Association between the interleukin-1β C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population

Abstract

ABSTRACT. The association between the interleukin-1 beta (IL-1β) C-511T (or rs16944) polymorphism and periodontitis remains inconclusive, even though there have been previous studies on this association. To assess the effects of IL-1β C-511T variants on the risk of development of periodontitis, a meta-analysis was performed in a single ethnic population. Studies, published up to December 2015, were selected for the meta-analysis from PubMed and Chinese databases. The associations were assessed with pooled OR and 95%CI. This meta-analysis identified 8 studies, including 1276 periodontitis cases and 1558 controls. Overall, a significant association between the IL-1β C-511T polymorphism and periodontitis was found 1.68). In the subgroup analyses based on geographical area(s), source of controls, and type of periodontitis, significant results were obtained for the association between IL-1β C-511T variants and periodontitis. Our meta-analysis indicated that the IL-1β C-511T polymorphism may be a genetic susceptibility factor for periodontitis in the Chinese population. This marker could be used to identify Chinese individuals at a high risk for periodontitis.

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

“…The IL-1β rs16944 polymorphism is associated with susceptibility to periodontitis in the European 20 and the Chinese population. 26 However, another report showed no significant association between the IL-1β rs16944 polymorphism and CP susceptibility. 27 The link between the IL-1β rs1143627 polymorphism and susceptibility to periodontitis is even weaker.…”

Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility

“…We found that the IL1B -511 T/T genotype was associated to the risk of periodontitis in nonsmokers and in all subjects in this Southern Brazilian population. Previous findings had showed that the T allele was associated to periodontitis in Afro-Americans and Mulattos from the southeastern region of Brazil [68] and also in the Chinese population as shown in two meta-analysis studies [8,9]. The T/T genotype in codominant (T/T vs. C/C) and dominant (C/T + T/T vs. C/C) inheritance models were also associated to PD in Chinese [8].…”

“…Previous findings had showed that the T allele was associated to periodontitis in Afro-Americans and Mulattos from the southeastern region of Brazil [68] and also in the Chinese population as shown in two meta-analysis studies [8,9]. The T/T genotype in codominant (T/T vs. C/C) and dominant (C/T + T/T vs. C/C) inheritance models were also associated to PD in Chinese [8]. Otherwise, in a cohort study conducted in Japanese pregnant women, the -511 C/T genotype showed a protective association to periodontitis after the adjustment of the odds ratio [69].…”

“…In addition, genetic and epigenetic factors contribute to the development of PD such as individual differences in the host immune response, smoking habits, gender, poor oral-hygiene, and systemic diseases as diabetes mellitus and rheumatic diseases [1]. Genetic variants that influence the susceptibility and the severity of periodontitis arise from changes that occur in the genes and in the biological molecules that they encode [6,7] including cytokines [8][9][10][11][12][13].…”

Current understanding of genetic polymorphisms as biomarkers for risk of biological complications in implantology

“…This phenomenon has been linked to a wide range of disorders, in which there is an altered inflammatory response, such as rheumatoid arthritis, psoriasis or inflammatory bowel disease as well as other pathologies (e.g., cancer) ( 11 , 12 ). At the oral level, polymorphisms of IL-1 have been widely studied in relation to periodontal disease ( 19 ). More recently, an attempt has been made to identify whether these polymorphisms are related to an augmented risk for early dental implant failure or peri-implantitis ( 16 - 18 ).…”