Association between serum homocysteine level and unexplained infertility in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI): A retrospective, hospital‐based, case‐control study

Liu, Linli; Zhou, Lin; Lin, Peihong; Jiang, Zhongqing

doi:10.1002/jcla.23167

Cited by 12 publications

(11 citation statements)

References 25 publications

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“…This observation was in accordance with previous ndings that the pre-eclampsia women population has a higher level of TC than that in the normotensive group [14]. Serum homocysteine (HCY) has been reported to be a predict marker of pre-eclampsia and associated with IVF outcome [22,23]. In this research, although we observed an elevation of HCY level in the PE with IVF group in comparison to the PE group (P = 0.04), HCY levels in our 2 groups were both in the normal range.…”

Section: Glucose and Lipid Metabolism Were Not Signi Cantly Different...supporting

confidence: 93%

Clinical characteristics and laboratory data of pre-eclampsia patients with and without in vitro fertilization embryo transfer treatment

Liu

Zhou

et al. 2022

Preprint

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BackgroundPre-eclampsia affects around 2-10% pregnancies in the world. In vitro fertilization embryo transfer (IVF) pregnancies are associated with a 2.7-fold risk of pre-eclampsia. MethodsIn our retrospective study, 20 pre-eclampsia patients with IVF treatment (PE with IVF group) and 20 matched pre-eclampsia controls with spontaneous conception (PE group) were enrolled. We also collected several fresh decidua tissue and cord blood specimens to determine functional changes of innate immune cells at maternal-fetal interface using flow cytometry assays. ResultsThere were no obvious differences in pregnancy outcomes between 2 groups. However, maternal prealbumin (PA) level was significantly decreased while creatinine (Cr) and uric acid (UA) levels were significantly elevated in PE with IVF group. Although levels of maternal alkaline phosphatase (ALP) and cystatin C (CysC) did not differ between 2 groups, they were both abnormally elevated, exceeding the normal reference range. Moreover, significant elevations of IFN-γ and TNF-α secretions were observed in both decidual NK cells and γδT cells of pre-eclampsia patients with IVF treatment. In cord blood, productions of IFN-γ and TNF-α were only increased in the NK cells of pre-eclampsia patients with IVF treatment. ConclusionThe close surveillance for clinical features of this special pre-eclampsia population is strongly warranted.

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Section: Glucose and Lipid Metabolism Were Not Signi Cantly Different...supporting

confidence: 93%

Clinical characteristics and laboratory data of pre-eclampsia patients with and without in vitro fertilization embryo transfer treatment

Liu

Zhou

et al. 2022

Preprint

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“…Hcy, a sulfur-containing non-essential amino acid generated from the metabolism of the methionine and cysteine, plays a vital role in remethylation and trans-sulphuration. Previous studies have shown that a high serum Hcy level might lead to a reduction in the number of oocytes, suppress oocyte maturity, and reduce embryo quality (30)(31)(32). In order to reveal the correlation between AMH, PRL, Hcy, and embryo quality, a logistic regression analysis model was built for the analysis.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine Level Related to Age Is Associated With Embryo Quality in Women Who Had IVF With Diminished Ovarian Reserve

Wang

Han²,

Jiang³

et al. 2022

Front. Reprod. Health

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“…Studies have shown that Hcy is an independent risk factor for atherogenic and thrombotic components in various systems [32,33]. In recent years, it is reported that Hcy is closely related to reproduction, such as PCOS [34-36], spontaneous abortion [37,38], IVF/ICSI results [39,40], unexplained infertility [41] and male sperm concentration [42].…”

Section: Discussionmentioning

confidence: 99%

“…Dr. Liu found that although the serum Hcy level was signi cantly different between infertile patients and the normal group, it was not associated with the pregnancy outcome of IVF/ICSI. Thus, further research is needed [41]. Until up to now, there are still few studies on embryo quality and Hcy in elderly patients with DOR.…”

Section: Discussionmentioning

confidence: 99%

Serum homocysteine level is an independent risk factor for embryo quality in advanced infertility patient with diminished ovarian reserve: a large sample retrospective study

Li,

Wang,

Sun

et al. 2022

Preprint

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Backgrounds: Diminished ovarian reserve (DOR) contributes significantly to female infertility. And embryo quality is one of the decisive factors in the success of pregnancy. However, the factors that influence embryo quality in aged DOR patients are not well established. In this retrospective study, we analyzed the medical records of infertile women with DOR (aged ≥35 years old) who underwent assisted reproductive technique (ART) in our reproductive center to reveal the possible correlation between clinical characteristics and embryo quality. Methods: A total of 1063 infertile patients with DOR and aged ≥35 years old who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) were selected as subjects in the Reproductive Center of Dalian Medical Women and Children's Medical Center from January 2015 to April 2021. Patients were divided into two groups according to whether they obtained high-quality embryos (N=561 cases) or poor-quality embryos (N=502 cases). The baseline conditions of the 2 groups and the possible influencing factors of embryo quality were compared by Student's t test, Mann-Whitney U test, the chi-square or Fisher’s exact test. Multifactorial binary logistic regression analysis was created to identify statistically significant factors that can affect quality embryos in infertile women with DOR aged ≥35 years old. Finally, all patients were divided into 3 groups according to homocysteine (Hcy) levels, including subgroup A with Hcy ≤ 8 mmol/L, subgroup B with 8＜Hcy ≤15mmol/L and subgroup C with Hcy≥15mmol/L. And general indicators among three groups were compared by one-way anova with Dunnett’s multiple comparisons. And indicators related to embryo quality (number of utilizable embryos and high-quality embryos, the high-quality embryo rate) were compared by chi-square test. Results: A total of 1063 patients with DOR were included, 561 in the high-quality embryo group and 502 in the poor-quality embryo group There was significant difference in infertility years between high-quality embryo group and poor-quality embryo group (P < 0.05) except for female partner's age, male partner's age, BMI, primary and secondary infertility composition ratio, assisted reproduction method, and presence of coeliac disease) (P > 0.05). The result of univariate analysis showed that there were statistically significant differences in the starting dose of Gonadotrophin (Gn), duration of stimulation, the serum level of Hcy, the number of retrieved oocytes, the number of two pronuclei (2PN) and the number of utilizable embryos(D3) (P<0.05). The multi-factor binary regression analysis showed that the level of Hcy [OR 95% CI:0.948(0.898 to 0.999, P<0.05] and duration of stimulation [OR 95% CI:0.939(0.884 to 0.997), P<0.05] were independent risk factors for high-quality embryos. The number of fertilized oocytes (2PN), utilizable embryos (D3) and high-quality embryo (D3) was statistically different among subgroup A, B and C stratified by Hcy concentration (p<0.05). And there was significant difference in the rate of high-quality embryos among three groups stratified by Hcy concentration (P<0.05). The rate of high-quality embryos was significantly lower in subgroup C when compared with subgroup A and B (adjusted P value < 0.05). And there was no difference in the rate of high-quality embryos between subgroup A and subgroup B (adjusted P value >0.05). Conclusions: Our study was the first time to show that serum Hcy levels and duration of stimulation influence the formation of high-quality embryos negatively in aged DOR women, and high Hcy levels (≥15mmol/L) significantly reduce the ratio of high-quality embryos in aged DOR women. Our study reveals for the first time that serum Hcy levels and stimulation duration are independent risk factors for quality embryos in DOR women aged ≥35 years. And, high serum Hcy levels (≥15 mmol/L) can pose a serious threat to aged women with DOR to obtain quality embryos, which deserves the focused attention of reproductive physicians.

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Association between serum homocysteine level and unexplained infertility in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI): A retrospective, hospital‐based, case‐control study

Cited by 12 publications

References 25 publications

Clinical characteristics and laboratory data of pre-eclampsia patients with and without in vitro fertilization embryo transfer treatment

Clinical characteristics and laboratory data of pre-eclampsia patients with and without in vitro fertilization embryo transfer treatment

Homocysteine Level Related to Age Is Associated With Embryo Quality in Women Who Had IVF With Diminished Ovarian Reserve

Serum homocysteine level is an independent risk factor for embryo quality in advanced infertility patient with diminished ovarian reserve: a large sample retrospective study

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