Association between the overexpression of PBOV1 and the prognosis of patients with hepatocellular carcinoma

Xue, Chengbiao; Zhong, Zibiao; Ye, Shaojun; Wang, Yanfeng; Ye, Qifa

doi:10.3892/ol.2018.9013

Cited by 6 publications

(4 citation statements)

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“…The high expression level of PBOV1 promoted G1/S transition and enhanced cell proliferation in prostate cancer (Pan et al, 2016). The function of PBOV1 was also elucidated in hepatocellular carcinoma and overexpression of PBOV1 was correlated with poor prognosis of HCC patients, indicating PBOV1 as a prognostic biomarker of HCC (Xue et al, 2018). However, there are few reports regarding the regulation of PBOV1 in tumors.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-27a-5p Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis of Wilms’ Tumor Cell by Targeting PBOV1

Guo¹,

Miao

et al. 2022

Molecular and Cellular Biology

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Section: Discussionmentioning

confidence: 99%

MicroRNA-27a-5p Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis of Wilms’ Tumor Cell by Targeting PBOV1

Guo¹,

Miao

et al. 2022

Molecular and Cellular Biology

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“…However, PBOV1 promotes prostate cancer [ 43 ] and can be a biomarker for more advanced prostate cancer [ 44 ]. High PBOV1 expression level is also a marker of poor prognosis for patients with hepatocellular carcinoma (HCC) and therapeutic target for HCC [ 45 , 46 ]. Its function in HCC may be connected with its role in epithelial-to-mesenchymal transition [ 45 , 47 ].…”

Section: Confirmation Of Non-trivial Predictionsmentioning

confidence: 99%

The Theory of Carcino-Evo-Devo and Its Non-Trivial Predictions

Kozlov

2022

Genes

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To explain the sources of additional cell masses in the evolution of multicellular organisms, the theory of carcino-evo-devo, or evolution by tumor neofunctionalization, has been developed. The important demand fora new theory in experimental science is the capability to formulate non-trivial predictions which canbe experimentally confirmed. Several non-trivial predictions were formulated usingcarcino-evo-devo theory, four of which are discussed in the present paper: (1) The number of cellular oncogenes should correspond to the number of cell types in the organism. The evolution of oncogenes, tumor suppressor and differentiation gene classes should proceed concurrently. (2) Evolutionarily new and evolving genes should be specifically expressed in tumors (TSEEN genes). (3) Human orthologs of fish TSEEN genes should acquire progressive functions connected with new cell types, tissues and organs. (4) Selection of tumors for new functions in the organism is possible. Evolutionarily novel organs should recapitulate tumor features in their development. As shown in this paper, these predictions have been confirmed by the laboratory of the author. Thus, we have shown that carcino-evo-devo theory has predictive power, fulfilling a fundamental requirement fora new theory.

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“…Prostate and breast cancer over-expressed 1 (PBOV 1) encodes for a protein which is quite over-expressed in many types of cancer but not in normal tissues ( 173 ). Nevertheless, its role in the initiation and progression of hepatocellular carcinoma (HCC), was unknown ( 174 ). In order to reveal the role of this gene in HCC, a study was carried out in which a PBOV-1 plasmid and a PBOV-1 siRNA plasmid were delivered into HCC cells so that its expression levels and its effects on growth and metastasis could be investigated.…”

Section: Most Common Cancers Treated With Gene Therapy: the Potentialmentioning

confidence: 99%

Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters

et al. 2020

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Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases, due to the lack of early diagnosis, and high relapse rate after conventional therapies. Chemotherapy inhibits the rapid growth of cancer cells, but it also affects normal cells with fast proliferation rate. Therefore, it is imperative to develop other safe and more effective treatment strategies, such as gene therapy, in order to significantly improve the survival rate and life expectancy of patients with cancer. The aim of gene therapy is to transfect a therapeutic gene into the host cells to express itself and cause a beneficial biological effect. However, the efficacy of the proposed strategies has been insufficient for delivering the full potential of gene therapy in the clinic. The type of delivery vehicle (viral or non viral) chosen depends on the desired specificity of the gene therapy. The first gene therapy trials were performed with therapeutic genes driven by viral promoters such as the CMV promoter, which induces non-specific toxicity in normal cells and tissues, in addition to cancer cells. The use of tumor-specific promoters over-expressed in the tumor, induces specific expression of therapeutic genes in a given tumor, increasing their localized activity. Several cancer- and/or tumor-specific promoters systems have been developed to target cancer cells. This review aims to provide up-to-date information concerning targeting gene therapy with cancer- and/or tumor-specific promoters including cancer suppressor genes, suicide genes, anti-tumor angiogenesis, gene silencing, and gene-editing technology, as well as the type of delivery vehicle employed. Gene therapy can be used to complement traditional therapies to provide more effective treatments.

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Association between the overexpression of PBOV1 and the prognosis of patients with hepatocellular carcinoma

Cited by 6 publications

References 20 publications

MicroRNA-27a-5p Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis of Wilms’ Tumor Cell by Targeting PBOV1

MicroRNA-27a-5p Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis of Wilms’ Tumor Cell by Targeting PBOV1

The Theory of Carcino-Evo-Devo and Its Non-Trivial Predictions

Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters

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