Association between p53 Arg72Pro polymorphism and recurrent pregnancy loss: an updated systematic review and meta-analysis

Abstract

The p53 tumour suppressor gene plays an important role in angiogenesis and apoptosis. The association between Arg72Pro polymorphism and recurrent pregnancy loss (RPL) has been studied but with inconsistent results. A meta-analysis was conducted to examine whether p53 Arg72Pro polymorphism is a risk factor for RPL. Electronic searches of PubMed, Embase and Web of Knowledge were conducted to identify relevant studies. The final meta-analysis included six published articles with 730 RPL cases and 613 controls. The pooled results suggested that the variant genotype was associated with the RPL risk in additive model (Pro versus Arg; odds ratio [OR] = 1.28; 95% confidence interval [CI]: 1.06 to 1.54) and recessive model (Pro/Pro versus Arg/Pro + Arg/Arg; OR = 1.82; 95% CI: 1.21 to 2.73). In the stratified analysis by ethnicity, for white people the results were consistent. The Egger's regression asymmetry test suggested a lack of publication bias. Results of this meta-analysis suggest that p53 codon 72 polymorphism is associated with RPL, especially in white people. Identification of p53 codon 72 mutation would have some implication for primary prevention of RPL and screening of high-risk individuals. Large well-designed studies are needed to fully describe the association between this polymorphism and RPL.

Role of <i>P53</i> p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome

“…These results are consistent with five meta-analyses examining the relationship between p53 p.Arg72Pro variant and RPL [11,[36][37][38][39]. Tang et al, 2011 analyzed four case control studies and concluded that women with the homozygous Pro/Pro genotype had an increased risk of RPL [11].…”

Impact of CAG repeat length in the androgen receptor gene on male infertility – a meta-analysis

“…Heterogeneity was judged by calculating the I 2 statistic, where an I 2 value from 0 to 25% indicates low heterogeneity, 25-50% moderate heterogeneity and ≥50% high heterogeneity . For I 2 < 50%, a fixed effect model was chosen, and for I 2 ≥ 50%, a random effect model was chosen (Chen et al, 2015). All statistical analyses were undertaken using STATA version 12.0.…”

Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion

“…However, limited data made it necessary for us to be cautious in these studies. Chen et al [22] conducted another meta-analysis including 6 studies in 2015. There existed a significant association in allelic model (Pro vs. Arg) and recessive model (Pro/Pro vs. Arg/Pro+Arg/Arg), and subgroup analysis by ethnicity also indicated a significant association in Caucasian group.…”