Association between the Oxytocin Receptor Gene Polymorphism (rs53576) and Bulimia Nervosa

Kim, Youl‐Ri; Kim, Jeong Hyun; Kim, Chan Hyung; Shin, Jae Gook; Treasure, Janet

doi:10.1002/erv.2354

Cited by 32 publications

(25 citation statements)

References 73 publications

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“…Rs237897(A) is part of a haplotype related to ASD 27 , altruism in males 30 , lower self-reported betrayal levels 71 , continuous social connectedness 72 , and Theory of Mind 18 . Alleles of rs53576 have been reported in several studies: the G allele has been reported to be implicated in Bullimia Nerviosa 73 , but also in diminished stress after social support 74 , adult separation anxiety 75 , oxytocin sensitivity in social cooperation settings (increased in males, decreased in females) 76 , overall weak social cognition skills in ADHD patients 25 and facial recognition deficits 53 . MHS rs53576(A) might be involved in AS 27, 45 , higher empathic performanc 77, 78 and social connectedness in women 31 , but also lower psychological resources such as self-esteem, optimism and emotional mastery 79 .…”

Section: Resultsmentioning

confidence: 99%

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

Theofanopoulou

Andirkó

Boeckx

et al. 2018

Preprint

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10Modern humans' lifestyle strongly depends on complex social skills like empathy, tolerance and cooperation. Variation in the oxytocin receptor (OXTR) and the arginine-vasopressin receptors (AVPR1A, AVPR1B genes) has been widely associated with diverse facets of social cognition, but the extent to which these variants may have contributed to the evolution of human prosociality remains to be elucidated. In this study, we compared the OXTR, AVPR1A and AVPR1B DNA sequences of modern humans to those of our closest extinct and extant relatives, and then clustered the variants we identified based on their distribution in the species studied. This clustering, along with the functional importance retrieved for each variant and their frequency in different modern-human populations, is then used to determine if any of the OXTR, AVPR1A and AVPR1B-variants might have had an impact at different evolutionary stages. We report a total of 29 SNPs, associated with phenotypic effects ranging from clearly pro-social to mixed or antisocial. Regarding modern human-specific alleles that could correlate with a shift towards prosociality in modern-humans, we highlight one allele in AVPR1A (rs11174811), found at high frequency and linked to prosocial phenotypes in modern humans, while the ancestral allele is associated with antisocial phenotypes. We also report three sites of putatively convergent changes between modern humans and bonobos (rs237897(A), rs2228485(G) and rs1042615(A)), and note the absence of such a convergent pattern between modern humans and chimpanzees. Finally, we observe the high concentration of 'modern human specific' alleles in vasopressin receptors not paralleled in the oxytocin receptor. 11 1 Introduction 12 Oxytocin (OXT) and vasopressin (AVP) are important neurotransmitters that function through their respective receptors to 13 regulate a diverse set of biological processes, such as pregnancy and uterine contractions, milk-ejection, copulation and orgasm, 14 attachment between mothers and their young, bond formation, suppression of stress, thermoregulation, olfactory processing, 15 eye-contact and recognition of familiar individuals 1 . OXT and AVP are closely related structurally and evolutionarily: they 16 have been argued to be the product of a local duplication event that took place before the origin of vertebrates 2 , and they only 17 differ in two (of the nine) amino acids, although they display differences at a functional level 1 . Each binds to their respective 18 receptor(s) (OXTR in the case of oxytocin, and AVPR1A, AVPR1B, and AVPR2 in the case of vasopressin), but their molecular 19 similarities allow for crosstalk in the brain and peripheral organs 3 . 20Variation in the genes that code for OXT and AVP receptors (OXTR and mainly AVPR1A and AVPR1B) have long been 21 associated with different social behaviors 4 . Single Nucleotide Polymorphisms (SNPs) in these genes in modern humans have 22 been claimed to be implicated in altruism, face recognition, stress levels and empathy, but also in socioco...

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Section: Resultsmentioning

confidence: 99%

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

Theofanopoulou

Andirkó

Boeckx

et al. 2018

Preprint

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“…Furthermore, no differences were found in basal or stimulated peripheral levels of oxytocin in women with bulimia nervosa compared with controls 65,68 . In the past 5 years, studies in women have identified associations between genetic variation in the oxytocin receptor and eating disorder diagnosis (bulimia nervosa) 70 , eating disorder thoughts and behaviours (in those with anorexia nervosa as well as a community sample of women) 71-73 , food preoccupation (in anorexia nervosa) 71 and reported nutrient intake (in a community sample of women) 72 .…”

Section: Eating Behaviourmentioning

confidence: 99%

The effects of oxytocin on eating behaviour and metabolism in humans

2017

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“…Two recent studies have investigated associations between OXT‐R genetic variants and ED. In particular, a Korean study showed a positive association between the G allele of rs53576 and bulimia nervosa (BN) in a clinical sample of 90 women with BN compared to controls ( n = 103) (Kim, Kim, Kim, Shin, & Treasure, 2015). Amongst patients with AN, AN (weight‐recovered), BN and controls (overall n = 124), subjects with rs53576 and rs2254298 GG/GG haplotype had lower scores on overall ED psychopathology measures, less body shape and food preoccupation, fewer obsessive compulsive behaviours, and lower anxiety (Acevedo, Valencia, Lutter, & McAdams, ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women

Micali

Crous‐Bou

Treasure

et al. 2016

Euro Eating Disorders Rev

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This study aimed to investigate associations between oxytocin receptor gene (OXT‐R) polymorphisms (rs53576 and rs2254298), their interaction with maternal care (GxE), and ED behaviours in a community sample. We studied 3698 women from the Avon Longitudinal Study of Parents and Children (ALSPAC) who participated in a two‐phase prevalence study of lifetime ED and had genotype data. The GG rs53576 genotype was associated with binge eating and purging, and the rs2254298 AG/AA genotype with restrictive eating lifetime. In addition, the rs2254298 AG/AA genotype interacted with poor maternal care to increase the odds of binge eating and purging (odds ratio = 4.40 (95% confidence intervals: 1.11–17.4)). This study replicates previous findings of an association between OXT‐R polymorphisms and ED, and it is the first to show an interaction between OXT‐R genotype and poor maternal care. As such, these findings highlight the important role of oxytocin in understanding the pathophysiology of ED. © 2016 The Authors European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd

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Association between the Oxytocin Receptor Gene Polymorphism (rs53576) and Bulimia Nervosa

Abstract: These findings suggest the involvement of the oxytocinergic system in the mechanism that underlies BN.

Cited by 32 publications

References 73 publications

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

Oxytocin and vasotocin receptor variation sheds light into the evolution of human prosociality

The effects of oxytocin on eating behaviour and metabolism in humans

Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women

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