Association between Respiratory Sleep Indices and Cardiovascular Disease in Sleep Apnea—A Community-Based Study in Cyprus

Frangopoulos, Frangiskos; Nicolaou, Ivi; Zannetos, Savvas; Economou, Nicholas-Tiberio; Adamide, Tonia; Trakada, Georgia

doi:10.3390/jcm9082475

Cited by 14 publications

(11 citation statements)

References 25 publications

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“…In our study, the SAP device also improved the parameter in patients with mild-to-moderate OSAS. The ODI was associated with hypertension [ 37 ]. Further studies should be designed for the long-term usage of the SAP device.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Smart Antisnore Pillow in Patients with Obstructive Sleep Apnea Syndrome

Chung

Lee

et al. 2021

Behavioural Neurology

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Objective. Untreated obstructive sleep apnea syndrome (OSAS) increases the risk of cardiovascular, dementia, and motor vehicle accident events. However, continuous positive airway pressure (CPAP) which is the gold standard treatment is not acceptable for many patients with OSAS. Development of devices for the patients of nonadherence to CPAP is necessary. Materials and Methods. We evaluated the effect of the smart antisnore pillow (SAP) in patients with OSAS in a prospective, noncontrolled, nonrandomized, pilot study. According to the apnea-hypopnea index (AHI), they were divided into two groups: mild-to-moderate OSAS group and severe OSAS group. Single-night polysomnography (PSG) with application of a SAP was performed. Thirty patients, 15 males and 15 females, 33–82 years old (mean age, 59.3 ± 12.9 years), completed the smart antisnore pillow therapy test. Among them, 23 patients had mild-to-moderate OSAS. Results. The SAP significantly improved the snore number ( p = 0.018 ), snore index ( p = 0.013 ), oxygen denaturation index ( p = 0.001 ), total AHI ( p = 0.002 ), and supine AHI ( p = 0.002 ) in the mild-to-moderate OSAS group, but there was no significant improvement in the severe OSAS group. Conclusions. We concluded that the SAP is an effective positional therapy device for patients with OSAS of mild-to-moderate severity.

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Section: Discussionmentioning

confidence: 99%

Efficacy of a Smart Antisnore Pillow in Patients with Obstructive Sleep Apnea Syndrome

Chung

Lee

et al. 2021

Behavioural Neurology

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“…The results of the study indicate that the severity of the sleep respiratory pathology represented by AHI is inadequate. Even with the addition of oxygenation indices for the cardiovascular manifestations of the syndrome as we demonstrated in a previous study (62) and the daytime symptoms as we proposed in this study, one is uncertain to suggest a novel classification, as there are more elements missing. Nevertheless, objective assessment using symptom questionnaires is in our opinion essential and should be compulsory, as they illuminate the sleep quality aspect and predisposition for psychic imbalance.…”

Section: Resultsmentioning

confidence: 64%

The Complex Interaction Between the Major Sleep Symptoms, the Severity of Obstructive Sleep Apnea, and Sleep Quality

et al. 2021

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Introduction: Little information exists in the general population whether clinical presentation phenotypes of obstructive sleep apnea (OSA) differ in terms of sleep quality and comorbidities.Aim: The purpose of our study was to assess possible differences between symptomatic and asymptomatic OSA patients concerning syndrome's severity, patients' sleep quality, and comorbidities.Subjects and methods: First, in a nationwide, stratified, epidemiological survey, 4,118 Cypriot adult participants were interviewed about sleep habits and complaints. In the second stage of the survey, 264 randomly selected adults underwent a type III sleep study for possible OSA. Additionally, they completed the Greek version of Pittsburgh Sleep Quality Index (Gr-PSQI), Epworth Sleepiness Scale (ESS), Athens Insomnia Scale (AIS), and Hospital Anxiety and Depression Scale (HADS).Results: From 264 enrolled participants, 155 individuals (40 females and 115 males) were first diagnosed with OSA. Among these 155 patients, 34% had ESS ≥ 10 and 49% AIS ≥ 6. One or both symptoms present categorized the individual as symptomatic (60%) and neither major symptom as asymptomatic (40%). There were no significant statistical differences (SSDs) between the two groups (symptomatic–asymptomatic) with regard to anthropometrics [age or gender; neck, abdomen, and hip circumferences; and body mass index (BMI)]. The two groups had no differences in OSA severity—as expressed by apnea–hypopnea index (AHI), oxygen desaturation index (ODI), and mean oxyhemoglobin saturation (SaO2)—and in cardiometabolic comorbidities. Symptomatic patients expressed anxiety and depression more often than asymptomatics (p < 0.001) and had poorer subjective sleep quality (Gr-PSQI, p < 0.001). According to PSQI questionnaire, there were no SSDs regarding hours in bed and the use of sleep medications, but there were significant differences in the subjective perception of sleep quality (p < 0.001), sleep efficiency (p < 0.001), duration of sleep (p = 0.001), sleep latency (p = 0.007), daytime dysfunction (p < 0.001), and finally sleep disturbances (p < 0.001).Conclusion: According to our data, OSA patients reporting insomnia-like symptoms and/or sleepiness do not represent a more severe phenotype, by the classic definition of OSA, but their subjective sleep quality is compromised, causing a vicious cycle of anxiety or depression.

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“…All willing participants (N = 4118) were interviewed by phone and answered the STOP--Bang questionnaire as previously described [30]. The STOP-Bang questionnaire is an easy touse, self-reportable, screening tool for OSA that includes eight questions of yes/no about snoring, tiredness, observed apnea, high blood pressure, BMI>35 kg/m 2 , age>50 years old, neck circumference > 40 cm, and male gender [30].…”

Section: Study Populationmentioning

confidence: 99%

The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study

et al. 2022

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Background Obstructive Sleep Apnea (OSA) is considered a public health problem and its prevalence is increasing at an epidemic rate. The aim of this study was to examine whether individual nutrients (macronutrients, antioxidant vitamins) rather than energy restriction may potentially affect OSA severity in a representative population of Cyprus. Methods A total sample of 303 adults (>18 years old) with Cypriot citizenship and permanently residing in Cyprus were randomly selected. Selected patients have completed the food frequency questionnaire, and a physical activity questionnaire and underwent a sleep study to assess OSA severity. Results Overall, 303 patients were included in this study, 169 (55.8%) had mild OSA (apnea-hypopnea index—AHI <15) and the remaining 83 (27.4%) had moderate to severe OSA (AHI>15). The mean age of all patients was 55.7 years old. Patients with moderate to severe OSA had significant higher BMI levels, higher consumption of calories, higher hip circumference, waist circumference, waist-hip ratio and neck circumference and higher consumption of folic acid compared with the patients with mild OSA (p<0.05). Conclusions The findings suggest that increased energy intake regardless diet macronutrient composition is positively associated with OSA severity whereas higher folic acid intake seems to have a protective role.

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Association between Respiratory Sleep Indices and Cardiovascular Disease in Sleep Apnea—A Community-Based Study in Cyprus

Cited by 14 publications

References 25 publications

Efficacy of a Smart Antisnore Pillow in Patients with Obstructive Sleep Apnea Syndrome

Efficacy of a Smart Antisnore Pillow in Patients with Obstructive Sleep Apnea Syndrome

The Complex Interaction Between the Major Sleep Symptoms, the Severity of Obstructive Sleep Apnea, and Sleep Quality

The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study

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