Association between serum Vitamin D levels and asthma severity and control in children and adolescents

Malheiro, Ana Paula Gaban; Gianfrancesco, Lívea; Nogueira, Roberto José Negrão; Grotta, Milena Baptistella; Morcillo, André Moreno; Ribeiro, José Dirceu; Toro, Adyléia Aparecida Dalbo Contrera

doi:10.1007/s00408-023-00605-x

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…Low levels of 25(OH)D are also associated with a higher prevalence of asthma, hospitalizations, and emergency room visits due to asthma [ 33 ]. Malheiro et al found that children with vitamin D insufficiency had a higher prevalence of severe asthma [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children

Sapartini,

Wong,

Indrati

et al. 2023

Biomedicines

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Children with stunted growth have an increased risk of wheezing, and studies have shown that low levels of vitamin D and interleukin (IL)-10, along with increased IL-4 levels and CD23+ expression, are present in stunted and asthmatic children. To date, it is not known whether these factors are related to the incidence of asthma in stunted children. This case-control study investigated the association between vitamin D, IL-4, and IL-10 levels and CD23+ expression with bronchial asthma in stunted children. The study included 99 children aged 24–59 months, i.e., 37 stunted-sthmatic children (cases), 38 stunted children without asthma, and 24 non-stunted children with asthma. All children were tested for their 25(OH)D levels using chemiluminescent immunoassay (CLIA), IL-4 and IL-10 levels were measured through enzyme-linked immunosorbent assay (ELISA) testing, and CD23+ expression was measured through flow cytometry bead testing. The data were analyzed using chi-squared, Kruskal-Wallis, and Mann-Whitney tests. The results showed that stunted asthmatic children had a higher incidence of atopic family members than those without asthma. Additionally, stunted asthmatic children had a higher prevalence of vitamin D deficiency (48.6%) than the control group (44.7% and 20.8%). Furthermore, stunted asthmatic children had significantly lower levels of 25(OH)D [20.55 (16.18–25.55), p = 0.042] and higher levels of IL-4 [1.41 (0.95–2.40), p = 0.038], although there were no significant differences in IL-10 levels and CD23+ expression. The study concluded that low vitamin D and high IL-4 levels are associated with bronchial asthma in stunted children, while IL-10 and CD23+ do not show a significant association.

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Section: Discussionmentioning

confidence: 99%

The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children

Sapartini,

Wong,

Indrati

et al. 2023

Biomedicines

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“…Malheiro A.P. and collaborators found that children with severe asthma presented low concentrations of vitamin D (mean 24.28 ng/mL) in comparison to children with mild or moderate asthma (mean 27.04 ng/mL) [15]. Also, they found a positive correlation between vitamin D concentrations and lung function parameters (FEV 1 and forced expiratory flow (FEF) 25-75%) [15].…”

Section: The Relationship Between Vitamin D Insufficiency and Asthmamentioning

confidence: 97%

“…and collaborators found that children with severe asthma presented low concentrations of vitamin D (mean 24.28 ng/mL) in comparison to children with mild or moderate asthma (mean 27.04 ng/mL) [15]. Also, they found a positive correlation between vitamin D concentrations and lung function parameters (FEV 1 and forced expiratory flow (FEF) 25-75%) [15]. Likewise, a meta-analysis that includes 35 studies showed that asthmatic children presented lower 25-OHD levels (21.7 ng/mL) than healthy children (26.5 ng/mL) [16].…”

Section: The Relationship Between Vitamin D Insufficiency and Asthmamentioning

confidence: 99%

“…Its anti-inflammatory properties encompass the modulation of immune responses, particularly the regulation of pro-inflammatory cytokines linked to asthma through vitamin D receptor (VDR) signaling [10,11]. Recent epidemiological studies have reported a relationship between vitamin D deficiency/insufficiency and asthma [12][13][14][15] and that supplementation with vitamin D 3 has beneficial effects on the development and exacerbation of asthma [16,17]. Despite several advances in the field, the molecular mechanisms related to the beneficial effects of vitamin D in asthma are minimal.…”

Section: Introductionmentioning

confidence: 99%

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The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation

Hernández-Díazcouder,

Romero-Nava,

Del-Río-Navarro

et al. 2024

Nutrients

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Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway remodeling. Current epidemiological studies reported that hypovitaminosis D is frequent in patients with asthma and is associated with worsening the disease and that supplementation with vitamin D3 improves asthma symptoms. However, despite several advances in the field, the molecular mechanisms of asthma have yet to be comprehensively understood. MicroRNAs play an important role in controlling several biological processes and their deregulation is implicated in diverse diseases, including asthma. Evidence supports that the dysregulation of miR-21, miR-27b, miR-145, miR-146a, and miR-155 leads to disbalance of Th1/Th2 cells, inflammation, and airway remodeling, resulting in exacerbation of asthma. This review addresses how these molecular mechanisms explain the development of asthma and its exacerbation and how vitamin D3 may modulate these microRNAs to improve asthma symptoms.

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“…However, there is a weak positive correlation between vitamin C levels and FEV1/FVC ratio (r = 0.35; p = 0.002) [157]. A case-control study by Anand V et al revealed a higher risk of severe asthma among children lacking adequate vitamin D levels (OR 2.81, 95% CI 1.36-5.82) [160]; another observational study of 114 pediatric patients demonstrated a higher prevalence of vitamin D insufficiency in children with severe asthma compared to children with moderate asthma (p = 0.013) [161]. The results of this study are like those reported by Wu et al, who conducted a systematic review in children, and no associations were found between vitamin E supplementation and asthma [159].…”

Section: Asthmamentioning

confidence: 98%

Macronutrient and Micronutrient Intake in Children with Lung Disease

Knebusch,

Mansour,

Vazquez

et al. 2023

Nutrients

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This review article aims to summarize the literature findings regarding the role of micronutrients in children with lung disease. The nutritional and respiratory statuses of critically ill children are interrelated, and malnutrition is commonly associated with respiratory failure. The most recent nutrition support guidelines for critically ill children have recommended an adequate macronutrient intake in the first week of admission due to its association with good outcomes. In children with lung disease, it is important not to exceed the proportion of carbohydrates in the diet to avoid increased carbon dioxide production and increased work of breathing, which potentially could delay the weaning of the ventilator. Indirect calorimetry can guide the process of estimating adequate caloric intake and adjusting the proportion of carbohydrates in the diet based on the results of the respiratory quotient. Micronutrients, including vitamins, trace elements, and others, have been shown to play a role in the structure and function of the immune system, antioxidant properties, and the production of antimicrobial proteins supporting the defense mechanisms against infections. Sufficient levels of micronutrients and adequate supplementation have been associated with better outcomes in children with lung diseases, including pneumonia, cystic fibrosis, asthma, bronchiolitis, and acute respiratory failure.

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Association between serum Vitamin D levels and asthma severity and control in children and adolescents

Cited by 6 publications

References 29 publications

The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children

The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children

The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation

Macronutrient and Micronutrient Intake in Children with Lung Disease

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