Association Between SNPs in the One-Carbon Metabolism Pathway and the Risk of Female Breast Cancer in a Chinese Population

Wang, Xuhong; Xiong, Mengqiu; Pan, Bei; Cho, William C.; Zhou, Jin; Wang, Shukui; He, Bangshun

doi:10.2147/pgpm.s328612

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…In particular, increased risk has been reported for: breast cancer [52], cervical, ovarian or endometrial cancer [53], hepatocellular cancer [54], acute lymphoblastic leukemia and non-Hodgkin lymphoma in adults [55] and acute lymphoblastic leukemia in children [56].…”

Section: Cancermentioning

confidence: 99%

Folate Metabolism. Polymorphisms of Methylentetrahydrofolate Reductase. Concurrent Factor in Pathogenic Effects

Voyer

2023

AJBSR

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Vitamin B9, folate in its natural form is present in vegetables, fruits and organ meats. The function of folate is to act in processes of transfer one carbon compounds, methylation on nucleotides, amino acids and phospholipids, processes of vital importance for cell division, synthesis of nucleic acids, amino acids and methionine from homocysteine1. Folic acid is the synthetic form most used as a supplement to compensate low intakes of folate but has not normal biological actions if it is not converted to 5-methylenetetrahydrofolate, by the enzyme methylenetetrahydrofolate reductase. This enzyme may presents polymorphism due to mutation with biotypes of varied activity. The most commonly present, C677C and A1298A, has full activity, but C677T and T677T and A1298C and C1298C with decreased activity between 30 and 70 %, can cause metabolic alterations such as hyperhomocysteinemia and DNA hypomethylation with increased risk for chromosomal abnormalities and various pathological conditions, as neural tube development disorders, early recurrent pregnancy losses, Down syndrome, cleft lip and/or palate, limb reduction, cancer, mediterranean familial fever, polycystic ovarian syndrome and neurological or cardiovascular diseases. Faced with a history of these disorders and the presence of the aforementioned enzyme biotypes, the replacement of folic acid by L 5-methylenetetrahydrofolate supplied together with vitamin B12, B2, and B6 may reduce the risk. Beside this, with excessive intakes of folic acid, especially when low activity of the enzyme is preset, high levels in the blood can be produced, with consequently higher risk of various health problems. To avoid this, recommended intakes of folic acid should not be exceeded.

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Section: Cancermentioning

confidence: 99%

Folate Metabolism. Polymorphisms of Methylentetrahydrofolate Reductase. Concurrent Factor in Pathogenic Effects

Voyer

2023

AJBSR

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Polymorphism of folate metabolism genes in breast cancer patients

Тимофеева

Минина²,

Astafeva³

2023

HERALD of North-Western State Medical University named after I.

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Breast cancer is a widespread oncological disorder, which is considered one of the leading causes of mortality among women. DNA repair processes a well as its methylation involving genes of folate cycle play a crucial role in cancerogenesis. The aim of the study is to generalize the current data about association between polymorphic variants of folate cycle genes MTHFR С677Т (rs1801133), MTR A2756G (rs1805087), MTRR А66G (rs1801394) with risk of breast cancer development. The search of scientific papers has been conducted using PubMed and elibrary.ru sources. Original and randomized surveys published from 2008 till 2022 have been included in this review. The study has accumulated sufficient data on MTHFR С677Т polymorphic variant in breast cancer patients, having significant influence on disease development. However, the data about MTR A2756G and MTRR A66G variants is quite limited. According to the findigs of many scientific papers, there is no link between polymorphic variants of these genes and breast cancerogenesis manifestation. Such factors like ethniсity and sufficient consumption of folates with nutrition can have significant impact on results and conclusions of studies about role of folate cycle genes in breast cancer patients. Further investigation of MTHFR С677Т (rs1801133), MTR A2756G (rs1805087) and MTRR А66G (rs1801394) genetic polymorphic variants with consideration of gene-environment and gene-gene interactions could explain the presence of individual differences of breast cancer risk.

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Association Between SNPs in the One-Carbon Metabolism Pathway and the Risk of Female Breast Cancer in a Chinese Population

Cited by 2 publications

References 48 publications

Folate Metabolism. Polymorphisms of Methylentetrahydrofolate Reductase. Concurrent Factor in Pathogenic Effects

Folate Metabolism. Polymorphisms of Methylentetrahydrofolate Reductase. Concurrent Factor in Pathogenic Effects

Polymorphism of folate metabolism genes in breast cancer patients

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