Association between serum melatonin and skin aging in an urban population of Mongolia

Nanzadsuren, Tuya; Myatav, Tuul; Dorjkhuu, Amgalanbaatar; Byamba, Khandsuren

doi:10.1111/jocd.13166

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…We used upper eyelid skin (given that it is sun-exposed and targeted by anti-aging cosmetics) from 5-6 donors (49-77 years old; mean: 61.33 years) undergoing blepharoplasty [135][136][137][138][139][140]. This age range was selected since this corresponds to the main target population for anti-aging cosmetic products and melatonin serum levels decline with age [19,141], which may render aged skin relatively deficient in melatonin signaling and potentially more responsive to exogenous melatonin stimulation.…”

Section: Methodsmentioning

confidence: 99%

Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo

Samra,

Gomez-Gomez,

Linowiecka

et al. 2023

IJMS

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Human skin aging is associated with functional deterioration on multiple levels of physiology, necessitating the development of effective skin senotherapeutics. The well-tolerated neurohormone melatonin unfolds anti-aging properties in vitro and in vivo, but it remains unclear whether these effects translate to aged human skin ex vivo. We tested this in organ-cultured, full-thickness human eyelid skin (5–6 donors; 49–77 years) by adding melatonin to the culture medium, followed by the assessment of core aging biomarkers via quantitative immunohistochemistry. Over 6 days, 200 µM melatonin significantly downregulated the intraepidermal activity of the aging-promoting mTORC1 pathway (as visualized by reduced S6 phosphorylation) and MMP-1 protein expression in the epidermis compared to vehicle-treated control skin. Conversely, the transmembrane collagen 17A1, a key stem cell niche matrix molecule that declines with aging, and mitochondrial markers (e.g., TFAM, MTCO-1, and VDAC/porin) were significantly upregulated. Interestingly, 100 µM melatonin also significantly increased the epidermal expression of VEGF-A protein, which is required and sufficient for inducing human skin rejuvenation. In aged human dermis, melatonin significantly increased fibrillin-1 protein expression and improved fibrillin structural organization, indicating an improved collagen and elastic fiber network. In contrast, other key aging biomarkers (SIRT-1, lamin-B1, p16INK4, collagen I) remained unchanged. This ex vivo study provides proof of principle that melatonin indeed exerts long-suspected but never conclusively demonstrated and surprisingly differential anti-aging effects in aged human epidermis and dermis.

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Section: Methodsmentioning

confidence: 99%

Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo

Samra,

Gomez-Gomez,

Linowiecka

et al. 2023

IJMS

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Gut microbiota and nutrient interactions with skin in psoriasis: A comprehensive review of animal and human studies

Damiani¹,

Bragazzi²,

McCormick³

et al. 2020

WJCC

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Bone Marrow Mesenchymal Stem Cells Derived from Juvenile Macaques Reversed the Serum Protein Expression Profile in Aged Macaques

Tian

et al. 2023

CSCR

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Objective: Reveal the changes of serum protein composition and content in macaques naturally ageing, and explore the effect of bone marrow mesenchymal stem cell (BMMSC) on the serum protein expression profile in elderly macaques. Methods: Naturally ageing macaques were assessed according to age. BMMSCs were intravenously infused into aged macaques. In addition, peripheral blood was collected to obtain serum for data-independent acquisition (DIA) protein sequencing to identify ageing-related indicators. One hundred eighty days after macaques received BMMSC treatment, haemoxylin and eosin (HE) staining was performed to observe the morphology and structure of aortic arches. Results: Compared with infant and young control macaques, aged macaques showed erythema on the face, dry skin, reduced amounts of hair on the head and back, and paleness. Cultured BMMSCs from the 4th passage (P4 BMMSCs) were grown in accordance with standards used to culture mesenchymal stem cells. After BMMSC treatment, the assessed aortic arches showed no calcium salt deposition or cell necrosis, and the characteristics of the serum protein expression profile tended to be similar to that of the infant and young groups, with the expression of 41 proteins upregulated with age and that of 30 proteins downregulated with age but upregulated after BMMSC treatment. Moreover, we identified 44 significantly differentially expressed proteins between the aged model and treatment groups; 11 of the upregulated proteins were related to vascular ageing, neuronal ageing and haematopoiesis, and 33 of the downregulated proteins were associated with neuronal ageing, cardiovascular disease and tumours. Interestingly, S100 expression in serum was significantly decreased, COMP expression was significantly increased, NKAP expression reappeared, and LCN2, CSF1R, CORO1C, CSTB and RSU-1 expression disappeared after BMMSC treatment. Conclusion: BMMSCs can reverse ageing-related serum protein expression.

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Association between serum melatonin and skin aging in an urban population of Mongolia

Cited by 4 publications

References 20 publications

Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo

Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo

Gut microbiota and nutrient interactions with skin in psoriasis: A comprehensive review of animal and human studies

Bone Marrow Mesenchymal Stem Cells Derived from Juvenile Macaques Reversed the Serum Protein Expression Profile in Aged Macaques

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