Association between the CYP11B2 gene ˗344T>C polymorphism and coronary artery disease: a meta-analysis

Abstract

ABSTRACT. Numerous studies have evaluated the association between the CYP11B2 gene ˗344T>C polymorphism and coronary artery disease (CAD) risk. However, the specific association is still controversial. To address this issue, PubMed, EMBASE, and China National Knowledge Infrastructure databases were searched for eligible articles that reported on the relationship between the CYP11B2 gene ˗344T>C polymorphism and CAD, and were published before April 2014. Data from five separate studies with 3687 subjects were analyzed by meta-analysis. No significant variation in CAD risk was detected by any of the genetic models in the overall study population. Taking into account the effect of ethnicity, further stratified analyses demonstrated significant association in both Caucasian (TT vs TC: OR = 0.80, 95%CI = 0.64-1.00) and Asian populations (TT vs TC: OR = 1.25, 95%CI = 1.01-1.54; dominant model: OR = 0.80, 95%CI = 0.66-0.98). The pooled ORs were not substantially altered after the exclusion of one study in the control group that deviated from Hardy-Weinberg equilibrium, highlighting the reliability of our meta-Y. Liu et al. 3122©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 3121-3128 (2015) analysis results. In conclusion, this meta-analysis suggested that the ˗344T>C polymorphism in the CYP11B2 gene might be associated with susceptibility to CAD in Caucasians and Asians.

Association of −344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension

“…Many studies have shown a correlation between À344C/T and MACEs in different ethnicities. 22 The polymorphism was positively correlated with left ventricular mass and thickness in EH; 23,24 left ventricular hypertrophy is an important predictor of cardiovascular morbidity and mortality in patients with hypertension. 25 In a metaanalysis, Yin et al indicated that À344C/ T polymorphism might be associated with CAD in Caucasian and Asian populations.…”

“… 5 In an in vitro study, the −344C/T polymorphism in the CYP11B2 promoters was shown to affect binding of the SF-1 transcription factor and thus might influence gene expression; binding was 4 times stronger with the C allele than with the T allele. 21 Two studies 22 , 23 indicated that increased aldosterone production was associated with the C allele. Our results also demonstrated that presence of the C allele increased the risk of MACE in this Chinese EH population.…”

Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan

“…However, an association of the -344 genotype with aldosterone levels has been inconsistent, with several studies reporting an association between the -344T allele and higher levels 15 , 27 . Moreover, a meta-analysis suggested that the -344T>C polymorphism in the C YP11B2 gene might be associated with susceptibility to CAD in Caucasians and Asians 28 . However without stratification by the gender, Mishra et al reported that CYP11B2 was not associated with either CAD or left ventricular dysfunction in an Indian population 29 .…”

Aldosterone Synthase Gene (CYP11B2) Polymorphisms and Enhanced Cardiovascular Risk

“…Previous study on 201 CAD patients and 201 controls form Italian population have detected that CYP11B2 polymorphism and CC genotype were associated with CAD risk in crude analysis with borderline significance which is lost by stratification to the confounding factors as smoking and family history [82]. A meta-analysis suggested that the −344T>C polymorphism in the CYP11B2 gene might be associated with susceptibility to CAD in Caucasians and Asians [83]. A study on 609 Taiwanese male and female subjects who were unrelated and received coronary catheterization found that the C/C allele occurred more frequently in females who had CAD, and that it was associated with higher left ventricular mass (LVM) and left ventricular end diastolic diameter (LVEDD) [84].…”

“…The underlying mechanism by which the CYP11B2 ˗344T>C polymorphism can increase the risk for CAD remains unclear. However, it is related to its effect on increasing expression of CYP11B2, thereby increasing aldosterone secretion [83]. Also, the influence of gene-environment interaction has been involved as an etiological factor for CAD risk.…”