Association Between Proxy- or Self-Reported Cognitive Decline and Cognitive Performance in Memory Clinic Visitors

Gruters, Angélique A A; Ramakers, Inez H.G.B.; Verhey, Frans R.J.; Köhler, Sebastian; Kessels, Roy P. C.; Vugt, Marjolein E. de

doi:10.3233/jad-180857

Cited by 20 publications

(9 citation statements)

References 58 publications

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“…This study may contribute to a better understanding of this association. Indeed, informant reports of worse cognition is related to incident dementia (Gruters et al, 2019). It is possible that the detection of cognitive decline by a knowledgeable informant may be an intermediate phase in the conversion to cognitive impairment and dementia.…”

Section: Discussionmentioning

confidence: 99%

Subjective age and informant-rated cognition and function: A prospective study.

Stéphan

Sutin²,

Luchetti³

et al. 2021

Psychology and Aging

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The present study examined whether subjective age is related to informant-rated cognition. Participants were adults (N ϭ 2,337, mean age ϭ 69.84 years, SD ϭ 7.45) from the Health and Retirement Study who provided subjective age and demographic factors in 2008/2010 and informant-rated cognition in 2016 as part of the Harmonized Cognitive Assessment Protocol. An older subjective age was associated with informant reports of steeper cognitive decline, worse cognitive function, lower ability, and loss of ability to do everyday activities. The present study indicates that subjective age predicts cognitive function in everyday life as observed by knowledgeable informants.

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Section: Discussionmentioning

confidence: 99%

Subjective age and informant-rated cognition and function: A prospective study.

Stéphan

Sutin²,

Luchetti³

et al. 2021

Psychology and Aging

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“…This lack of correlation between objective cognitive performance and subjective cognitive complaints is not specific for Lyme, but has been demonstrated in other disorders as well (including HIV, dementia, and rheumatoid arthritis) [28–30]. Subjective cognitive complaints are often associated with depressive symptoms [29]. The percentage of 2.9% cognitively impaired patients is comparable to what is found in the normal population (i.e., by definition 2.3% of a normative sample performs worse than 2 SD below the normative mean).…”

Section: Discussionmentioning

confidence: 99%

Cognitive impairments in patients with persistent symptoms attributed to Lyme disease

et al. 2019

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Background Persistent symptoms attributed to Lyme borreliosis often include self-reported cognitive impairment. However, it remains unclear whether these symptoms can be substantiated by objective cognitive testing. Methods For this observational study, cognitive performance was assessed in 280 adults with persistent symptoms attributed to Lyme borreliosis (as part of baseline data collected for the Dutch PLEASE study). Cognitive testing covered the five major domains: episodic memory, working memory / attention, verbal fluency, information-processing speed and executive function. Patients’ profiles of test scores were compared to a large age-, education- and sex-adjusted normative sample using multivariate normative comparison. Performance validity was assessed to detect suboptimal effort, and questionnaires were administered to measure self-reported cognitive complaints, fatigue, anxiety, depressive symptoms and several other psychological factors. Results Of 280 patients, one was excluded as the test battery could not be completed. Of the remaining 279 patients, 239 (85.4%) displayed sufficient performance validity. Patients with insufficient performance validity felt significantly more helpless and physically fatigued, and less orientated. Furthermore, they had a lower education level and less often paid work. Of the total study cohort 5.7% (n = 16) performed in the impaired range. Among the 239 patients who displayed sufficient performance validity, 2.9% (n = 7) were classified as cognitively impaired. No association between subjective cognitive symptoms and objective impairment was found. Conclusions Only a small percentage of patients with borreliosis-attributed persistent symptoms have objective cognitive impairment. Performance validity should be taken into account in neuropsychological examinations of these patients. Self-report questionnaires are insufficiently valid to diagnose cognitive impairment. Trial registration ClinicalTrials.gov NCT01207739. Registered 23 September 2010.

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“…As such, informants play a critical role in diagnosis and have been found to help distinguish between preclinical AD and normal aging [11]. In fact, several studies have found that informantrated cognition is a better predictor of cognitive impairment outcomes than self-reported cognition [12][13][14]. Rabin and colleagues, for example, found that informant reports provided incremental predictive power beyond episodic memory for risk of AD, whereas self-reported cognition did not [12].…”

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confidence: 99%

“…Rabin and colleagues, for example, found that informant reports provided incremental predictive power beyond episodic memory for risk of AD, whereas self-reported cognition did not [12]. Gruters and colleagues likewise found that informant-rated cognitive decline, but not self-rated decline, was a predictor of incident dementia [14]. Compared to self-reports, informants may be able to better detect changes in cognition that are indicative of pathological changes.…”

mentioning

confidence: 99%

Self-Reported Personality Traits and Informant-Rated Cognition: A 10-Year Prospective Study

Sutin

Stéphan

Terracciano

2019

JAD

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Personality traits, such as higher Neuroticism and lower Conscientiousness, are associated with risk of Alzheimer's disease and other dementias. A diagnosis of dementia relies, in part, on informant ratings of the individual's cognitive status. Here we examine whether self-reported personality traits are associated with four measures of informant-rated cognition up to a decade later. Participants from the Health and Retirement Study (N=2,536) completed a five-factor model measure of personality in 2006 or 2008. Informants completed the 2016 Harmonized Cognitive Assessment Protocol (HCAP), which included ratings of the participant's current cognitive functioning and change in cognitive function over the last decade assessed with the IQCODE, Blessed, 1066, and CSID. Controlling for characteristics of the participant, informant, and their relationship, higher Neuroticism and lower Conscientiousness were associated consistently with worse informant-rated cognition. The association between Openness and better informant-rated cognition was due primarily to higher baseline cognitive function. Extraversion and Agreeableness were associated with better informant-rated cognition only among participants who were cognitively intact at follow-up. The present research suggests that knowledgeable informants are able to detect cognitive deficits associated with personality.

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Association Between Proxy- or Self-Reported Cognitive Decline and Cognitive Performance in Memory Clinic Visitors

Cited by 20 publications

References 58 publications

Subjective age and informant-rated cognition and function: A prospective study.

Subjective age and informant-rated cognition and function: A prospective study.

Cognitive impairments in patients with persistent symptoms attributed to Lyme disease

Self-Reported Personality Traits and Informant-Rated Cognition: A 10-Year Prospective Study

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