Association between solitary keratoacanthoma and cigarette smoking: A case-control study

Miot, Hélio Amante; Miot, Luciane Donida Bartoli; Costa, Ana Laura Bastos da; Matsuo, Cristiane Yuri; Stolf, Hamílton Ometto; Marques, Mariângela Esther Alencar

doi:10.5070/d32wt2t8hm

Cited by 9 publications

(6 citation statements)

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“…Compared with those younger than 50 years, participants in our study who were 60 years or older had a 6-fold greater risk of developing KA. Other studies have reported the age at diagnosis to range between 64 and 71 years . In our study, men had an approximately 1.5-fold higher risk of developing KA compared with women.…”

Section: Discussionsupporting

confidence: 90%

“…In our study, men had an approximately 1.5-fold higher risk of developing KA compared with women. Other studies have reported male to female ratios ranging from 1.2:1 to 2:1 …”

Section: Discussionmentioning

confidence: 99%

“…The etiologic factors of KA are understudied, with relatively few epidemiologic studies and no large prospective studies that have captured information on exposures at baseline. The extant knowledge derives largely from case series and case-control studies, and UV radiation exposure and older age are the risk factors most frequently implicated . Although inconclusive, the suggested association with exposure to UV radiation is based on data indicating that KA commonly occurs on the limbs, that patients with fair vs darker skin have a higher frequency of tumors, that multiple KA tumors have developed after medical phototherapy, and that people with xeroderma pigmentosum have a high prevalence of KA .…”

Section: Introductionmentioning

confidence: 99%

“…The extant knowledge derives largely from case series and case-control studies, and UV radiation exposure and older age are the risk factors most frequently implicated . Although inconclusive, the suggested association with exposure to UV radiation is based on data indicating that KA commonly occurs on the limbs, that patients with fair vs darker skin have a higher frequency of tumors, that multiple KA tumors have developed after medical phototherapy, and that people with xeroderma pigmentosum have a high prevalence of KA . Other risk factors that have been associated with KA development include male sex, smoking, immunosuppression, receipt of drugs that have consequences for the cell cycle, human papillomavirus, trauma to the skin, and exposure to carcinogens, such as tar …”

Section: Introductionmentioning

confidence: 99%

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Assessment of Incidence Rate and Risk Factors for Keratoacanthoma Among Residents of Queensland, Australia

et al. 2020

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IMPORTANCE Keratoacanthoma (KA) is a common and generally benign keratinocyte skin tumor. Reports of the incidence rates of KA are scant. In addition, the risk factors for KA are not well understood, although associations with UV radiation exposure and older age have been described. OBJECTIVETo investigate the incidence rate of KA and the risk factors for developing KA. DESIGN, SETTING, AND PARTICIPANTS The study included data from 40 438 of 193 344 randomly selected residents of Queensland, Australia, who participated in the QSkin Sun and Health (QSkin) prospective population-based cohort study. All participants completed a baseline survey between 2010 and 2011 and were ages 40 to 69 years at baseline. Histopathologic reports of KA were prospectively collected until June 30, 2014, through data linkage with pathologic records. Cox proportional hazards models were used to identify risk factors associated with KA while controlling for potential confounding variables. Data were analyzed from January 2 to April 8, 2020. EXPOSURES Demographic characteristics, phenotypes, UV radiation exposure, medical history, and lifestyle. RESULTS Among 40 438 participants (mean [SD] age, 56 [8] years; 18 240 men [45.1%]), 596 individuals (mean [SD] age, 62 [6] years; 349 men [58.6%]) developed 776 KA tumors during a median follow-up period of 3.0 years (interquartile range, 2.8-3.3 years). The person-based age-standardized incidence rate for KA in the age-restricted cohort was 409 individuals per 100 000 person-years (based on the 2001 Australian population). Risk factors after adjustment for potential confounders were older age (age Ն60 years vs age <50 years; hazard ratio [HR], 6.38; 95% CI,, male sex (HR, 1.56; 95% CI, 1.33-1.84), fair skin (vs olive, dark, or black skin; HR, 3.42; 95% CI, 1.66-7.04), inability to tan (vs ability to tan deeply; HR, 1.69; 95% CI, 1.19-2.40), previous excisions of keratinocyte cancers (ever had an excision vs never had an excision; HR, 6.28; 95% CI, 5.03-7.83), current smoking (vs never smoking, HR, 2.02; 95% CI, 1.59-2.57), and high alcohol use (Ն14 alcoholic drinks per week vs no alcoholic drinks per week; HR, 1.42; 95% CI, 1.09-1.86).CONCLUSIONS AND RELEVANCE This is, to date, the first large prospective population-based study to report the incidence rate and risk factors for KA. The high person-based incidence rate (409 individuals per 100 000 person-years) highlights the substantial burden of KA in Queensland, Australia. Furthermore, the study's findings suggest that older age (Ն60 years), male sex, UV radiation-sensitive phenotypes, indications of high sun exposure (eg, previous keratinocyte cancer excisions), smoking, and high alcohol use are independent risk factors for the development of KA.

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Section: Discussionsupporting

confidence: 90%

“…In our study, men had an approximately 1.5-fold higher risk of developing KA compared with women. Other studies have reported male to female ratios ranging from 1.2:1 to 2:1 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of Incidence Rate and Risk Factors for Keratoacanthoma Among Residents of Queensland, Australia

et al. 2020

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“…This corresponds with earlier research showing that men develop more KAs than do women ( 17 , 20 , 26 ). Similar to the current study, previous reports have shown that the incidence of KA increases with age ( 15 , 17 , 20 , 27 ). Participants with KA commonly had a sun-sensitive phenotype and a past history of actinic keratoses and other keratinocyte cancers, which supports aetiological theories of high cumulative sun exposure on a background of phenotypic susceptibility (probably genetic) ( 17 , 20 , 28 – 30 ).…”

Section: Discussionsupporting

confidence: 92%

Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia

Kolmodin

Pandeya²,

Olsen³

et al. 2021

Acta Derm Venereol

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Keratoacanthomas are common keratinocyte skin tumours. However, there is little community-based data published on the clinical features of keratoacanthoma. The aim of this study was to describe the patient and tumour characteristics of keratoacanthomas, as well as their treatment patterns. Data were obtained from the QSkin Sun and Health study, a prospective cohort of 40,438 randomly sampled and consented participants aged 40–69 years in Queensland, Australia. In 2010, a baseline survey collected data, including demography, phenotype, ultraviolet radiation exposure, medical history and lifestyle. Histopathological reports of keratoacanthomas arising until 30 June 2014 were reviewed. In total, 584 participants developed 738 keratoacanthomas; 18% of participants developed multiple tumours. Common patient characteristics were male sex (58%), age ≥ 60 years (76%), fair skin (80%), and previous history of actinic keratoses/keratinocyte cancers (89%). Keratoacanthomas were commonly located on the legs/feet (48%), and rarely on the the head/neck (7%). Excision was the most frequently used surgical method (71%) Evidence of histopathological regression was reported in 67% of keratoacanthomas, suggesting a potential for spontaneous resolution in a significant proportion of keratoacanthomas.

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Epidemiology of skin cancer in the mature patient

Lai

Cranwell

Sinclair

2018

Clinics in Dermatology

116

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Association between solitary keratoacanthoma and cigarette smoking: A case-control study

Cited by 9 publications

References 0 publications

Assessment of Incidence Rate and Risk Factors for Keratoacanthoma Among Residents of Queensland, Australia

Assessment of Incidence Rate and Risk Factors for Keratoacanthoma Among Residents of Queensland, Australia

Patient and Tumour Characteristics of Keratoacanthoma in a Large, Community-based Cohort Study from Queensland, Australia

Epidemiology of skin cancer in the mature patient

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