Association between serum uric acid levels and colonic diverticulosis in terms of sex

Abstract

Background The association between elevated serum uric acid (UA) levels and the risk of developing colonic diverticulosis has not yet been investigated. Thus, this cross-sectional study aimed to examine this correlation in individuals from Taiwan. Methods From Jan. 1, 2010, to Dec. 31, 2016., approximately 5,605 patients (aged >20 years) from Tri-Service General Hospital who met the inclusion criteria according to colonoscopy and laboratory test findings were included in this research. The correlation between serum UA levels and colonic diverticulosis was investigated via regression analyses. Results Participants with elevated serum UA levels were at a higher risk of colonic diverticulosis. The area under the curve for serum UA levels was significantly higher in women than in men (0.651 [95% confidence interval: 0.596–0.707] vs. 0.55 [0.507–0.593]). There were specific trends in female-specific indicators for colonic diverticulosis across increasing quartiles of serum UA levels. Conclusions Patients with elevated serum UA levels should be cautious regarding the development of colonic diverticulosis disorder in female. Moreover, prospective studies may provide additional information on the relationship between elevated serum UA levels and colonic diverticulosis.

Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness

“…Given this, we can do a case/control difference analysis for OralUreaseActivityPathways in our independent validation cohort. Here, “case” samples are defined using an aggregate of multiple systemic disease phenotypes which are based on reported associations to urea or uric acid levels in saliva (or blood) [106] , [107] , including: alcohol addiction [108] , [109] , ankylosing spondylitis [110] , diverticulosis [111] , gout [107] , hyperlipidemia [112] , [113] , kidney cyst [114] , [115] , kidney disease [116] , [117] , [118] , pancreatitis [119] , [120] . “Control” samples are selected from those lacking all disease phenotype labels in the validation cohort.…”