Association between serum 25(<scp>OH</scp>)D<sub>3</sub> and cardiovascular morbidity and mortality in people with Type 2 diabetes: a community‐based cohort study

Samefors, Maria; Scragg, Robert; Länne, Toste; Nyström, Fredrik; Östgren, Carl Johan

doi:10.1111/dme.13290

Cited by 18 publications

(15 citation statements)

References 36 publications

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“…In line with previously mentioned evidence, in our study survivors of MI with DM and concomitant VitD deficiency had a worse prognosis when compared to those with only DM, hypovitD or neither of them. Samefors et al [58], in a cohort of 698 patients with type 2 DM, found that low 25(OH)D3 is associated with an increased cardiovascular morbidity/mortality. In our population, diabetic patients had worse long-term outcomes when compared to non-diabetic patients, coherently with previously published data [59].…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus and Vitamin D Deficiency: Comparable Effect on Survival and a Deadly Association after a Myocardial Infarction

Aleksova

Ferro

Gagno

et al. 2020

JCM

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Survivors after a myocardial infarction (MI), especially those with diabetes mellitus (DM), remain at high risk of further events. Identifying and treating factors that may influence survival may open new therapeutic strategies. We assessed the impact on prognosis of DM and hypovitaminosis D (hypovitD), alone or combined. In this prospective, observational study, 1081 patients were enrolled surviving an MI and divided into four groups according to their diabetic and VitD status. The primary end-point was composite of all-cause mortality, angina/MI and heart failure (HF). Secondary outcomes were mortality, HF and angina/MI. During a follow-up of 26.1 months (IQR 6.6–64.5), 391 subjects experienced the primary end-point. Patients with DM or hypovitD had similar rate of the composite end-point. Patients with only hypovitD or DM did not differ regarding components of composite end-point (angina p = 0.97, HF p = 0.29, mortality p = 0.62). DM and VitD deficiency had similarly adjusted risks for primary end-point (HR 1.3, 95%CI 1.05–1.61; HR 1.3, 95% CI 1.04–1.64). The adjusted HR for primary composite end-point for patients with hypovitD and DM was 1.69 (95%CI 1.25–2.29, p = 0.001) in comparison to patients with neither hypoD nor DM. In conclusion, DM and hypovitD, individually and synergistically, are associated with a worse outcome after MI.

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Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus and Vitamin D Deficiency: Comparable Effect on Survival and a Deadly Association after a Myocardial Infarction

Aleksova

Ferro

Gagno

et al. 2020

JCM

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“…It has been suggested that vitamin D has neuroprotective properties [ 20 ] and vitamin D supplementation could be beneficial to reduce the volume of cerebral infarct in animal models of stroke [ 21 ]. Interestingly, another study reported that low 25(OH) D was associated with an increased risk of cardiovascular morbidity and mortality in people with type 2 diabetes independent of PTH [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in relation to the poor functional outcomes in nondiabetic patients with ischemic stroke

Wei

Kuang

2018

Bioscience Reports

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To assess the hypothesis that vitamin D, reflected by 25-hydroxyvitamin D (25(OH) D) would be associated with higher risk of poor functional outcomes amongst nondiabetic stroke patients. The present study was conducted in Nanchang, China. Serum concentration of 25(OH) D and National Institutes of Health Stroke Scale (NIHSS) were measured at the time of admission. Functional outcome was measured by modified Rankin scale (mRS) at 1 year after admission. Multivariate analyses were performed using logistic regression models. The cut point of 25(OH) D level for vitamin D deficiency was 20 ng/ml. In the present study, 266 nondiabetic subjects with stroke were included; 149 out of the 266 patients were defined as vitamin D deficiency (56%). The poor outcome distribution across the 25(OH) D quartiles ranged between 64% (first quartile) and 13% (fourth quartile). In those 149 patients with vitamin D deficiency, 75 patients were defined as poor functional outcomes, giving a prevalence rate of 50% (95% confidence interval (CI): 42–58%). In multivariate analysis models, for vitamin D deficiency, the adjusted risk of poor functional outcomes and mortality increased by 220% (odds ratio (OR): 3.2; 95% CI: 1.7–4.2, P<0.001) and 290% (OR: 3.9; 95% CI: 2.1–5.8, P<0.001), respectively. Vitamin D deficiency is associated with an increased risk of poor functional outcome events in Chinese nondiabetic stroke individuals.

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“…Regarding alcohol use and smoking habits, no variation was seen. The baseline characteristics regarding age, gender, anthropometric measurements, and laboratory data have been described previously [24]. Spearman's correlation coefficients between 25(OH)D 3 and key continuous variables are presented in Supplementary Table 1.…”

Section: Laboratory Methodsmentioning

confidence: 99%

“…We analyzed data from T2D patients aged 55-66 years (n = 761) who participated in a prospective observational community-based cohort study: CARDIPP (Risk factors in Patients with Diabetes-a Prospective study in Primary Care), which has been described previously [22][23][24]. The participants were consecutively recruited from 22 primary health care centers in southern Sweden.…”

Section: Participantsmentioning

confidence: 99%

Is there an association between serum 25(OH)D3 and mental well-being in patients with type 2 diabetes? Results from a cohort study in primary care

et al. 2020

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Purpose There are limited and inconsistent results on the correlation between vitamin D and mental health in patients with type 2 diabetes (T2D). Thus, our aim was to explore the association between vitamin D and mental well-being in a community-based sample of participants with T2D. Methods We analyzed serum 25-hydroxyvitamin D 3 (25(OH)D 3) in 698 patients with T2D at the baseline examination. The cohort was reinvestigated after 4 years. Data from SF-36 questionnaires measuring vitality and mental health at baseline and after 4 years were used for analyses. Results Serum 25(OH)D 3 was inversely associated with poor mental health at baseline (odds ratio (OR) for 10 nmol/l increase in 25(OH)D 3 , 0.90 (95% confidence interval (CI) 0.83-0.96, p = 0.003)) but not at follow-up (p > 0.05). Serum 25(OH)D 3 was not associated with vitality at baseline (p > 0.05). At follow-up, there was an inverse association between 25(OH)D 3 and low vitality (OR for 10 nmol/l increase in 25(OH)D 3 , 0.89 (95% CI 0.82-0.97, p = 0.009)) but not after adjustment. Conclusion We found an inverse association between 25(OH)D 3 and mental health in patients with T2D at baseline. We found no association between 25(OH)D 3 and vitality after adjustment. Future studies are needed to determine the association between vitamin D and mental well-being in patients with T2D.

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Association between serum 25(OH)D₃ and cardiovascular morbidity and mortality in people with Type 2 diabetes: a community‐based cohort study

Cited by 18 publications

References 36 publications

Diabetes Mellitus and Vitamin D Deficiency: Comparable Effect on Survival and a Deadly Association after a Myocardial Infarction

Diabetes Mellitus and Vitamin D Deficiency: Comparable Effect on Survival and a Deadly Association after a Myocardial Infarction

Vitamin D deficiency in relation to the poor functional outcomes in nondiabetic patients with ischemic stroke

Is there an association between serum 25(OH)D3 and mental well-being in patients with type 2 diabetes? Results from a cohort study in primary care

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Association between serum 25(OH)D3 and cardiovascular morbidity and mortality in people with Type 2 diabetes: a community‐based cohort study

Cited by 18 publications

References 36 publications

Diabetes Mellitus and Vitamin D Deficiency: Comparable Effect on Survival and a Deadly Association after a Myocardial Infarction

Diabetes Mellitus and Vitamin D Deficiency: Comparable Effect on Survival and a Deadly Association after a Myocardial Infarction

Vitamin D deficiency in relation to the poor functional outcomes in nondiabetic patients with ischemic stroke

Is there an association between serum 25(OH)D3 and mental well-being in patients with type 2 diabetes? Results from a cohort study in primary care

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Association between serum 25(OH)D₃ and cardiovascular morbidity and mortality in people with Type 2 diabetes: a community‐based cohort study