Association between periodontitis and spontaneous abortion: A case‐control study

Abstract

Background Spontaneous abortion, or miscarriage, is a complication of pregnancy which can severely affect women both physically and psychologically. We investigated the associations of periodontitis and periodontopathic bacteria with spontaneous abortion. Methods We conducted a matched case‐control study in two tertiary hospitals in Khon Kaen, Thailand. Cases were 85 women with spontaneous abortion at <20 weeks of gestation matched to 85 controls on age, gestational age, and hospital. Full‐mouth periodontal examinations were performed. Periodontitis was defined as at least one site with probing depth ≥5 mm and clinical attachment level ≥2 mm at the same site. Subgingival plaque samples were collected to determine the levels of Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum using real time polymerase chain reaction. Results The cases were significantly more likely to have periodontitis (50.6%) than the controls (21.2%; P = 0.007). Conditional logistic regression revealed a crude odds ratio (OR) of 4.1 for the association between periodontitis and spontaneous abortion (95% confidence interval [CI] = 1.9–8.9, P = 0.001). The OR decreased, but was still significant, after controlling for previous miscarriage (OR = 3.3, 95% CI = 1.4–7.8, P = 0.006). There was no significant association between the levels of periodontopathic bacteria and spontaneous abortion. Increased levels of P. gingivalis and F. nucleatum were associated with periodontitis in both case and control groups. Association between increased T. forsythia levels and periodontitis was observed only in the case women. Conclusions Periodontitis was more common in women with spontaneous abortions as compared with matched controls. Levels of periodontopathic bacteria was not associated with spontaneous abortion in this population.

Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study

“…Chanomethaporn on the other hand, suggests the association between PD and spontaneous abortion. These associations, however, were not found in this study [22].…”

Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity

“…Fusobacterium nucleatum ( F. nucleatum ) is a Gram-negative, anaerobic oral commensal bacterium that is associated with a variety of human diseases, including periodontal disease [20], Alzheimer's disease [21], brain abscess [22], cardiovascular disease [23], miscarriage [24] and inflammatory bowel disease [25]. Recently, F. nucleatum has been proposed to be associated with CRC [26].…”

The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review

“…They showed an overall increase in pathogenic bacteria such as Clostridium perfringens and Bulleidia moorei and a reduction in probiotic bacteria Coprococcus catus. A correlation between periodontitis and the risk of spontaneous abortion or miscarriage has also been described [96]. More well-controlled studies should be carried out in order to identify interactions between pregnancy microbiome and mother and children health which might help to predict gestational and newborn complications and search for new therapeutic targets in adverse obstetrical conditions.…”