Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction

Abstract

Background. Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification. Aim. We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI). Methods. Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3–6)), medium (11 (9–13)) and high (20 (18–23)) tertiles of SYNTAX score. Results. Among the 378 patients included, there was a gradual increase in age, rate of diabetes, anterior wall location, and a reduction in left ventricular ejection fraction across the SYNTAX tertiles. OPG levels significantly increased across the tertiles (962 (782–1497), 1240 (870–1707), and 1464 (1011–2129) pg/mL, respectively (p < 0.001)). In multivariate analysis, OPG [OR(CI95%): 2.10 (1.29–3.49) 0.003], were associated with the high SYNTAX group, beyond hypercholesterolemia, CV history and reduced glomerular filtration rate. Conclusion. We found an association between OPG levels and coronary lesions complexity patients with acute MI.

The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods

“…In a prospective study of patients with acute myocardial infarction, Cottin et al announced an association between OPG concentration and the intensity of CAD estimated by the SYNTAX scale. A recent study showed high levels of OPG are independently associated with major damage to the myocardium after ST-elevated myocardial infarction (STEMI) [78]. A recent meta-analysis confirmed that higher levels of OPG are linked to a higher risk of death from all causes and heart disease in people with chronic kidney disease [79][80][81].…”

Relationships between Osteopontin, Osteoprotegerin, and Other Extracellular Matrix Proteins in Calcifying Arteries

“…More than a decade ago, it was observed that the concentration of OPG and OPN in serum was associated with arterial stiffness and the presence and severity of coronary artery disease [13]. Recent articles have proved that high concentrations of OPG and OPN are associated with atherosclerosis-based conditions, such as acute myocardial infarctions [14], peripheral arterial disease (PAD), or other adverse cardiovascular events [15]. The OPN and OPG concentration is higher in symptomatic or unstable atherosclerosis compared to the concentration level in cases of asymptomatic and stable atherosclerosis.…”

Causal effects for genetic variants of osteoprotegerin on the risk of acute myocardial infarction and coronary heart disease: A two-sample Mendelian randomization study

“…OPG is commonly expressed in bone cells, vascular smooth muscle cells and endothelial cells. It is widely believed that it can be used as a sensitive biomarker of vascular calcification ( 7 ). Considering the rising frequency of CHD and AMI each year, the incidence of these conditions is growing, the mortality and disability rate are also high, and more and more scholars are interested in the causes of CHD and AMI.…”

“…MI patients may benefit from the use of bone-related proteins for early risk stratification and prognosis evaluation. In patients with AMI, OPG levels are correlated with the complexity of coronary artery disease(CAD) ( 7 , 8 ). Healthy subjects with low or high coronary artery calcification cannot be distinguished by using OPG.…”