Association between the Polymorphisms in Intercellular Adhesion Molecule-1 and the Risk of Coronary Atherosclerosis: A Case-Controlled Study

Yang, Mingliang; Fu, Zhenkun; Zhang, Qingjiang; Yu, Xin; Chen, Yan-Jun; Tian, Ye

doi:10.1371/journal.pone.0109658

Cited by 12 publications

(7 citation statements)

References 33 publications

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“…In addition to its association with sICAM1 levels, the ICAM1 SNP rs5498 has been shown to associate with a plethora of diseases in Asians including diabetic microvascular complications [37], proliferative diabetic retinopathy [38], oral carcinogenesis [39], migraine [40], and coronary atherosclerosis [41]. Because rs5498 encodes a lysine-to-glutamic acid mutation at position 469 (K469E) which alters the electrostatic property of the binding site for ICAM1’s ligand LFA-1 [42], it is likely that changes in ICAM1’s affinity to LFA-1 contribute to the inflammation-related diseases.…”

Section: Discussionmentioning

confidence: 99%

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Teng

et al. 2017

PLoS ONE

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Intercellular adhesion molecule–1 (ICAM1) is crucial to the development and progression of atherosclerosis. Recent genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) in two of the nuclear factor-κB (NF-κB) pathway genes, NFKBIK and RELA, are associated with soluble ICAM1 (sICAM1) levels. However, neither of these two gene variants is found in the Asian populations. This study aimed to elucidate whether other candidate gene variants involved in the NF-κB pathway may be associated with sICAM1 levels in Taiwanese. After excluding carriers of the ICAM1 rs5491-T allele, three SNPs in the ICAM1 gene and eight SNPs in six of the NF-κB pathway genes (NFKB1, PDCD11, TNFAIP3, NKAPL, IKBKE, and PRKCB) were analyzed for their association with sICAM1 levels in 480 individuals. Our data showed that two SNPs, rs5498 of ICAM1 and rs1635 of NKAPL, were significantly associated with sICAM1 levels (P = 0.002 and 0.004, respectively) in the Taiwanese population. Using a multivariate analysis, rs5498 and rs1635 as well as the previously reported ABO genotypes and rs12051272 of the CDH13 gene were independently associated with sICAM1 levels (P = 0.001, 0.001, 0.006 and 0.031, respectively). An analysis with combined risk alleles of four candidate SNPs in the ICAM1, NKAPL, ABO, and CDH13 genes showed an increase in sICAM1 levels with added numbers of risk alleles and weighted genetic risk score. Our findings thus expanded the repertoire of gene variants responsible for the regulation of sICAM1 levels in the Asian populations.

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Section: Discussionmentioning

confidence: 99%

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Teng

et al. 2017

PLoS ONE

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“…It is well-documented that IL-6, ICAM-1 and MCP-1 are multifunctional micro-inflammatory cytokines involved in immune and inflammatory responses produced by a variety of cells in vivo [ 41 , 42 ]. Recent and previous studies demonstrated that the plasma IL-6, ICAM-1, C-reactive protein (CRP) and TNF-α level increased in patients with hypertension, and further rise with the degree of renal damage, suggesting that micro-inflammatory cytokines involved in the development of hypertensive renal damage [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation

Xue

Cao

et al. 2016

Bioscience Reports

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SynopsisMicro-inflammation plays an important role in the pathogenesis of spontaneously hypertensive rat (SHR). In the present study, we investigated the therapeutic potential of resveratrol (RSV), a polyphenol with anti-fibrosis activity in hypertensive renal damage model. In SHR renal damage model, RSV treatment blunted the increase in urine albumin excretion, urinary β 2 -microglobulin (β 2 -MG), attenuated the decrease in creatinine clearance rate (CCR). The glomerular sclerosis index (1.54 + − 0.33 compared with 0.36 + − 0.07) and tubulointerstitial fibrosis (1.57 + − 0.31 compared with 0.19 + − 0.04) were significantly higher in SHRs compared with Wistar Kyoto rats (WKYs), which were significantly lower by RSV treatment. The increases in mesangium accumulation and the expression of renal collagen type I (Col I), fibronectin (Fn), plasminogen activator inhibitor-1 (PAI-1) and transforming growth factor-β1 (TGF-β1) in SHR were also reduced by RSV treatment. Nuclear factor κB (NF-κB) expression was increased in the cytoplasm and nuclei of the SHR kidneys, which was significantly decreased by RSV treatment. Furthermore, the protein level of IκB-α significantly decreased in the kidneys of the SHR when compared with the WKYs. RSV treatment partially restored the decreased IκB-α level. In SHR kidney, increased expression of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein 1 (MCP-1) were observed. These changes were attenuated by RSV treatment. No changes in blood pressure were detected between SHR group and SHR + RSV group. Taken together, the present study demonstrated that RSV treatment may significantly attenuate renal damage in the SHR model of chronic kidney disease (CKD). The renal protective effect is associated with inhibition of IL-6, ICAM-1 and MCP-1 expression via the regulation of the nuclear translocation of NF-κB, which suggesting that micro-inflammation may be a potential therapeutic target of hypertensive renal damage.Key words: inflammation, intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), nuclear factor κB (NF-κB), resveratrol (RSV), spontaneously hypertensive rat (SHR).

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“…In Swedish Caucasians, the C allele of rs281432 was significantly associated with type 1 diabetes ( Ma et al 2006 ). In a recent study in a Chinese population, Yang et al (2014) found a significantly higher frequency of a three-allele haplotype containing the rs281432 G allele in coronary atherosclerosis cases, and the G allele was associated with a significantly higher level of triglycerides. Bielinski et al (2008 , 2011 ) reported that, in Chinese and African Americans, individuals carrying the rs281432 GG genotype had higher circulating levels of sICAM-1 compared with those with the CC genotype.…”

Section: Discussionmentioning

confidence: 91%

“…Findings of the present study support a role of endothelial dysfunction in the underlying mechanisms of the cardiovascular effects of As exposure. Specifically, ICAM1 rs281432 is an intronic SNP that has been studied in diabetes and subclinical atherosclerosis, although findings have been mixed ( Bielinski et al 2008 ; Ma et al 2006 ; Yang et al 2014 ). For instance, in the Multi-Ethnic Study of Atherosclerosis, Bielinski et al (2008) observed no association between rs281432 and subclinical atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Interaction between Arsenic Exposure from Drinking Water and Genetic Polymorphisms on Cardiovascular Disease in Bangladesh: A Prospective Case-Cohort Study

Jasmine

Kibriya

et al. 2015

Environ Health Perspect

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Background: Epidemiologic data on genetic susceptibility to cardiovascular effects of arsenic exposure from drinking water are limited.Objective: We investigated whether the association between well-water arsenic and cardiovascular disease (CVD) differed by 170 single nucleotide polymorphisms (SNPs) in 17 genes related to arsenic metabolism, oxidative stress, inflammation, and endothelial dysfunction.Method: We conducted a prospective case-cohort study nested in the Health Effects of Arsenic Longitudinal Study, with a random subcohort of 1,375 subjects and 447 incident fatal and nonfatal cases of CVD. Well-water arsenic was measured in 2000 at baseline. The CVD cases, 56 of which occurred in the subcohort, included 238 coronary heart disease cases, 165 stroke cases, and 44 deaths due to other CVD identified during follow-up from 2000 to 2012.Results: Of the 170 SNPs tested, multiplicative interactions between well-water arsenic and two SNPs, rs281432 in ICAM1 (padj = 0.0002) and rs3176867 in VCAM1 (padj = 0.035), were significant for CVD after adjustment for multiple testing. Compared with those with GC or CC genotype in rs281432 and lower well-water arsenic, the adjusted hazard ratio (aHR) for CVD was 1.82 (95% CI: 1.31, 2.54) for a 1-SD increase in well-water arsenic combined with the GG genotype, which was greater than expected given aHRs of 1.08 and 0.96 for separate effects of arsenic and the genotype alone, respectively. Similarly, the joint aHR for arsenic and the rs3176867 CC genotype was 1.34 (95% CI: 0.95, 1.87), greater than expected given aHRs for their separate effects of 1.02 and 0.84, respectively.Conclusions: Associations between CVD and arsenic exposure may be modified by genetic variants related to endothelial dysfunction.Citation: Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Jiang J, Roy S, Paul-Brutus R, Slavkovich V, Islam T, Levy D, VanderWeele TJ, Pierce BL, Graziano JH, Ahsan H, Chen Y. 2015. Interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh: a prospective case-cohort study. Environ Health Perspect 123:451–457; http://dx.doi.org/10.1289/ehp.1307883

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Association between the Polymorphisms in Intercellular Adhesion Molecule-1 and the Risk of Coronary Atherosclerosis: A Case-Controlled Study

Cited by 12 publications

References 33 publications

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation

Interaction between Arsenic Exposure from Drinking Water and Genetic Polymorphisms on Cardiovascular Disease in Bangladesh: A Prospective Case-Cohort Study

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