Association between serum manganese and serum klotho in a 40–80-year-old American population from NHANES 2011–2016

Guan, Guoyu; Cai, Jinming; Zheng, Songbai; Xiang, Yanzhen; Xia, Shijin; Zhang, Yixuan; Shi, Jiaqiang; Wang, Jun

doi:10.3389/fragi.2023.1120823

Cited by 7 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Potential confounders were selected a priori according to a literature review 26 , 27 . So our investigation took into account other covariates, such as gender (men/women), age (years), race (Mexican American/Other Hispanic/Non-Hispanic White/Non-Hispanic Black/Other Race—Including Multi-Racial), marital status (widowed/divorced/separated/never married/living with partner), education level (less than 9th grade/9-11th grade/high school graduate/GED or equivalent/some college or AA degree/college graduate or above), smoking (≥ 100 cigarettes in life/ < 100 cigarettes in life), alcohol (≥ 12 drinks/year/ < 12 drinks/year), diabetes (yes/no) and hypertension (yes/no), which may affect the association between SII and α-Klotho.…”

Section: Methodsmentioning

confidence: 99%

L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

Wen,

Liu,

Zhang

2024

Sci Rep

View full text Add to dashboard Cite

The systemic immune-inflammation index (SII), an integrated and ground-breaking inflammatory measure, has been widely used in various fields. We aimed to assess the association between the systemic immune-inflammation index (SII) and α-Klotho (a new anti-aging biomarker). In this cross-sectional investigation, people with complete information on SII and α-Klotho from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016 were the study's subject population. SII was calculated by platelet count × neutrophil count/lymphocyte count. The association between SII and α-Klotho was investigated using multivariable linear regression and a generalized additive model. In order to explore the non-linear connection, we employed smoothed curve fitting. Subgroup analysis were also performed. A total of 13,701 participants with an average age of 57.73 ± 10.86 years were enrolled, of whom 51.53% were female. After fully adjustment, SII was negatively associated with serum soluble α-Klotho [β(95% CI) = − 0.07 (− 0.08, − 0.05)]. Furthermore, we found L-shaped association between SII and klotho protein level, with the inflection point at 255 pg/ml. Subgroup analysis and interaction test revealed that there was no discernible dependence on gender, age, race, smoking, alcohol, diabetes and hypertension (all p for interaction > 0.05). SII level was negatively associated with serum klotho protein concentration in American adults. To verify our findings, more large-scale prospective investigations are still required.

show abstract

Section: Methodsmentioning

confidence: 99%

L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

Wen,

Liu,

Zhang

2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…At the same time, all results were checked to meet the laboratory standardized acceptability criteria before issuing the report. All pre-analyzed samples were stored at −80 degrees Celsius, and strict quality control was performed throughout the experiment [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

The Association between Dietary Fiber Intake and Serum Klotho Levels in Americans: A Cross-Sectional Study from the National Health and Nutrition Examination Survey

Liu

Wang

et al. 2023

Nutrients

View full text Add to dashboard Cite

Background: Klotho is an aging-related marker closely associated with a number of diseases. A growing body of evidence suggests that dietary factors and lifestyle habits can impact serum Klotho levels. The effect of dietary fiber, a key component of a healthy diet, on the body’s serum Klotho levels has not been fully elucidated. Objective: The aim of this study was to explore the relationship between dietary fiber intake and serum Klotho levels in people aged 40–79 years in the United States. Methods: A total of 11,282 participants were included in this study, all from the National Health and Nutrition Examination Survey from 2007 to 2016. Dietary fiber intake was assessed by uniformly trained interviewers using the 24 h dietary recall method. Serum Klotho was quantified using commercially available ELISA kits manufactured by IBL International, Japan. The relationship between dietary fiber intake and serum Klotho levels was analyzed using a multiple linear regression model. Subsequently, the non-linear dose–response relationship between the two was further explored using a restricted cubic spline (RCS) model. Results: After adjusting for potential confounders, serum Klotho levels increased by 1.9% (95% confidence interval [CI]: 0.8%, 3.0%) for each interquartile range increase in dietary fiber intake in all participants. Considering dietary fiber intake as a categorical variable, serum Klotho levels were found to be 4.7% higher in participants in the highest quartile of dietary fiber intake than in those in the lowest quartile (95% CI: 1.8%, 7.6%). RCS plots depicted a non-linear positive correlation between dietary fiber intake and serum Klotho levels. Subgroup analysis revealed that the relationship between dietary fiber intake and serum Klotho levels was more pronounced in older (percentage change: 7.0%; 95% CI: 2.5%, 11.7%) and overweight and obese participants (percentage change: 4.9%; 95% CI: 1.5%, 8.4%). Conclusions: The results of this study showed that dietary fiber intake was significantly associated with serum Klotho levels in participants. This finding is yet to be further confirmed by prospective studies.

show abstract

Association between plasma trans fatty acids and serum α-klotho levels in adults in the United States of America: an analysis of the NHANES 2009–2010 datasets

Liang,

Zhu,

Zhang

et al. 2024

Lipids Health Dis

View full text Add to dashboard Cite

Background This study aimed to explore the potential associations between trans fatty acid (TFA) and α-klotho levels. Methods Datasets from the 2009–2010 National Health and Nutrition Examination Survey (NHANES) were analysed for this study. Multivariable linear regression and restricted cubic spline (RCS) analyses were performed to examine the relationships between plasma TFA and serum α-klotho levels. Results A total of 1,205 participants were included, with a geometric mean (GM) of 803.60 (95% CI: 787.45, 820.00) pg/mL for serum α-klotho levels. RCS analysis revealed L-shaped relationships between TFA and α-klotho levels. The inflection points for palmitelaidic acid (PA), vaccinic acid (VA), elaidic acid (EA), and total TFA levels were 4.55, 20.50, 18.70, and 46.40 µmol/L, respectively. Before reaching the inflection point, serum α-klotho levels were negatively correlated with plasma PA, VA, EA and total TFA levels, with β values (95% CI) of -0.15 (-0.24, -0.06), -0.16 (-0.23, -0.09), -0.14 (-0.22, -0.05) and − 0.19 (-0.27, -0.11), respectively. Linolelaidic acid (LA) levels exhibited an inverse and linear association with α-klotho levels ( P nonlinearity =0.167, P overall <0.001). L-shaped relationships between TFA and α-klotho levels were also observed in the subgroups of participants who were aged < 65 years, were male, did not exercise, were ex-smokers, and were overweight/obese. Conclusions L-shaped correlations between plasma PA, VA, EA, and total TFA levels and serum α-klotho levels were observed among adults in the United States. Supplementary Information The online version contains supplementary material available at 10.1186/s12944-024-02226-6.

show abstract

Association between serum manganese and serum klotho in a 40–80-year-old American population from NHANES 2011–2016

Cited by 7 publications

References 44 publications

L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

The Association between Dietary Fiber Intake and Serum Klotho Levels in Americans: A Cross-Sectional Study from the National Health and Nutrition Examination Survey

Association between plasma trans fatty acids and serum α-klotho levels in adults in the United States of America: an analysis of the NHANES 2009–2010 datasets

Contact Info

Product

Resources

About