Association between prolactin receptor gene polymorphism (PRLR) with reproduction performance traits of Polish swine

Terman, A.; Polasik, Daniel; Korpal, Agnieszka; Woźniak, Katarzyna; Prüffer, K.; Żak, G.; Lambert, B.D.

doi:10.1139/cjas-2016-0096

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…However, later studies in various crossbreds and pure breeds have not always confirmed these results. Even though the same trend was obtained in most cases, a statistically significant difference was not always observed [ 7 , 8 ] or it was restricted to some parities [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 55%

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Marantidis

Laliotis

Avdi

2016

Genetics Research International

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PCR-RFLP was applied to a commercial crossbred pig population in order to investigate the association between polymorphism (SNP) of Retinol-binding protein 4 (RBP4) gene and reproductive performance. 400 sows were genotyped and 2000 records of reproductive traits were used in order to retrieve information about the allele frequencies and the association of the RBP4 gene with main reproductive characteristics of the population. A deviation from the Hardy-Weinberg equilibrium was observed as a result of the AB genotype excess. In addition, the AA genotype saw statistically significant higher values of (i) the total number of born piglets (p < 0.05), (ii) the number of piglets born alive (p < 0.01), and (iii) the number of weaned piglets (p < 0.01). The number of the mummified piglets and the number of the piglets born dead did not differ between the various RBP4 genotypes. Interestingly, the AA genotype had a negative impact (p < 0.05) on the number of piglets born dead, resulting indirectly in a larger litter size. In conclusion, the AA genotype and in extension the A allele of RBP4 gene are in favor of producing larger litter size, suggesting that the RBP4 gene may be used in Marker-Assisted Selection (MAS) programs for a rapid improvement of the reproductive characteristics in pigs.

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Section: Introductionmentioning

confidence: 55%

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Marantidis

Laliotis

Avdi

2016

Genetics Research International

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“…The changes in target gene expression in endometrium further explain the mechanism underlying the different fetal survival rate during early gestation of LW and MS gilts. The RBP4 gene is a strong candidate to litter size in pigs by supplying vitamin A to the developing fetus ( Terman et al, 2011 ). Retinol would improve the uniformity of fetal size and the synchronism of development ( Bao et al, 2012 ) therefore improving the fetal survival rate.…”

Section: Discussionmentioning

confidence: 99%

Dietary energy intake affects fetal survival and development during early and middle pregnancy in Large White and Meishan gilts

Che

Yang

et al. 2015

Animal Nutrition

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This experiment was designed to determine the effects of variations in dietary energy intake on reproductive performance and gene expression of luteal and endometrium tissues in Large White (LW) and Meishan (MS) gilts during early and middle pregnancy. After insemination, 32 LW gilts were assigned to high and low (HEL and LEL, 14.23 and 12.56 MJ DE/kg, respectively) diet treatment groups, while 32 MS gilts were allocated to HEM and LEM (12.56 and 10.88 MJ DE/kg) groups. Gilts were slaughtered on days 35, 55 and 90 of gestation. The fetal survival and luteal progesterone (P4) concentration in the HEL group were higher on day 35 but lower on day 90 of gestation compared with the LEL group (P < 0.05) for LW gilts. However, fetal survival and luteal P4 concentration on day 35 of gestation were greater (P < 0.05) in the LEM group than in the HEM group for MS gilts, but no significant difference in mid-gestation was showed. The fetal weights of both breeds were higher for the high energy diets compared with the respective control group on day 90 of gestation (P < 0.05). In addition, the mRNA levels of P4 synthesis-related proteins had correlated with luteal P4 concentration in both breeds. Further, endometrial levels of uteroferrin (ACP5), retinol-binding protein 4 (RBP4) and secreted phosphoprotein 1 (SPP1) mRNA were upregulated in the HEL group on day 35 of gestation but ACP5 and SPP1 were downregulated on day 55 of gestation compared with the LEL group (P < 0.05) for LW gilts. In MS gilts, diet only affected the expression of SPP1 (P < 0.05). Our results revealed the differential sensitivity of LW and MS breeds to variations in dietary energy intake. For LW gilts, the HEL group improved fetal survival on day 35 but a sustained high energy diet decreased fetal survival on day 90 of gestation. The differences in dietary energy intake did not influence fetal survival on day 90 of gestation but the higher energy diet did increase fetal weight in the MS breed compared with the lower energy intake diet. These results may be due to differential luteal secretion activity and endometrium gene expression in these two breeds.

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“…In their studies, Szyndler-Nędza et al (13) as well as Szyndler-Nędza et al (12) reported similar correlations and, in addition, determined a significant variability of reproduction indicators where AA homozygotes (locus MC4R) were characterised by a higher mean number of piglets born and reared up to day 21 of life in comparison with the remaining genotype sow groups. Terman et al (14) reported a strong polymorphic association in the MC4R locus with the total number of born piglets, number of piglets born alive (P ≤ 0.05, for litters 1 and 2) and the number of piglets reared up to day 21 (P ≤ 0.01, for litter 1) between sow genotype groups, with homozygotes recording higher results.…”

Section: Resultsmentioning

confidence: 98%

Sexual activity of different gilt genotype groups of the Pulawska breed during oestrus

Babicz

Pastwa

Skrzypczak

et al. 2019

Medycyna Weterynaryjna

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The aim of the study was to analyze sexual activities of gilts representing various genotype groups in the RBP4 and MC4R locus. Observations of gilt behaviour during the first and the second oestrus (before initiation of the reproduction phase) were carried out in the Pulawska breed from conservation breeding. The evaluation process comprised the duration of the heat as well as the intensity of heat behaviours. Polymorphism identification in RBP4 (SNP: rs55618789) and MC4R (SNP: rs81219178) genes was performed, which resulted in the identification of three (MC4R: AA, AG and GG) and two (RBP4: CC and CT) gilt genotype groups. Significantly varying sexual activities were observed: the most intensive heat symptoms were demonstrated by CT gilts in the course of the first (P ≤ 0.05) and second (P ≤ 0.01) oestrus (locus RBP4) reaching, on average, 2.15 ± 0.13 and 2.52 ± 0.13 pt. It was further determined that the heats of CT gilts lasted longer and this difference, in the second heat, was significant (P ≤ 0.01). In the case of the MC4R locus, significant differences in gilt sexual activities were observed only in the course of the second oestrus (P ≤ 0.05). In addition, a strong association was also demonstrated of AA (locus MC4R) and CC (locus RBP4) genotypes with the thickness of the subcutaneous fat tissue (P ≤ 0.05) amounting in these gilts to 11.57 ± 0.21 mm and 11.50 ± 0.19 mm, respectively.

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Association between prolactin receptor gene polymorphism (PRLR) with reproduction performance traits of Polish swine

Cited by 9 publications

References 11 publications

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Association of RBP4 Genotype with Phenotypic Reproductive Traits of Sows

Dietary energy intake affects fetal survival and development during early and middle pregnancy in Large White and Meishan gilts

Sexual activity of different gilt genotype groups of the Pulawska breed during oestrus

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