Association between serum uric acid and arterial stiffness in a low-risk, middle-aged, large Korean population

Hwang, Jiwon; Hwang, Jung Hye; Chung, Sun Mi; Kwon, Min‐Jung; Ahn, Joong Kyong

doi:10.1097/md.0000000000012086

Cited by 11 publications

(12 citation statements)

References 37 publications

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“…Some studies have shown that sUA is related to markers of increased vascular damage, such as a low ABI (34) and higher sUA levels are associated with peripheral artery disease in the US general population (35). In our study, we found such association; accordingly, several studies reported that higher sUA was associated with a low ABI in women (36,37), potentially related to estrogen effects (38)(39)(40).…”

Section: Discussionsupporting

confidence: 67%

Serum Uric Acid and Left Ventricular Mass in Essential Hypertension

Visco

Pascale

Virtuoso

et al. 2020

Front. Cardiovasc. Med.

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Serum uric acid (sUA) has been associated with cardiovascular risk. Although the recent mechanistic hypothesis poses the basis for the association between sUA and left ventricular mass index (LVMi), the issue remains poorly investigated in a clinical setup. Through a retrospective analysis of the database of the departmental Hypertension Clinic of University Hospital of Salerno Medical School, we identified 177 essential hypertensives (age 60.3 ± 13.3 years; 85 men), free from uric acid-modulating medications and severe chronic kidney disease, and whose sUA values, anthropometric, clinical, and echocardiographic data were available. In the studied cohort, the average duration of hypertension was 8.4 ± 7.1 years. LVMi associated with classical determinants, such as age, blood pressure, and kidney function, although after multivariate correction, only age remained significant. Also, sUA correlated positively with LVMi, as well as body size, metabolism, and kidney function. In a multivariate analysis, sUA confirmed the independent association with LVMi. Also, levels of sUA >5.6 mg/dl are associated with larger cardiac size. We confirmed our data in a replicate analysis performed in a larger population (1,379 hypertensives) from an independent clinic. Our results demonstrate that sUA increases with LVMi, and a cutoff of 5.6 mg/dl predict larger LV sizes. Our data suggest that hyperuricemia might help to stratify the risk of larger cardiac size in hypertensives.

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Section: Discussionsupporting

confidence: 67%

Serum Uric Acid and Left Ventricular Mass in Essential Hypertension

Visco

Pascale

Virtuoso

et al. 2020

Front. Cardiovasc. Med.

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“…The authors suggested that high UA may have unfavorable vascular effects even in low-risk populations, but they underlined the possible influence of the ethnic lifestyle on their results. 56 A previous Korean study conducted in asymptomatic healthy subjects with a mean age of 50.6 ±8.9 years who underwent a health examination failed to find any association between UA and arterial stiffness in women and men younger than 55 years. High-normal or greater UA levels were associated with an increased risk of arterial stiffness, measured as baPWV, in women older than 55 years, but not in men.…”

Section: Cross-sectional Studiesmentioning

confidence: 86%

<p>Uric Acid and Arterial Stiffness</p>

Albu¹,

Para²,

Porojan³

2020

TCRM

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Hyperuricemia is usually associated with hypertension, diabetes mellitus, metabolic syndrome and chronic kidney disease. Accumulating data from epidemiological studies indicate an association of increased uric acid (UA) with cardiovascular diseases. Possible pathogenic mechanisms include enhancement of oxidative stress and systemic inflammation caused by hyperuricemia. Arterial stiffness may be one of the possible pathways between hyperuricemia and cardiovascular disease, but a clear relationship between increased UA and vascular alterations has not been confirmed. The review summarizes the epidemiological studies investigating the relationship between UA and arterial stiffness and highlights the results of interventional studies evaluating arterial stiffness parameters in patients treated with UA-lowering drugs.

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“…These present results were in accordance with the recent case-control studies that focused on the causal relationship between uric acid and metabolic syndrome, and several cardiovascular diseases. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] However, conflicting results were still present. Parsa et al 21 reported that a decrease in serum uric acid has a causal effect of lowering blood pressure through the method of Mendelian randomization analysis in 516 Amish adults.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have reported the association between levels of circulating uric acid and arterial stiffness. 7–14 However, other studies did not find such relationship. 15,16 Observational studies have experienced residual problems of poorly measured or unmeasured confounding and reverse causality, when the disease process has a long latency period.…”

Section: Introductionmentioning

confidence: 90%

The relationship between elevated serum uric acid and arterial stiffness in a healthy population

Jiang

Zhang

et al. 2020

Vascular

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Objective This study aims to investigate the relationship between serum uric acid and arterial stiffness in a healthy population. Methods Among the 979 participants, baPWV was non-invasively measured, the circulating levels of uric acid were tested, and the uric acid polymorphisms (rs2231142 and rs11722228) were genotyped. Then, the Mendelian randomization method was employed to test the relationship between serum uric acid and arterial stiffness in a healthy population. Results After adjusting for age, gender, antihypertensive medication, body mass index, waist-to-hip ratio, urea nitrogen, creatinine and diabetic mellitus, there was a significant allelic difference in uric acid levels for each genotype ( P < 0.0001 for rs2231142; P = 0.007 for rs11722228). However, there were no differences on the potential confounders between the genotypes of rs2231142 and rs11722228 ( P > 0.05). The baPWV was significantly associated with circulating levels of uric acid after adjusting for cardiovascular risk factors and other potential confounders ( P = 0.002). However, neither the single polymorphism, nor the accumulation of culprit alleles was associated with baPWV ( P = 0.92 for rs2231142; P = 0.60 for rs11722228; P for trend = 0.77 for the combined analysis of culprit alleles). Conclusion These results do not support the causal role of circulating levels of uric acid in the development of arterial stiffness.

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Association between serum uric acid and arterial stiffness in a low-risk, middle-aged, large Korean population

Abstract: Supplemental Digital Content is available in the text

Cited by 11 publications

References 37 publications

Serum Uric Acid and Left Ventricular Mass in Essential Hypertension

Serum Uric Acid and Left Ventricular Mass in Essential Hypertension

<p>Uric Acid and Arterial Stiffness</p>

The relationship between elevated serum uric acid and arterial stiffness in a healthy population

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