Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China

Abstract

Objective: To explore the association between CETP gene polymorphisms and metabolic syndrome (MS), as well as the relationship between the CETP gene polymorphisms and each component of MS. Methods: A total of 571 individuals which were randomly selected from 5692 Uyghur adults were subdivided into two groups, including 280 patients with MS and 291 control subjects, using the group-matching method after matching for gender. We detected CETP polymorphisms (rs5882, rs1800775, rs3764261, rs12149545, rs711752, and rs708272) by using the Snapshot method. Results: (1) Significant differences were found involving the frequency distribution of genotypes and alleles of rs1800775, rs3764261, rs12149545, rs711752, and rs708272 between the control and MS groups (all p < 0.05). (2) rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms were significantly related to the risk of MS (all p < 0.05). (3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all p < 0.05). (4) Complete linkage disequilibrium (LD) was identified for two pairs of single nucleotide polymorphisms (SNPs) (rs3764261 and rs12149545 (D’ = 1.000, r2 = 0.931), rs711752 and rs708272 (D’ = 1.000, r2 = 0.996)). (5) The A-G-G-G-C (p = 0.013, odds ratio [OR] = 0.622, 95% confidence interval [95% CI] = 0.427–0.906) and A-T-A-A-T (p < 0.001, OR = 0.519, 95% CI = 0.386–0.697) haplotypes were more frequent in the control group than in the case group. Conclusions: The rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms of CETP were associated with MS and its components among the Uyghur ethnic group. Complete LD was found between two pairs of SNPs (rs3764261 and rs12149545, rs711752, and rs708272). The A-G-G-G-C and A-T-A-A-T haplotypes might be protective factors for MS.

Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis

“…Though the CETP variant did not survive conservative Bonferroni correction, we observed a strong association of rs708272 with increased HDL (ß = 4.03, p = 5.63 × 10 −40 ) and decreased TRG (ß = −2.43, p = 9.60 × 10 −5 ) levels. Consistent to our observations previous literature has shown that some variants in the CETP gene, an essential protein of reverse cholesterol transport process are associated with decreased plasma CETP protein activity and protein levels, culminating in higher concentrations of HDL 95,96 and reduced concentrations of TRG 13 . Similarly, meta-analyses have shown that carriers of the T allele, associated with lower CETP, have higher HDL concentrations than CC homozygotes 97 and thereby showing an inverse association with MetS.…”

“…This has also been observed in the genetic association studies suggesting that genetic effects on lipid levels are more pronounced than for other traits 10 . Most of the genetic association studies for MetS have been conducted in adult population 5,10,11 and are limited by the usage of one-point measurements 7,[12][13][14] . As the prevalence of MetS in children and young adults is increasing 15 , a better understanding of the genetics that underlies MetS throughout childhood and adolescence will provide critical insights into the origin of the disease.…”

High Level of Serum Cholesteryl Ester Transfer Protein and Chemerin as a Risk Factor of Metabolic Syndrome in Adolescent Obese and the Description of Cholesteryl Ester Transfer Protein −629c/A Gene Promoter Polymorphism

“…Based on genotype CETP −629 C/A gene promoter, it was also found that there was no significant relationship between AA genotypes in both groups (MS obese and non-MS obese) compared to CC genotypes against MS risk. A study by Hou et al found a significant differences involving frequency of genotypic distribution and alleles from rs1800775 (−629C/A), rs3764261, rs12149545, rs711752, and rs708272 between the control group and metabolic syndrome (all p < 0.05) [21]. The study was conducted in a minority adult population in China that included 571 subjects (280 patients and 291 controls).…”

“…The study was conducted in a minority adult population in China that included 571 subjects (280 patients and 291 controls). Our study did not conduct a separate analysis of the genotypic distribution of AA, CA, and CC, as well as the frequencies of C and A alleles between cases and controls [21]. .08], p = 0.002) ( Table 5).…”

“…There is limitation in this study that only examined 1 polymorphism (CETP -629C/A gene promoter [rs1800775]). As known, there are more than 180 SNPs in the CETP gene and 13 polymorphisms in the CETP promoter region [21], [29].…”