Association between serum uric acid and arterial stiffness in a large‐aged 40–70 years old population

Abstract

Arterial stiffness (AS), measured by arterial stiffness index (ASI), is a determinant in cardiovascular (CV) diseases. A high serum uric acid (SUA) level is a known risk factor for CV disease. The authors investigated the relationship between SUA and ASI in the middle-age UK Biobank population study. AS was defined as ASI > 10 m/s. A crosssectional study was conducted from 126 663 participants. Participants were divided into four quartiles according to SUA levels and sex. Sex multivariate analyses were performed with adjustment for confounding factors. The average ASI for overall participants was 9.3 m/s (SD: 2.9); 9.9 m/s (SD: 2.8) for men and 8.7 m/s (SD: 2.9) for women (P < .001). Men presented higher SUA rate (351.3 mmol/L (SD:67.9)) than women (270.7 mmol/L (SD:64.4)), P < .001. In men multivariate analysis, SUA remained a determinant of AS, with an increase in the strength of the association between the quartiles, Q4 versus Q1, OR = 1.10 [1.05-1.16], P < .001, Q3 versus Q1, OR = 1.09 [1.04-1.14], P < .001 but not between Q2 and Q1 (P = .136). In women, SUA remained significant for AS, with an increase in the strength of the association between the quartiles, Q4

Arterial stiffness nomogram identification by cluster analysis: A new approach of vascular phenotype modeling

“…Nevertheless, the UK Biobank used standardized protocols to collect anthropometric data; this ensures replication of data collection for all volunteers regardless of when, where and by whom they are performed and adds validity to our results. 65 Our study presents some limitations. Calculation of an ASI nomogram is dependent on the theoretical determination, which is expected to be different in another population study and potentially depends on the method used to measure ASI.…”

“…In addition, the study cohort consisted of middle‐aged European participants, so our findings cannot be generalized to other age groups and ethnic populations. Nevertheless, the UK Biobank used standardized protocols to collect anthropometric data; this ensures replication of data collection for all volunteers regardless of when, where and by whom they are performed and adds validity to our results 65 . Our study presents some limitations.…”

Sexual behaviors, cannabis, alcohol and monkeypox infection

“…Body mass index was calculated as weight (in kg) divided by height 2 (meters), and categorized as high (BMI > 30 kg/m 2 ), moderate (BMI between 25 and 30 kg/m 2 ) and low (< 25 kg/m 2 ). Cardiovascular (CV) diseases were defined by heart attack, angina and stroke, as diagnosed by a doctor and reported in the questionnaires ( 69 ). Education level was defined in three categories, high (college or university degree), intermediate (A/AS levels or equivalent, O levels/GCSEs or equivalent), and low (none of the aforementioned) ( 70 ).…”

Association between cannabis use and blood pressure levels according to comorbidities and socioeconomic status

“…5295 participants (5.8% of the study population) had a manual sphygmomanometer BP measurement. Nevertheless, automated devices measure lower BP in comparison to manual sphygmomanometers 31 , thus, and according to previous works for UK Biobank data 32 – 34 , we adjusted both SBP and DBP which were measured using the automated device using algorithms:…”