Association between polymorphisms in microRNAs and ischemic stroke in an Asian population: evidence based on 6,083 cases and 7,248 controls

Abstract

BackgroundPolymorphisms in miR-146a (rs2910164), miR-196a2 (rs11614913), miR-149 (rs2292832) and miR-499 (rs3746444) have been associated with ischemic stroke (IS), but studies have given inconsistent results.MethodsThis meta-analysis investigated the possible association between IS risk and the four polymorphisms. A total of 14 case-control studies from Asian populations involving 6,083 cases and 7,248 controls for the four polymorphisms were included.ResultsResults showed that the GG genotype of miR-146a (rs2910164) may be associated with increased IS risk according to the recessive model (OR=1.20, 95% CI=1.02–1.42, P=0.03). Similarly, the CC genotype of miR-149 (rs2292832) may be associated with increased IS risk according to the recessive model (OR=1.28, 95% CI=1.08–1.52, P=0.005) and the homozygous model (OR=1.31, 95% CI=1.09–1.58, P=0.004). In contrast, miR-196a2 (rs11614913) and miR-499 (rs3746444) polymorphisms did not show significant association with IS risk in any of the five genetic models.ConclusionThese results indicate that the GG genotype of miR-146a (rs2910164) and CC genotype of miR-149 (rs2292832) may confer increased susceptibility to IS, while miR-196a2 (rs11614913) and miR-499 (rs3746444) polymorphisms may not be associated with IS risk in Asian populations. These conclusions should be verified in large and well-designed studies.

Association between miR‑499 rs3746444 polymorphism and the risk of ischemic stroke: A systematic review and meta‑analysis

“…In a previous review article, Zou et al (21) concluded that the miR-499 (rs3746444) polymorphism may not be associated with a risk of IS in Asian populations. However, in the present study, neither the allelic model, dominant model, recessive model, homozygote model, or the heterozygote model were found to be significant in the study by Zou et al However, as 3 Chinese articles were included in the review article by Zou et al (21), it is difficult for researchers who do not speak Chinese to repeat the results.…”

MiR-10a, 27a, 34b/c, and 300 Polymorphisms are Associated with Ischemic Stroke Susceptibility and Post-Stroke Mortality

“…The direct regulatory effects and predicted targeting effects against ACE and PAI-1, mediated by miR-10a, miR-27a, miR-34b/c, and miR-300, have been described by previous studies [43][44][45][46]66]. Moreover, we have already reported the association between another miRNA and ischemic stroke, and many studies in another population demonstrated the association between other miRNAs and ischemic stroke [78][79][80][81].…”

3-<em>n</em>-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke

“…Ischemic stroke is thought to occur when cerebral artery stenosis and reduction or interruption of regional cerebral blood flow decrease the supply of oxygen and energy to brain tissue, triggering secondary vascular endothelial damage and autonomic nervous dysfunction. 4,5 Cellular and animal models and postmortem studies indicate that ischemic stroke involves oxidative stress, apoptosis, calcium overload, mitochondrial dysfunction, inflammatory and immune responses, as well as changes in microRNA levels. [6][7][8][9] Mitochondrial dysfunction appears to contribute to ischemic stroke by increasing oxidative stress, perturbing calcium homeostasis and inducing neuronal apoptosis.…”