosis (bulimia nervosa) 70 , eating disorder thoughts and behaviours (in those with anorexia nervosa as well as a community sample of women) 71-73 , food preoccupation (in anorexia nervosa) 71 and reported nutrient intake (in a community sample of women) 72 .…”

Section: Eating Behaviourmentioning

confidence: 99%

The effects of oxytocin on eating behaviour and metabolism in humans

2017

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Section: Eating Behaviourmentioning

confidence: 99%

The effects of oxytocin on eating behaviour and metabolism in humans

2017

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“…Patients with eating disorders frequently show emotional and social dysfunctions, which induce stressful situations and exacerbate symptoms of eating disorders. Genetic predispositions of oxytocin systems have been suggested to induce vulnerability to stressful stimuli and liability to overeating or eating disorders in humans 165,[233][234][235][236]. A negative relationship between socioeconomic status and childhood obesity has been shown in A allele carriers of the oxytocin receptor gene SNP rs53576 237.…”

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confidence: 99%

Role of oxytocin in the control of stress and food intake

Onaka

Takayanagi

2019

J Neuroendocrinology

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Oxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake. The oxytocin receptor is located in various brain regions, including the sensory information‐processing cerebral cortex; the cognitive information‐processing prefrontal cortex; reward‐related regions such as the ventral tegmental areas, nucleus accumbens and raphe nucleus; stress‐related areas such as the amygdala, hippocampus, ventrolateral part of the ventromedial hypothalamus and ventrolateral periaqueductal gray; homeostasis‐controlling hypothalamus; and the dorsal motor complex controlling intestinal functions. Oxytocin affects behavioural and neuroendocrine stress responses and terminates food intake by acting on the metabolic or nutritional homeostasis system, modulating emotional processing, reducing reward values of food intake, and facilitating sensory and cognitive processing via multiple brain regions. Oxytocin also plays a role in interactive actions between stress and food intake and contributes to adaptive active coping behaviours.

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“…For example, Kim et al reported that the G allele of the rs53576 oxytocin receptor gene polymorphism is associated with greater risk for BN. Similarly, Micali et al found that the GG variant of the same gene is associated with greater binging and purging behaviour in women. Micali et al also found evidence of a gene X environment interaction, such that the AG/GA variant of the rs2254298 oxytocin receptor gene polymorphism is associated with greater binging and purging behaviour specifically in the context of poor maternal care.…”

Section: Discussionmentioning

confidence: 91%

“…Similarly, Micali et al found that the GG variant of the same gene is associated with greater binging and purging behaviour in women. Micali et al also found evidence of a gene X environment interaction, such that the AG/GA variant of the rs2254298 oxytocin receptor gene polymorphism is associated with greater binging and purging behaviour specifically in the context of poor maternal care. This pattern of findings suggests that differences in oxytocinergic functioning play a functional role in recurrent binge‐purge behaviour.…”

Section: Discussionmentioning

confidence: 91%

The influence of oxytocin on risk‐taking in the balloon analogue risk task among women with bulimia nervosa and binge eating disorder

Leslie

Leppänen

Paloyelis

et al. 2019

J Neuroendocrinology

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| INTRODUC TI ONRecurrent loss-of-control binge eating characterises the DSM-5 eating disorders bulimia nervosa (BN) and binge eating disorder (BED). 1 Binge eating behaviour is associated with significant distress, guilt and shame, 1-3 and detracts from the overall quality of life of the affected individuals. 4 Furthermore, populations with recurrent binge eating behaviour, including those with BN and BED, have been found to exhibit heightened levels of risk-taking behaviour, as indicated by the high comorbidity of BN and BED with substance abuse disorders and self-harm behaviour. 5,6 The role of impulsivity in binge eating behaviour has been well-studied, and has been proposed to account for higher levels of risk-taking behaviour in populations with recurrent binge AbstractPrevious theoretical models of bulimia nervosa (BN) and binge eating disorder (BED) have implicated cross-domain risk-taking behaviour as a significant maintenance factor in both disorders. The present study aimed to test this hypothesis by administering the Balloon Analogue Risk Task (BART) to 25 women with BN or BED and 27 healthy comparison women without a history of an eating disorder. Furthermore, we tested the effect of a divided dose of 64 IU of oxytocin on risk-taking behaviour in the BART. Contrary to our hypothesis, women with BN or BED did not exhibit baseline differences in performance on the BART in the placebo condition (t = 1.42, df = 50, P = 0.161, d = 0.39). Oxytocin did not have a main effect on performance in the BART (F = 0.01, df = 1, P = .907, η 2 partial < 0.001); however, there was an interaction, such that participants in the BN/BED participant group, compared to the healthy comparison group, demonstrated safer behaviour on the BART in the oxytocin condition, but not in the placebo condition (F = 4.29, df = 1, P = 0.044, η 2 partial = 0.082). These findings cast doubt on the common assumption that individuals with BN and BED exhibit greater risk-taking behaviour in all domains and add to the evidence that oxytocin plays a functional role in modulating behaviours that entail trade-offs between reward approach and risk in humans. We recommend that future dose-response studies investigate the effect of oxytocin on reward approach behaviour further in women with recurrent binge eating behaviour, as well as the clinical significance of this effect. K E Y W O R D Sbinge eating disorder, bulimia nervosa, oxytocin, risk-taking

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Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women

Cited by 36 publications

References 46 publications

The effects of oxytocin on eating behaviour and metabolism in humans

The effects of oxytocin on eating behaviour and metabolism in humans

Role of oxytocin in the control of stress and food intake

The influence of oxytocin on risk‐taking in the balloon analogue risk task among women with bulimia nervosa and binge eating disorder

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