Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals

Abstract

The levels of polyunsaturated fatty acids (PUFAs) in blood is closely associated with the status of the health of individuals; in particular, the lack of ω-3 fatty acids may lead to the development of numerous diseases. The aim of this study was to investigate the levels of PUFAs, and their correlation with triglycerides and other factors in blood. The levels of PUFAs and blood lipids were detected in 156 healthy individuals; the blood samples were tested by combined thin-layer and gas liquid chromatographic analysis. The level of ω-3 fatty acids was low in the subjects and the ω-3 index was 4.25%, while the ω-6:ω-3 ratio was at a satisfactory level. There was a strong inverse correlation between ω-3 fatty acids and triglycerides, and a strong positive correlation between ω-3 fatty acids and high density lipoprotein (HDL). Eicosapentaenoic acid and docosahexaenoic acid were inversely correlated with triglycerides, and positively correlated with HDL. In conclusion, ω-3 fatty acids are able to adjust the levels of blood lipids, and lower the levels of triglycerides, which may contribute to human health.

Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: Exploring common genetic and environmental factors

“…In agreement with an investigation based on 4 male populations (US white, Japanese American and Japanese and Korean), the strongest association was reported with large VLDL [13]. Regarding LDL variables, the non-significant relationship between n-6 PUFAs and LDL-C was also observed in Chinese residents [12] and in whites and Japanese Americans [11], but this association was significant and positive in the Japanese [11] and Italian population [10]. The greatest negative association in the present study was observed between serum n-6 PUFAs and concentrations of small LDL particles.…”

“…Overall, we show that serum n-6 PUFAs are strongly related to a favorable serum lipoprotein subclass profile in terms of cardiovascular risk. The high negative correlation obtained between n-6 PUFAs (relative proportion to total FAs) and total triglyceride concentration in our study (−0.59) was very similar to that observed in an Italian sample (−0.58) [10], and multiple regression models from the post-World War II birth cohort (ERA-JUMP) study including 3 populations (US white, Japanese American and Japanese) of middle aged men also showed an inverse relationship [11]; however, n-6 PUFAs (relative to total PUFAs) were not associated with triglycerides in the Chinese population [12]. Explained by the fact that the majority of triglyceride molecules are carried out in VLDL particles, n-6 PUFAs were strongly correlated with VLDL subclasses.…”

“…DHA can be either obtained from the diet or synthesized endogenously from alpha-linolenic acid, but since the conversion of alpha-linolenic acid to EPA is very limited (<8%) and to DHA marginal (<4%), serum concentrations of DHA can be considered as an objective biomarker of habitual fish consumption [28]. An inverse association of serum concentrations of n-3 PUFAs and DHA with triglycerides but positive with HDL-C was also observed in other populations [10–12]. We found significant inverse associations of DHA with large and medium VLDL but not with small VLDL, and positive associations with large HDL, which is in agreement with the findings of Choo et al [13].…”

“…Another study in Alaska Natives, showed that higher dietary intake of n-3 PUFAs is related to a favorable lipoprotein profile, in particular lower concentrations of large VLDL and higher concentrations of large HDL particles [9]. Concerning FAs in serum, n-6 and n-3 PUFAs have been inversely associated with triglyceride and positively with HDL-C concentrations [10,11]; however, the association with LDL-C was less consistent across populations [10–12]. In middle -aged men, serum LA was inversely associated with large VLDL, total LDL and small LDL particles as well as VLDL diameter and positively with large HDL particles and HDL diameter [13].…”

Ultra-structural Study by Transmission Electron Microscopy: Effect of Omega-3 on Ovary Cell Organelles after Experimental Induced Poly Cystic Ovary Syndrome

“…(three cis double bond) (30). Polyunsaturated fatty acids omega-3 (PUFA), particular eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), are bioactive lipids that positively impact on signalling pathways involved in the development of cardiovascular diseases, so cardioprotective action of PUFA omega-3 has been approved (31,32). Omega-3 may increase high density lipoprotein cholesterol (HDL), but it may decrease the triglyceride levels.…”