Association of −344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension

Abstract

Objective Several recent studies have shown that the aldosterone synthase gene ( CYP11B2) −344C/T polymorphism is related to cardiovascular diseases. However, whether the −344C allele influences the incidence of cardiovascular diseases in Chinese patients with hypertension is unclear. Methods Chinese patients with essential hypertension were genotyped for the −344C/T polymorphism in CYP11B2 (n = 755; CC, n = 112; CT, n = 361; TT, n = 282) and followed for 11 years for major adverse cardiovascular events (MACEs), including stroke, onset of coronary artery disease (CAD), and CAD-related death. Established cardiovascular risk factors were used to adjust the multivariate Cox analysis. Results After a mean follow-up period of 7.60 ± 1.12 years, a significantly higher incidence of MACEs was seen in patients with the CC genotype than in those with the CT and TT genotypes. The CC variant was significantly and independently predictive of MACEs (hazard ratio = 2.049), CAD (hazard ratio = 1.754), and stroke (hazard ratio = 2.588), but not CAD-related stroke or death. Conclusion The CYP11B2 −344 CC genotype is a risk factor for CAD and stroke, independent of other established cardiovascular risk factors in Chinese patients with hypertension.

Clinical Pharmacogenetics of Angiotensin II Receptor Blockers in Iraq

“…A study by Wang et al . [ 47 ] conducted in China investigated hypertensive patients and showed that the CYP11B2-344 CC genotype was an independent risk factor for coronary artery disease and stroke. [ 47 ] In contrast, Pi et al .…”

“…[ 47 ] conducted in China investigated hypertensive patients and showed that the CYP11B2-344 CC genotype was an independent risk factor for coronary artery disease and stroke. [ 47 ] In contrast, Pi et al . [ 48 ] conducted a meta-analysis in 2013 to investigate genetic susceptibility to ischemic stroke using the 344C/T polymorphism of the CYP11B2 gene, and their results did not find any relationship between the two.…”

Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?

“…The CYP11B2 gene (located on chromosome 8q24.3) encodes aldosterone synthetase (ALDOS) and is regulated by angiotensin II. Several recent studies have shown that the CYP11B2 gene rs1799998 -344C/T polymorphism is correlated with the presence of cardiovascular disease (CVD) [ 117 , 118 ]. A meta-analysis by Wang et al [ 118 ] showed that the allelic variant 344CC is a risk factor for CAD and ischemic stroke in the Chinese population [ 118 ].…”

“…Several recent studies have shown that the CYP11B2 gene rs1799998 -344C/T polymorphism is correlated with the presence of cardiovascular disease (CVD) [ 117 , 118 ]. A meta-analysis by Wang et al [ 118 ] showed that the allelic variant 344CC is a risk factor for CAD and ischemic stroke in the Chinese population [ 118 ]. The presence of the CYP11B2 -344C allele was associated with an increased risk of MI in smokers and those with dyslipidemia in a Finnish study [ 119 ].…”

Clinical pharmacogenetics of angiotensin II receptor blockers

“…В китайском исследовании с участием пациентов с артериальной гипертензией, Wang L и соавт. показали что CYP11B2 -344 CC генотип был независимым фактором риска ИБС и инсульта [40].…”