INTRODUCTION The function of the sweat glands appears to be impaired in patients with diabetic complications.OBJECTIVES The aim of the study was to evaluate sudomotor function in adult patients with type 1 diabetes (DM1) and healthy controls and its relationship with metabolic control and diabetic complications. .5-78.5 μS), P <0.001). In the study group, there was a negative correlation between ESC and patients' age, duration of diabetes, waist -to -hip ratio, skin autofluorescence, vibration perception threshold, as well as hemoglobin A 1c and triglyceride levels, and a positive correlation with estimated glomerular filtration rate. Microvascular complications were diagnosed in 73.3% of the patients. Patients with retinopathy, diabetic kidney disease, peripheral neuropathy, and cardiac autonomic neuropathy had lower ESC in the feet and hands compared with those without complications. In multivariate logistic regression models, ESC was associated with the presence of any microvascular complications independently of potential confounders.CONCLUSIONS Diabetic microangiopathy, and in particular neuropathy, is related with reduced sudomotor function in DM1. A longer duration of diabetes, worse metabolic control, and reduced renal function are associated with greater sudomotor dysfunction.ORIGINAL ARTICLE Sudomotor function in patients with type 1 diabetes 17 Therefore, the aim of this study was to evaluate sudomotor function using the SUDOSCAN+ device in adult patients with DM1 and healthy controls, as well as to assess the relationship of sudomotor function with metabolic control and diabetic complications.
PATIENTS AND METHODS PatientsOur study involved 404 patients (194 women) with DM1, treated at