Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population

Nagano, Masahide; Nakamura, Motoyuki; Sato, Koetsu; Tanaka, Fumitaka; Segawa, Toshie; Hiramori, Katsuhiko

doi:10.1016/j.atherosclerosis.2004.11.019

Cited by 106 publications

(72 citation statements)

References 30 publications

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“…In contrast to the studies found in the literature, no statistically significant relationship was found between PWV and smoking, high-sensitive C-reactive protein (hs-CRP), cholesterol, triglycerides, hemoglobin and plasma phosphorous, and the total cumulative dose of phosphorous binders. 26,30,31 Consistent with the findings of Verbeke et al, 33 in our study, no relationships between the parameters of arterial stiffness/wave reflection and total cholesterol, high density lipoprotein (HDL) cholesterol, or triglycerides were found. This could be due to confounding factors such as treatments that reduce lipid levels (e.g., statins).…”

Section: Discussionsupporting

confidence: 91%

“…24,25 Many studies have pointed to a significant relationship between arterial compliance or PWV and age, male sex, height, body mass index, heart rate, blood pressure, and low density lipoprotein (LDL) cholesterol. [26][27][28][29][30][31] In the study by Löcsey et al, 32 PWV was significantly related to age and ventricular wall thickness. Additionally, PP, body mass index, SBP, and DBP correlated positively, but modestly, with PWV.…”

Section: Discussionmentioning

confidence: 96%

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Factors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patients

et al. 2011

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Background: Augmentation index (AIx) and pulse wave velocity (PWV) are early markers of atherosclerotic vascular changes and also have been shown to be predictive of cardiovascular disease and total mortality. The aim of our study was to evaluate the relationship between PWV and AIx-HR75, which is the corrected form of AIx according to a heart rate of 75 beats/min, echocardiographic parameters and biochemical parameters in chronic hemodialysis (HD) patients. Subjects and methods: AIx-HR75 and PWV were measured in 556 HD patients by applanation tonometry using the SphygmoCor device. Results: The mean PWV and AIx-HR75 values of the study group were 10.2 ± 2.4 and 28.4 ± 10.2 m/s. A positive correlation was found between PWV and AIx-HR75 (r = 0.214, p = 0.000). AIx-HR75 correlated with age (r = 0.093, p = 0.028), body surface area (BSA) (r = −0.194, p = 0.000), mean arterial pressure (MAP) (r = 0.335, p = 0.000), pulse pressure (PP) (r = 0.212, p = 0.000), cardiothoracic index (r = 0.155, p = 0.016), and presence of left ventricular hypertrophy (r = 0.152, p = 0.001). PWV correlated with MAP (r = 0.208, p = 0.000), PP (r = 0.098, r = 0.021), left ventricular mass (r = 0.105, p = 0.023), and predialysis sodium level (r = −0.105, p = 0.023). In the multivariate analyses, PWV was associated with MAP (t = 3.78, p = 0.000), presence of diabetes (t = 3.20, p = 0.001), and predialysis sodium level (t = −2.06, p = 0.040), and AIx-HR75 was associated with age (t = 2.48, p = 0.014), female sex (t = 3.98, p = 0.000), BSA (t = −2.15, p = 0.033), and MAP (t = 7.02, p = 0.000). Conclusion: There is a strong association between MAP and arterial stiffness parameters in HD patients. We feel that efficient control of blood pressure could lead to reduced arterial stiffness in HD patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Factors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patients

et al. 2011

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“…In addition, based on a study carried out in apparently healthy UK adults, Yasmin et al 17 noted CRP only to be related to PWV. In the studies of Nagano et al 18 Mattace-Raso et al 19 and Saijo et al 20 CRP was significantly and independently associated with PWV. Occasionally, the association between CRP and PWV was not retained after adjustment for cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 91%

C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community

et al. 2007

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High plasma C-reactive protein (hs-CRP) levels and arterial stiffness are risk factors for cardiovascular diseases. Pulse wave velocity (PWV) and augmentation index (AIx) have been found to be elevated in patients with vascular inflammation, diabetes mellitus, hypertension, hypercholesterolemia and in smokers. We investigated the relation of high-sensitivity CRP (hs-CRP) with aortic stiffness in 362 men. The levels of hs-CRP were measured using a nephelometric method. Aortic PWV and AIx were assessed from carotid-femoral segment and radial artery waveforms with the use of the SphygmoCor device. In the crude model, aortic PWV increased significantly with increasing serum hs-CRP levels; PWV increased by 2.48 m/s (95% CI 1.58; 3.38) in the fifth compared to the first quintile of hs-CRP. In the adjusted model, the PWV increased by 0.84 m/s (95% CI 0.13; 1.55) in the fifth quintile compared to the first quintile (P-value was 0.02). In the crude model, AIx increased significantly with increasing serum hs-CRP levels; AIx increased by 7.17% (95% CI 3.72; 10.62) in the fifth versus the first quintile. Adjusted for confounders, AIx remained 4.57% (95% CI 1.32; 7.82) higher in the fifth compared to the first quintile (P-value for trend was o0.01). More adjustment for subclinical atherosclerosis attenuated the b-coefficient for PWV (difference 0.71 m/s (95% CI 0.01; 1.41), but not for AIx (4.60% (95% CI 1.34; 7.85)). In summary, low-grade inflammation seems to be independently related to increase of aortic artery stiffness over and above traditional risk factors and atherosclerosis.

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“…Several studies indicated a significant relationship between CRP and PWV, [11][12][13][14] but one largesample-size study found no significant association. 15 Yasmin et al 12 reported that log CRP was significantly related to aortic PWV and brachial PWV in stepwise regression analysis.…”

Section: Discussionmentioning

confidence: 99%

“…There have been several studies on the relationship between CRP and arterial stiffness, but the association is controversial. Several studies indicated a significant relationship between CRP and PWV, [11][12][13][14] but one large-sample-size study found no significant association. 15 Many epidemiological studies have shown that an increased serum uric acid (UA) level is a risk factor for cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects

et al. 2005

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The relationships between C-reactive protein (CRP), uric acid (UA), glomerular filtration rate (GFR), and arterial stiffness have not been fully investigated. The aim of this study was to clarify whether CRP, UA, and estimated GFR are related to arterial stiffness estimated using brachial-ankle pulse wave velocity (baPWV). The subjects were local government employees (3412 men and 854 women). baPWV, CRP, UA, GFR, and conventional risk factors were evaluated. Multiple linear regression analyses revealed that CRP and UA were significantly related to an elevation of PWV in male and female subjects, and that the estimated GFR was significantly related to an elevation of PWV in male subjects. Significant progressive increases in baPWV were observed across the quartiles of CRP in male subjects and for UA in male and female subjects. In female subjects, the relationship of quartile CRP to baPWV had marginal significance (P ¼ 0.055). But, in male and female subjects, quartile of estimated GFR had no significant association with PWV. These results suggest that CRP and UA are associated with an increase of arterial stiffness in male and female subjects, and that estimated GFR is possibly related to arterial stiffness in male subjects.

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Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population

Cited by 106 publications

References 30 publications

Factors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patients

Factors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patients

C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community

Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects

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