Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population

Abstract

ABSTRACT. Although a number of studies have been conducted on the association between the peptidylarginine deiminase (PADI4) -94G/A polymorphism and rheumatoid arthritis (RA) in the Chinese population, the association remains elusive and controversial. To clarify the impact of the PADI4 -94G/A polymorphism on the risk of RA, a meta-analysis was performed in the Chinese population. Related studies were identified from databases such as, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to May 21, 2015. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. A total of 10 studies with 2783 RA cases and 2887 controls were included in this meta-analysis. Overall, a significantly elevated risk of RA was associated with all variants of PADI4 -94G/A (A vs G: OR = 1.24, 95%CI = 1.15-1.34; AA + GA vs GG: OR = 1.45, 95%CI = 1.29-1.62; AA vs GG: OR = 1.49, 95%CI = 1.28-1.73; AA vs GG + GA: OR = 1.19, 95%CI = 1.04-1.35). Subgroup analyses stratified by geographic areas and source of controls revealed significant results in the populationbased studies in North and South China. In conclusion, this meta-analysis showed that the PADI4 -94G/A variants may influence RA risk in the Chinese population. However, further studies with gene-gene and geneenvironment interactions are required for definite conclusions.

The Relationship Between Padi4 -94G/A Polymorphism and Rheumatoid Arthritis: A Meta-analysis in Multi Ethnic Groups

“…Since the rst positive association between PADI − 94G/A and RA was reported in a Japanese population [15], a number of studies have reported the association between PADI − 94G/A polymorphisms and RA risk in different populations. Till now, there are several published meta-analyses regarding PADI4 -94G/A polymorphisms and RA risk [25][26][27][28][29][30]. Of these, two meta-analyses reported that there was signi cant association between PADI4 -94G/A polymorphism and RA risk both in Asian and European population [26,28], while two metaanalyses reported that there was signi cant association only in Asian individuals [27,29].…”

“…Of these, two meta-analyses reported that there was signi cant association between PADI4 -94G/A polymorphism and RA risk both in Asian and European population [26,28], while two metaanalyses reported that there was signi cant association only in Asian individuals [27,29]. However, only one meta-analysis was conducted in a separate ethnic group [30]. Therefore, we performed this metaanalysis to assess the relationship between PADI − 94G/A polymorphism and RA risk in multi ethnic groups respectively.…”

“…In the subgroup analyses by ethnicity, signi cant association was found in China as well as in Japan and USA. Compared with the previous meta-analyses [25][26][27][28][29][30], the current study involved more research in multi ethnic groups. And the effects of gene-environment interactions with respect to RA risk were also conducted by each separate ethnic group analysis.…”