Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis

Zhou, Xin; Gu, Yang; Zhang, Shulan

doi:10.7314/apjcp.2012.13.10.4909

Cited by 43 publications

(37 citation statements)

References 39 publications

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“…Disruption of tumor suppressor protein p53 is a common event in cervical cancer and cervical cancer cases (Zhou et al, 2012). Overexpression of HDAC1 and E6 oncoprotein was reported to associate with destabilization and degradation of p53 (Luczak et al, 2008;Mizuguchi et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Reversal of Resistance towards Cisplatin by Curcumin in Cervical Cancer Cells

Roy¹,

Mukherjee²

2014

Asian Pacific Journal of Cancer Prevention

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Epigenetic regulators like histone deacetylases (1 and 2), and viral onco-proteins (E6/E7) are known to be overexpressed in cervical cancer cells. The present study was designed to investigate the effect of curcumin on HDACs (1 and 2) and HPV E6/E7 in the cervical cancer cell line SiHa and a drug resistant clone SiHa R (derived from SiHa). It was further intended to investigate whether curcumin could sensitize the cells towards cisplatin induced cell killing by modulation of multi drug resistant proteins like MRP1 and Pgp1. Curcumin inhibited HDACs, HPV expression and differentially increased acetylation and up-regulation of p53 in SiHa and SiHa R , leading to cell cycle arrest at G1-S phase. Up-regulation of pRb, p21, p27 and corresponding inhibition of cyclin D1 and CDK4 were observed. Cisplatin resistance in SiHa R due to over-expression of MRP1 and Pgp1 was overcome by curcumin. Curcumin also sensitized both the cervical cancer cells towards cisplatin induced cell killing. Inhibition of HDACs and HPVs led to cell cycle arrest at G1/S phase by alteration of cell cycle regulatory proteins. Suppression of MRP1 and Pgp1 by curcumin resulted in sensitization of cervical cancer cells, lowering the chemotherapeutic dose of the drug cisplatin.

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Section: Discussionmentioning

confidence: 99%

Reversal of Resistance towards Cisplatin by Curcumin in Cervical Cancer Cells

Roy¹,

Mukherjee²

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…A meta-analysis of eight studies suggested that the genetic polymorphism in IL-10-592C/A was a risk factor for developing cervical cancer, especially for Asians (Ni et al, 2013). A meta-analysis of twentyeight case-control studies suggested that p53 codon 72 polymorphisms might be associated with increased risk of cervical cancer, especially among Indians (Zhou et al, 2012). A meta-analysis of 21 case-control studies provided strong evidence that the GSTM1 genotype was associated with the development of cervical cancer, especially in smokers, and Chinese and Indian populations (Zhang et al, 2012a).…”

Section: Discussionmentioning

confidence: 99%

Stratification Analysis and Case-control Study of Relationships between Interleukin-6 Gene Polymorphisms and Cervical Cancer Risk in a Chinese Population

Shi¹,

Líu²,

Wu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…This process is regulated by cyclins and cyclin-dependent kinases. Disruption of tumor suppressor protein p53 is a common event in cervical cancer (Zhou et al, 2012). 8-60hIPP5m stimulates cellular responses through the activation of ATM/p53/p21 cip1/waf1 signal pathways.…”

Section: Discussionmentioning

confidence: 99%

8-60hIPP5^m-Induced G2/M Cell Cycle Arrest Involves Activation of ATM/p53/p21^cip1/waf1Pathways and Delayed Cyclin B1 Nuclear Translocation

Zeng

Zeng²,

Huang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Protein phosphatase 1 (PP1) is a major serine/threonine phosphatase that controls gene expression and cell cycle progression. The active mutant IPP5 (8-60hIPP5 m ), the latest member of the inhibitory molecules for PP1, has been shown to inhibit the growth of human cervix carcinoma cells (HeLa). In order to elucidate the underlying mechanisms, the present study assessed overexpression of 8-60hIPP5 m in HeLa cells. Flow cytometric and biochemical analyses showed that overexpression of 8-60hIPP5 m induced G2/M-phase arrest, which was accompanied by the upregulation of cyclin B1 and phosphorylation of G2/M-phase proteins ATM, p53, p21 cip1/waf1 and Cdc2, suggesting that 8-60hIPP5 m induces G2/M arrest through activation of the ATM/p53/p21 cip1/waf1 /Cdc2/ cyclin B1 pathways. We further showed that overexpression of 8-60hIPP5m led to delayed nuclear translocation of cyclin B1. 8-60hIPP5 m also could translocate to the nucleus in G2/M phase and interact with pp1α and Cdc2 as demonstrated by co-precipitation assay. Taken together, our data demonstrate a novel role for 8-60hIPP5m in regulation of cell cycle in HeLa cells, possibly contributing to the development of new therapeutic strategies for cervix carcinoma.

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Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis

Cited by 43 publications

References 39 publications

Reversal of Resistance towards Cisplatin by Curcumin in Cervical Cancer Cells

Reversal of Resistance towards Cisplatin by Curcumin in Cervical Cancer Cells

Stratification Analysis and Case-control Study of Relationships between Interleukin-6 Gene Polymorphisms and Cervical Cancer Risk in a Chinese Population

8-60hIPP5^m-Induced G2/M Cell Cycle Arrest Involves Activation of ATM/p53/p21^cip1/waf1Pathways and Delayed Cyclin B1 Nuclear Translocation

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Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis

Cited by 43 publications

References 39 publications

Reversal of Resistance towards Cisplatin by Curcumin in Cervical Cancer Cells

Reversal of Resistance towards Cisplatin by Curcumin in Cervical Cancer Cells

Stratification Analysis and Case-control Study of Relationships between Interleukin-6 Gene Polymorphisms and Cervical Cancer Risk in a Chinese Population

8-60hIPP5m-Induced G2/M Cell Cycle Arrest Involves Activation of ATM/p53/p21cip1/waf1Pathways and Delayed Cyclin B1 Nuclear Translocation

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8-60hIPP5^m-Induced G2/M Cell Cycle Arrest Involves Activation of ATM/p53/p21^cip1/waf1Pathways and Delayed Cyclin B1 Nuclear Translocation