Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis

Abstract

ABSTRACT. Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were retrieved. Pooled ORs with 95%CIs were calculated using fixed-or random-effect models. A total of seven case-control studies containing 2025 patients and 2174 controls were enrolled into this meta-analysis. In combined analysis, the results showed no significant association between the IL6 -174 G/C polymorphism and ischemic stroke risk in the overall population (GG vs CC: OR = 1.22, 95%CI = 0.50-3.01; TT vs TC: OR = 0.97, 95%CI = 0.81-1.15; dominant: OR = 0.98, 95%CI = 0.70-1.38; or recessive: OR = 1.24, 95%CI = 0.57-2.70) models. In the subgroup analysis by race, no significant associations between the -174 G/C 13077 Interleukin-6 -174G/C polymorphism and ischemic stroke ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13076-13083 (2015) polymorphism in the IL6 gene and ischemic stroke risk were found in Caucasians or Asians. No publication bias was found in the present study (all P > 0.05). Overall, the meta-analysis results suggested that the IL6 -174 G/C polymorphism was not associated with an increased risk of ischemic stroke. Further large and well-designed studies are needed to confirm this conclusion.

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“…Stroke is a complicated disease caused by environmental and genetic factors (Meschia et al, 2011;Jin et al, 2015). Previous studies have indicated that inflammatory cytokines and genetic polymorphisms in the genes encoding inflammatory mediators play a key role in the pathogenesis of IS (Hollegaard and Bidwell, 2006).…”

Association between aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism and susceptibility to colorectal cancer: a meta-analysis

“…Therefore, this polymorphism must be further investigated in Caucasian populations. Finally, as only studies published in English were included in this study, potential publication and language bias may occur (Jin et al, 2015).…”

Letter to the Editor Letter to editor about the article: “Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis”, published in Genet. Mol. Res. 14 (4): 13076-13083 (2015)

“…We have read a recent report by Jin et al (2015) with great interest. Basing on accessible databases and the inconsistent results in previous studies, the authors conducted a meta-analysis to better clarify the association of the IL6-174 G/C polymorphism with ischemic stroke.…”