Association Between Serum LDL-C and ApoB and SYNTAX Score in Patients With Stable Coronary Artery Disease

Lin, Ting‐Tse; Wang, Luzhao; Guo, Jane; Liu, Peng; Chen, Liheng; Wei, Mengqiu; Li, Gong-xin

doi:10.1177/0003319717748771

Cited by 17 publications

(15 citation statements)

References 29 publications

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“…In addition, significant differences were found in LDL-C levels between the three SYNTAX groups. LDL-C, ApoB and SYNTAX scores were significantly positively correlated, which is also consistent with previous research [ 36 ]. However, studies have shown that hs-Crp also correlates positively with CHD severity [ 37 ], which does not agree with results in the present study for patients with PMI.…”

Section: Discussionsupporting

confidence: 92%

Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction

et al. 2021

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Background Proprotein convertase subtilisin/kexin type 9 (Pcsk9) correlated with incidence and prognosis of coronary heart disease. However, it is unclear whether Pcsk9 contributed to coronary artery lesion severity in patients with premature myocardial infarction (PMI). The present study investigated associations between Pcsk9 and coronary artery lesion severity in PMI patients who underwent coronary angiography (CAG). Methods This prospective cohort study included young men (age ≤ 45 years, n = 332) with acute MI who underwent CAG between January 2017 and July 2019. Serum Pcsk9 levels and clinical characteristics were evaluated. SYNTAX scores (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) were calculated to quantify coronary artery lesions. Results Serum Pcsk9 levels were positively associated with SYNTAX scores (r = 0.173, P < 0.05). The diagnostic cutoff value of PSCK9 level was 122.9 ng/mL, yielding an area under the curve (AUC) of 0.63, sensitivity 81%, and specificity 40%. Serum Pcsk9, LDL-C, Apob, NT-proBnp, CK level, and diabetes history were independent predictors of high SYNTAX scores (P < 0.05). After stratifying by serum LDL-C level (cutoff = 2.6 mmol/L), medium-high Pcsk9 levels had increased risk of high SYNTAX scores in patients with high LDL-C (P < 0.05), and higher serum Pcsk9 levels had increased risk of major adverse cardiac events (MACE) after adjusting for confounding factors (P < 0.05). Conclusion Serum Pcsk9 levels correlates with severity of coronary artery lesion in PMI patients and may serve as a biomarker for severity of coronary artery stenosis in this patient population, which may contribute to risk stratification.

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Section: Discussionsupporting

confidence: 92%

Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction

et al. 2021

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“…Previous studies have shown a correlation between STX and some biochemical parameters such as hs-troponin, LDL, ApoB, procalcitonin, and hs-CRP [6][7][8]10]. In the present study, we found that high NT-proBNP levels were associated with HSTX in patients with acute MI.…”

Section: Discussionsupporting

confidence: 68%

The relationship between serum NT-proBNP levels and severity of coronary artery disease assessed by SYNTAX score in patients with acute myocardial infarction

Sarak

Karadeniz

2019

Turk J Med Sci

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Introduction Coronary artery disease (CAD) remains the most important cause of death in the world. Acute coronary syndromes (ACS) that involve ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), and unstable angina pectoris (UAP) are important lifethreatening disease groups. Various scoring systems are used for risk identification in ACS. One of these systems is the SYNTAX (STX) score, used to estimate the extent and complexity of CAD [1] and consequently early and late results [2]. This scoring system divides patients into different risk groups according to angiographic characteristics and provides foresight into the success of revascularization and early/late prognosis according to risk groups [3-5]. Previous studies have shown that high levels of hs-troponin [6], low-density lipoprotein (LDL), ApoB [7], procalcitonin [8], uric acid [9], and high-sensitivity C-reactive protein (hs-CRP) [10] are associated with high STX scores. N-terminal probrain natriuretic peptide (NT-proBNP) is a biomarker released from the myocardium due to increased myocardial stress and used for diagnosis of heart failure [11]. It has been shown that NT-proBNP was secreted by ischemic myocardium [12] and high levels of NT-proBNP are associated with poor prognosis in myocardial infarction (MI) [13,14] in patients who underwent percutaneous coronary interventions [15]. Thus, high NT-proBNP levels in patients with MI can identify patients who are at a higher risk for adverse cardiovascular events and death. However, it is not clear which mechanism plays a role in the association of high NT-proBNP levels and increased mortality and poor prognosis. The extent and severity of CAD could represent a mechanism to explain this relation. In the present study, we aimed to investigate the relationship between NT-proBNP and SYNTAX score, which is a measure of the prevalence and complexity of CAD in patients with MI. 2. Materials and methods 2.1. Ethics statement This study was approved by an institutional ethical review committee of the Faculty of Medicine, Kırıkkale University, and the reporting of the study conforms to the STROBE statement, along with references to the STROBE statement and the broader EQUATOR guidelines [16]. The study was conducted according to the principles expressed in the Declaration of Helsinki. Background/aim: In the present study, we aimed to investigate the relationship between NT-proBNP and SYNTAX score, which is a measure of the complexity of coronary artery disease. Materials and methods: We enrolled 405 consecutive patients with myocardial infarction who underwent coronary angiographic examination. Patients were divided into 3 groups according to their SYNTAX scores. Those with SYNTAX score ≤22 were included in the low SYNTAX score group (LSTX), those with a score of 23-32 were included in the intermediate SYNTAX score group (ISTX), and those with a score of ≥33 were included in the high SYNTAX score group (HSTX). Results: NT-proBNP levels were found to be significantly higher in ...

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“…A previous study has investigated the association between the lipids factors and SYNTAX score in patients with stable coronary artery disease [14]. Since vast amount of NSTEMI patients had multi-vessel disease [15, 16], the evaluation of SYNTAX score is necessary and crucial to these patients in the selection of optimal treatments.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

Chen

Yang

et al. 2019

Lipids Health Dis

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Background The study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI). Methods 311 patients with NSTEMI were enrolled. The demographic, clinical data, blood samples and SYNTAX score were documented. The Pearson linear correlation was used to detect confounding factors linearly correlated with SYNTAX score. The significantly correlated confounding factors were put into the multiple linear regressions. Results The Pearson linear correlation showed that high-density lipoprotein- cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) were significantly correlated with Syntax Score ( r = − 0.119, P = 0.044 and r = − 0.182, P = 0.002, respectively). The multiple linear regressions for Syntax Score were built using HDL-C and ApoA1, respectively. After the adjustment of other significantly correlated confounding factors such as white blood cell count (WBC), myohemoglobin (MB), glutamic-oxalacetic transaminase (AST) and creatinine, the ApoA1 still showed significant association with Syntax Score ( β = − 0.151, P = 0.028). The area under curve was (AUC) 0.624 and the optimal cutoff value is 1.07 g/L when using ApoA1 to predict moderate and severe coronary artery lesions. The patients with ApoA1 ≥ 1.07 g/L and < 1.07 g/L have the Syntax Scores of 12.21 ± 11.58 and 16.33 ± 11.53, respectively ( P = 0.001). Conclusions The ApoA1 is the only lipid factor significantly associated with complexity of coronary artery lesion in patients with NSTEMI, the patients with ApoA1 < 1.07 g/L may have more complex coronary artery lesions.

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Association Between Serum LDL-C and ApoB and SYNTAX Score in Patients With Stable Coronary Artery Disease

Cited by 17 publications

References 29 publications

Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction

Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction

The relationship between serum NT-proBNP levels and severity of coronary artery disease assessed by SYNTAX score in patients with acute myocardial infarction

Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

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