Association between TGF-Beta1 (-509) C/T Gene Polymorphism and Tissue Degradation Level In Chronic Periodontitis: A Stereological Study

Heidari, Zahra; Mahmoudzadeh‐Sagheb, Hamidreza; Sheibak, Nadia

doi:10.17795/gct-31698

Cited by 6 publications

(9 citation statements)

References 30 publications

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“…We have already reported the association between CP and cytokines SNPs[ 5 26 27 28 29 ] in Southeast of Iran. Moreover, there are two polymorphisms in MIF gene that are associated with MIF transcription level: A tetranucleotide CATT repeat at position − 794 and a SNP at position − 173 .…”

Section: Discussionmentioning

confidence: 99%

Association of macrophage migration inhibitory factor gene polymorphisms with chronic periodontitis in a South Eastern Iranian population

et al. 2017

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Background:Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. It plays a vital role in immune response against the oral disease. MIF is a regulator of innate immunity, and bacterial antigens can stimulate serum level of this protein. In experimental gingivitis, the expression level of MIF increases and this increment positively correlates with oral plaque index. The single nucleotide polymorphisms in the gene encoding the MIF protein can control the function of MIF. The aim of the present study was a clarification of the associations between MIF-173 G/C, MIF 95 bp, and 189 bp insertion/deletion (I/D) polymorphisms and chronic periodontitis (CP) compared with healthy controls.Materials and Methods:This case–control study was carried out on 210 CP patients and 100 normal subjects. MIF-173 G/C and MIF 95 bp and 189 bp I/D polymorphisms were genotyped, using polymerase chain reaction–restriction fragment-length polymorphism (PCR-RFLP) and PCR, respectively. Allele and genotype frequencies of the variants were compared between patients and controls using Chi-square. test. The value of P < 0.05 was considered statistically significant.Results:The study findings showed that MIF-173 G/C polymorphism, especially the C allele increased the risk of CP. The 95-bp I/D polymorphism was not associated with CP and the 185-bp I/D variant was not polymorphic in our population.Conclusion:Therefore, MIF-137 G/C variant increased the risk of CP in the South East of the Iranian population. In other words, polymorphisms in MIF gene influence clinical outcome of CP infection and influence the susceptibility to disease. Further studies with larger sample sizes and different ethnicities are required to validate our findings.

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Section: Discussionmentioning

confidence: 99%

Association of macrophage migration inhibitory factor gene polymorphisms with chronic periodontitis in a South Eastern Iranian population

et al. 2017

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“…Some of them have polymorphisms in their genes which have influenced the susceptibility to other chronic inflammations such as periodontal diseases Heidari et al, 2015a;Heidari et al, 2014a;Heidari et al, 2013;Heidari et al, 2015b;Heidari et al, 2014b;Sanchooli et al, 2012;Solhjoo et al, 2014). A number of cytokines such as IL-28 , IL10 have changed natural history of HBV infection.…”

Section: Cytokinesmentioning

confidence: 99%

“…TGF-β is secreted by various inflammatory cells such as macrophages during tissue injury and regulates the synthesis of connective tissue components and matrix proteins in fibroblasts and other cell types via chemotactic mechanisms (Hanafy and Ado, 2011;Heidari et al, 2015b).…”

Section: Tgf-βmentioning

confidence: 99%

“…TGF-β can induce the differentiation of fibroblasts at sites of inflammation to improve the lesions. In addition, it seems that induction of TGF-β secretion leads to increased eradication of inflammation through apoptotic mechanisms (Heidari et al, 2015b;Xiao et al, 2008).…”

Section: Tgf-βmentioning

confidence: 99%

“…It has been reported that TGF-β1 gene polymorphisms were related to the increased risk for some chronic infections and disease progression including periodontal diseases (Heidari et al, 2013;Heidari et al, 2015b;Heidari et al, 2014b) and hepatitis B and C (Hosseini Razavi et al, 2014;Liberek et al, 2009;Pereira et al, 2008;Romani et al, 2011;Suzuki et al, 2003). TGF-β1can control the production of extracellular matrix proteins therefore this cytokine has an important role in the pathogenesis and development of liver fibrosis (Gressner et al, 2002).…”

Section: Tgf-βmentioning

confidence: 99%

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Impact of host gene polymorphisms on susceptibility to chronic hepatitis B virus infection

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Immunoexpression of interferon-gamma in the interdental gingiva of chronic periodontitis patients with interferon-gamma (+874A/T) rs62559044 polymorphism

Sheibak

Heidari

Mahmoudzadeh‐Sagheb

2022

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Association between TGF-Beta1 (-509) C/T Gene Polymorphism and Tissue Degradation Level In Chronic Periodontitis: A Stereological Study

Cited by 6 publications

References 30 publications

Association of macrophage migration inhibitory factor gene polymorphisms with chronic periodontitis in a South Eastern Iranian population

Association of macrophage migration inhibitory factor gene polymorphisms with chronic periodontitis in a South Eastern Iranian population

Impact of host gene polymorphisms on susceptibility to chronic hepatitis B virus infection

Immunoexpression of interferon-gamma in the interdental gingiva of chronic periodontitis patients with interferon-gamma (+874A/T) rs62559044 polymorphism

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