Association Between Standardized Phase Angle, Nutrition Status, and Clinical Outcomes in Surgical Cancer Patients

Pena, Natalia Fenner; Maurício, Sílvia Fernandes; Rodrigues, Ana María; Carmo, Ariene Silva do; Coury, Nayara C.; Correia, Maria Isabel Toulson Davisson; Generoso, S.V.

doi:10.1002/ncp.10110

Cited by 52 publications

(57 citation statements)

References 39 publications

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“…A study of adult mixed solid tumor patients scheduled to undergo surgical treatment found a mean of −0.87 ± 1.43, and 28.1% of their population was SPhA <−1.65. 37 Similarly, in a study of mixed solid tumor patients about to undergo radiation therapy 27% of patients presented with SPhA <−1.65. 38 Finally, in the study of HSCT patients Note: All response for event YES.…”

Section: Discussionmentioning

confidence: 98%

“…The values of SPhA at diagnosis in our study are higher than those found in previous literature utilizing SPhA in an oncology setting. A study of adult mixed solid tumor patients scheduled to undergo surgical treatment found a mean of −0.87 ± 1.43, and 28.1% of their population was SPhA <−1.65 . Similarly, in a study of mixed solid tumor patients about to undergo radiation therapy 27% of patients presented with SPhA <−1.65 .…”

Section: Discussionmentioning

confidence: 99%

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The prognostic value of standardized phase angle in adults with acute leukemia: A prospective study

et al. 2020

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Standardized phase angle (SPhA) is a tool used to estimate body composition and cell membrane integrity. Standardized phase angle has been shown to predict survival in solid malignancies and hematopoietic stem cell transplant patients. We investigated the predictive value of SPhA on 60‐day mortality, overall survival (OS), and length of hospital stay (LHS) for adults with acute myelogenous and lymphoblastic leukemia (AML and ALL). Consecutive patients ≥18 years with newly diagnosed acute leukemia receiving intensive chemotherapy were enrolled. Phase angle measurements were taken on day 1 of therapy for all patients and on the day of nadir marrow for AML patients. Measurements were standardized by BMI, gender, and age to calculate the SPhA. The difference between SPhA at nadir bone marrow compared to day 1 of induction was used to calculate change in SPhA. A cutoff of 25th percentile was used to dichotomize baseline SPhA. Among 100 patients, 88% were AML, 56% were female, and mean age was 59 years. Though not statistically significant, OS by Kaplan‐Meier analysis was shorter for those below the 25th percentile SPhA compared to those above (median OS: 11.0 months vs 19.5 months; P = .09). Lower baseline SPhA was associated with increased incidence of 60‐day mortality in univariable (odds ratio [OR] = 5.25; 1.35, 20.44; P = .02) but not multivariable analysis (OR = 3.12; 0.67, 14.48; P = .15) adjusted for age, creatinine, and cytogenetics. Increased change in SPhA was associated with worse OS (hazard ratio = 1.15; 1.00,1.33; P = .05) in multivariable analysis. Standardized phase angle is a rapid, noninvasive, and objective measure that may be used to inform risk stratification.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

The prognostic value of standardized phase angle in adults with acute leukemia: A prospective study

et al. 2020

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“…PA has been studied by a number of authors as a biological marker to evaluate prognoses of clinical pathologies, such as a cross-sectional and prospective study that evaluated the correlation between phase angle values and nutritional and clinical variables in cirrhotic patients with a sarcopenic profile (1) . In this study, it was concluded that low PA values can be good predictors for the diagnosis of cirrhosis and suggest its use as a viable marker for sarcopenia in patients with this profile because, in addition to being an easy-access method, it offers good reproducibility and low cost (21) .…”

Section: Discussionmentioning

confidence: 99%

“…biomarker stands out, used to estimate intra and extracellular fluid, predicting with this information the cellular health, size and integrity. The measurement values of this biomarker are expressed in degrees, which commonly range from 0º to 10º, and some studies mention values up to 15º (1) .…”

Section: Introductionmentioning

confidence: 99%

Ângulo de fase para avaliar risco ou cicatrização de lesões: revisão sistemática

Mota

Chistovam²,

Moraes

et al. 2021

Online braz j nurs

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Objetivo: Avaliar a efetividade do ângulo de fase como preditor para avaliação de cicatrização de lesões cutâneas ou risco de desenvolvê-las. Método: Revisão sistemática operacionalizada segundo metodologia Joanna Briggs Institute, recomendações checklist PRISMA. Pesquisa realizada nas bases: MEDLINE, EMBASE, LILACS, CINAHL, COCHRANE, literatura cinzenta, outubro/2020. Foram incluídos estudos que avaliaram pacientes com lesão, independentemente: tipo, gravidade e patologia de base ou estudos que avaliaram o risco de desenvolvimento de alguma lesão, sendo identificados 748 artigos e selecionados 5 estudos. Resultados: Quatro estudos demonstraram o uso do ângulo de fase para o desfecho cicatrização e, um estudo apontou uma possível relação do ângulo de fase com previsão de surgimento e risco de lesão por pressão. Conclusão: Apesar de poucos trabalhos científicos com o tema proposto, conseguiu demonstrar evidência moderada para desfecho cicatrização e baixa para desfecho risco de lesão.

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“…Achado diferentes foram descritos por Axelsson et al, 12 14,15 Dindo et al, 15,16 (intervenções farmacológicas, transfusão) e 15,0% grau III, IV (internação prolongada,…”

Section: Discussionunclassified

Ângulo de fase como marcador prognóstico para o óbito e desnutrição em gastrectomias por câncer gástrico no Amazonas

Paz

Martins

Silva

et al. 2020

BJHR

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Association Between Standardized Phase Angle, Nutrition Status, and Clinical Outcomes in Surgical Cancer Patients

Abstract: SPA was associated with different nutrition status parameters, and it was able to predict postoperative infectious complications.

Cited by 52 publications

References 39 publications

The prognostic value of standardized phase angle in adults with acute leukemia: A prospective study

The prognostic value of standardized phase angle in adults with acute leukemia: A prospective study

Ângulo de fase para avaliar risco ou cicatrização de lesões: revisão sistemática

Ângulo de fase como marcador prognóstico para o óbito e desnutrição em gastrectomias por câncer gástrico no Amazonas

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