2021
DOI: 10.5501/wjv.v10.i3.111
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Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach

Abstract: BACKGROUND Vitamin D population status may have possible unappreciated consequences to the coronavirus disease 2019 (COVID-19) pandemic. Α significant association between vitamin D sufficiency and reduction in clinical severity and inpatient mortality from COVID-19 disease has recently been shown, while a recent study has claimed lower COVID-19 cases in European countries with a better vitamin D status. Low serum 25-hydroxyvitamin-D [25(OH)D] was identified as an independent risk factor for COVID-… Show more

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Cited by 14 publications
(30 citation statements)
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“…Moreover, the decision of the Finish authorities to fortify dietary milk products with vitamin D had led to a decrease in the number of T1DM cases [16]. From another point of view, the capacity of vitamin D to enhance the immune system might ensure a protective effect from developing severe forms of SARS-CoV-2 infection and reduce the risk of contracting the disease [17].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the decision of the Finish authorities to fortify dietary milk products with vitamin D had led to a decrease in the number of T1DM cases [16]. From another point of view, the capacity of vitamin D to enhance the immune system might ensure a protective effect from developing severe forms of SARS-CoV-2 infection and reduce the risk of contracting the disease [17].…”
Section: Introductionmentioning
confidence: 99%
“… 6 7 A geographical association between vitamin D deficiency prevalence and COVID-19 incidence and mortality has been reported. 8 Free 25(OH)D has not yet been investigated in COVID-19, but this is required to fully understand vitamin D status during acute illness and any associations with systemic inflammation. 9 Clinical trials of vitamin D supplementation in respiratory diseases have returned mixed results.…”
Section: Introductionmentioning
confidence: 99%
“…We read with great interest the article entitled “Association between population vitamin D status and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) related serious-critical illness and deaths: An ecological integrative approach” recently published by Papadimitriou et al [ 1 ] in the World Journal of Virology [ 1 ]. This manuscript raised important questions and the authors performed an extensive analysis on vitamin D levels and COVID-19 incidence and severity in Europe, and the potential benefits of vitamin D supplementation to enhance the immune response to the SARS-CoV-2[ 1 ]. In the light of these results, we humbly want to state a few points for consideration.…”
Section: To the Editormentioning
confidence: 99%
“…Vitamin D deficiency is associated with poor response to respiratory infections[ 10 ], and few reports have identified vitamin D deficiency in moderate and severe COVID-19 patients with conflicting results[ 1 , 11 , 12 ].…”
Section: To the Editormentioning
confidence: 99%
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