Association between Perfluoroalkyl substances and thyroid stimulating hormone among pregnant women: a cross-sectional study

Wang, Yan; Starling, Anne P.; Haug, Line Småstuen; Eggesbø, Merete; Becher, Georg; Thomsen, Cathrine; Travlos, Gregory S.; King, Debra; Hoppin, Jane A.; Rogan, Walter J.; Longnecker, Matthew P.

doi:10.1186/1476-069x-12-76

Cited by 58 publications

(60 citation statements)

References 48 publications

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“…Another potential mechanism by which PFASs might have an adverse effect on neurodevelopment is through interference with thyroid hormone signaling. The thyroid hormone plays a role in synaptogenesis and myelination in the developing brain during the prenatal and postnatal periods, and previous studies in human reported associations between exposure to PFASs and thyroid gland disruption (Melzer et al 2010; Wang et al 2014; Wang et al 2013). …”

Section: Discussionmentioning

confidence: 96%

Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances

Oulhote

Steuerwald

Debes

et al. 2016

Environment International

107

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Background Perfluorinated alkyl substances (PFAS) are suspected endocrine disruptors that are highly persistent and neurotoxic in animals. Human epidemiological studies of exposure-related deviations of children’s behaviors are sparse. We assessed the associations between prenatal, 5- and 7-year PFAS exposures and behavioral problem scores in 7-year Faroese children. Methods Concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA), perfluorooctane sulfonate (PFOS), and perfluorohexane sulfonic acid (PFHxS) were measured in maternal serum and in serum from children at ages 5 and 7 years (n=539, 508, and 491, respectively). We used multivariable regressions and structural equations models to estimate the covariate-adjusted associations between serum-PFAS concentrations and behavioral difficulties, as assessed by the strengths and difficulties questionnaire (SDQ) at age 7. Results Serum-PFOS and PFHxS concentrations declined over time, whereas PFOA, PFNA, and PFDA tended to increase. No associations were observed between prenatal PFAS concentrations and SDQ scores. However, a two-fold increase in 5-year serum-PFOA, PFNA, and PFDA concentrations was associated with increases in total SDQ scores by 1.03 (95% CI: 0.11, 1.95), 0.72 (95% CI: 0.07, 1.38) and 0.78 points (95% CI: 0.01, 1.55), respectively. For SDQ subscales, significant associations were found in regard to hyperactivity, peer relationship, and conduct problems, as well as internalizing and externalizing problems and autism screening composite scores. Cross-sectional analyses at age 7 years showed possible sex-dimorphic associations between PFAS concentrations and SDQ scores, where girls had consistently positive associations with SDQ scores whereas boys exhibited a pattern of negative or null associations. Conclusions Higher serum PFAS concentrations at ages 5- and 7-years, but not prenatally, were associated with parent-reported behavioral problems at age 7.

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Section: Discussionmentioning

confidence: 96%

Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances

Oulhote

Steuerwald

Debes

et al. 2016

Environment International

107

View full text Add to dashboard Cite

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“…In vitro models suggested that PFASs can directly influence neuronal differentiation [101]. PFASs can compete with T4 for binding to transthyretin, a main carrier protein of TH in mammals [102], thus increasing thyroid-stimulating hormone (TSH) and decreasing free thyroxine (fT4) [103–105]. Thyroid hormones transferred from the mother to the embryo and fetuses are critical for normal brain development [106], and TH deficiency during gestation may cause cognitive and/or mental disorders [107–111].…”

Section: Discussionmentioning

confidence: 99%

Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes

Liew

Goudarzi

Oulhote

2018

Curr Envir Health Rpt

182

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PFASs are persistent organic pollutants that have been widely produced and used in a range of commercial products since the 1950s. Human exposures to PFASs are nearly ubiquitous globally, but studies that addressed potential health effects of PFASs have only begun to accumulate in recent years. Animal studies suggest adverse effects resulting from developmental encompasses prenatal exposures to PFASs. In humans, the developing fetus is exposed to PFASs via active or passive placenta transfer, while newborns might be exposed via breastfeeding or PFAS in the home environment. Overall, epidemiological findings are consistent and suggest possible associations with fetal and postnatal growth and immune function, while the findings on neurodevelopmental endpoints to date are rather inconclusive. Methodological challenges and future directions for PFASs-focused research are discussed.

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“…When assessing individual contaminants, we demonstrated significant associations between PFOS and TSH. Accordingly, PFOS was positively associated with TSH in pregnant women in Norway sampled in 1999–2008 (Wang et al 2013). Further, we demonstrated that PCBs, HCB, and nonachlors were inversely associated with T 3 , T 4 , and FT 4 .…”

Section: Discussionmentioning

confidence: 99%

Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment

Berg

Nøst

Pettersen

et al. 2017

Environ Health Perspect

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Background:Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis.Objectives:We investigated the association between POPs and thyroid-stimulating hormone (TSH) and thyroid hormones (THs) in mother and child pairs from the Northern Norway Mother-and-Child Contaminant Cohort Study (MISA).Methods:Nineteen POPs and 10 thyroid parameters were analyzed in serum from 391 pregnant women in their second trimester. In addition, TSH concentrations in heel-prick samples from the infants were analyzed by the Norwegian Newborn Screening program. Association studies with a multipollutant approach were performed using multivariate analyses; partial least squares (PLS) regression, hierarchical clustering, and principal component analysis (PCA).Results:Several POPs were significantly associated with TSH and THs: a) PFOS was positively associated with TSH; b) PCBs, HCB, and nonachlors were inversely associated with T3, T4, and FT4; and, c) PFDA and PFUnDA were inversely associated with T3 and FT3. After mutual adjustments for the other contaminants, only PFDA and PFUnDA remained significantly associated with T3 and FT3, respectively. Infants born to mothers within the highest TSH quartile had 10% higher mean concentrations of TSH compared with children born to mothers in the lowest TSH quartile.Conclusion:The present results suggest that background exposures to POPs can alter maternal thyroid homeostasis. This research contributes to the understanding of multipollutant exposures using multivariate statistical approaches and highlights the complexity of investigating environmental concentrations and mixtures in regard to maternal and infant thyroid function.Citation:Berg V, Nøst TH, Pettersen RD, Hansen S, Veyhe AS, Jorde R, Odland JØ, Sandanger TM. 2017. Persistent organic pollutants and the association with maternal and infant thyroid homeostasis: a multipollutant assessment. Environ Health Perspect 125:127–133; http://dx.doi.org/10.1289/EHP152

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Association between Perfluoroalkyl substances and thyroid stimulating hormone among pregnant women: a cross-sectional study

Cited by 58 publications

References 48 publications

Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances

Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances

Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes

Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment

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