Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion

Abstract

p53 gene plays an important role in apoptosis, which is necessary for successful invasion of trophoblast cells. The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA). In order to investigate the association between p53 polymorphism at codon 72 and RSA, we conducted this meta-analysis. Pubmed, Embase and Web of science were used to identify the eligible studies. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of the association. Six studies containing 937 cases of RSA and 830 controls were included, and there was one study deviated from Hardy-Weinberg equilibrium (HWE). There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not. A significant association was observed in allelic model (Pro vs. Arg; OR=1.28, 95% CI: 1.04-1.57) after exclusion of the study that was deviated from HWE. No association was noted in recessive model (Pro/Pro+Pro/Arg vs. Arg/Arg; OR=1.05, 95% CI: 0.86-1.30) and co-dominant model (Pro/Arg vs. Arg/Arg; OR=0.96, 95% CI: 0.77-1.19). Subgroup analysis by ethnicity also indicated a significant association between p53 polymorphism at codon 72 and RSA in Caucasian group. No heterogeneity and publication bias were found. Our meta-analysis implied that p53 polymorphism at codon 72 carries high maternal risk of RSA.

Role of <i>P53</i> p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome

“…These results are consistent with five meta-analyses examining the relationship between p53 p.Arg72Pro variant and RPL [11,[36][37][38][39]. Tang et al, 2011 analyzed four case control studies and concluded that women with the homozygous Pro/Pro genotype had an increased risk of RPL [11].…”

The ‑2549 insertion/deletion polymorphism in the promoter region of VEGF is associated with the risk of recurrent spontaneous abortion

“…A number of studies have demonstrated an association between genetic variants and the risk of RSA (27)(28)(29)(30). VEGF is among the established regulators of angiogenesis during pregnancy and has been associated with RSA (31,32).…”

Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population

“…19,20 Furthermore, studies have found that some genes that regulate cell proliferation, invasion, and migration are associated with susceptibility to miscarriage; for example, H19 and p53 gene polymorphisms. 8,21 These studies suggest that TINCR gene polymorphisms may be associated with recurrent miscarriage. However, there have been no previous studies on the association between TINCR polymorphism rs2288947 A > G and recurrent miscarriage; therefore, we conducted this study.…”

“…Recently, studies have found that genetic variation in TINCR was associated with a variety of diseases, such as the SNP rs2288947, which contributed to the susceptibility and progression of colorectal cancer and susceptibility to gastric cancer . Furthermore, studies have found that some genes that regulate cell proliferation, invasion, and migration are associated with susceptibility to miscarriage; for example, H19 and p53 gene polymorphisms . These studies suggest that TINCR gene polymorphisms may be associated with recurrent miscarriage.…”

“…In recent years, with the increase in research on recurrent abortion, an increasing number of susceptibility genes, such as MMP2, MMP9, CTLA4, FOXP3, and THBD, have been found to be associated with susceptibility to recurrent miscarriage . In addition, studies have confirmed that some genes that regulate cell migration are associated with susceptibility to recurrent miscarriage Studies have also found that long non‐coding RNA (lncRNA) polymorphisms are also associated with recurrent miscarriage. For example, in the early stage, we studied MALAT1, which regulates cell migration and is associated with susceptibility to recurrent miscarriage.…”