Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia

Lorenzo, C. Vaquero; Baca‐García, Enrique; Díaz-Hernández, Montserrat; Botillo-Martin, Carlota; Perez‐Rodriguez, M. Mercedes; Fernández-Ramos, C.; Saiz-Gonzalez, M.D.; Quintero-Gutierrez, F.J.; Sáiz-Ruiz, Jerónimo; Piqueras, José Fernández; Rivera, Luis de; Leon, José de

doi:10.1016/j.pnpbp.2006.04.027

Cited by 22 publications

(10 citation statements)

References 24 publications

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“…5-HTR has been reported to play an important role in vasoconstriction and proliferation of vessel walls [29]. The c.102T→C polymorphism of the 5-HTR2A gene has been associated systemic arterial hypertension [30,31,32] but has not been investigated in PH. Therefore, we decided to include this gene in our analysis.…”

Section: Introductionmentioning

confidence: 99%

Sequence Variants in <i>BMPR2</i> and Genes Involved in the Serotonin and Nitric Oxide Pathways in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Relation to Clinical Parameters and Comparison with Left Heart Disease

et al. 2009

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Background: Idiopathic pulmonary arterial hypertension (IPAH) and chronic thromboembolic pulmonary hypertension (CTEPH) share important pathogenic and clinical features. BMPR2 mutations are important in the pathogenesis of IPAH, but little is known about the genetic background in CTEPH. Objective: To search for mutations and polymorphisms in genes involved in the BMPR2, serotonin and nitric oxide pathways possibly associated with pulmonary and cardiac disorders in IPAH and CTEPH. Methods: In a cohort of Swiss patients with IPAH (n = 16) and CTEPH (n = 16), and in 24 controls with left heart disease without PH, polymorphisms in the BMPR2, 5-HHT, 5-HTR-2A and eNOS genes were analyzed and correlated with various clinical, functional and hemodynamic parameters. Results: We found a BMPR2 missense mutation in a patient with coronary artery disease (CAD) without PH but no BMPR2 mutations in our collective with late-onset sporadic PH. In patients with polymorphic variants of the BMPR2 gene, the number of blood platelets and oxygen saturation were increased. The c.600A→C synonymous variant was associated with worse exercise capacity and decreased quality of life in PH. We found no significant differences for any measured parameter according to the eNOS, 5-HTR2A and the 5-HTT polymorphisms, although there was a higher allelic frequency of the 5-HTT long variant in IPAH than in CTEPH and controls. Conclusion: Our first report of a BMPR2 mutation in a patient with CAD without PH is interesting and warrants further investigation. Our study may reflect the clinical status and genetic background in a typical PH cohort as seen in a single tertiary care referral center.

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Section: Introductionmentioning

confidence: 99%

Sequence Variants in <i>BMPR2</i> and Genes Involved in the Serotonin and Nitric Oxide Pathways in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Relation to Clinical Parameters and Comparison with Left Heart Disease

et al. 2009

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“…Given that the T102C polymorphism has been previously associated with schizophrenia, the fact that we found no significant differences in the frequencies of T102C genotypes between suicide attempters and psychiatric controls may be partially explained by the high rates of psychotic disorders among psychiatric controls (115/339, 35.8%), [Williams et al, 1997; Abdolmaleky et al, 2004; Vaquero Lorenzo et al, 2006]. The fact that there were significant differences in the rates of almost all psychiatric disorders analyzed between suicide attempters and psychiatric controls (Table I) may confound the results.…”

Section: Psychiatric Diagnoses In Psychiatric Controls and Suicide Atmentioning

confidence: 67%

Association study of two polymorphisms of the serotonin‐2A receptor gene and suicide attempts

Vaquero-Lorenzo

Baca‐García

Díaz-Hernández

et al. 2007

American J of Med Genetics Pt B

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Serotonin (5-HT) receptors may have a role in suicidal behavior. Previous studies have shown an association between the T102C polymorphism of the 5-HT2a receptor gene and suicidal behavior. However, negative findings have also been reported. We examined the association between the T102C and C1354T (His452Tyr) polymorphisms of the 5-HT2a receptor gene and suicide attempts. Four hundred forty-one suicide attempters, 339 psychiatric patients, and 410 healthy controls were compared for genotypes of the T102C and C1354T (His452Tyr) polymorphisms. There were significant differences in the distribution of the three genotypes (TT, TC, and CC) of the T102C polymorphism in the three groups (controls, psychiatric patients, and suicide attempters). There was an excess of C/C genotypes in the suicide attempter group compared with the control group, but there were no significant differences between suicide attempters and psychiatric controls. We found no association between the C1354T polymorphism and suicide attempts. The C allele of the T102C polymorphism of the 5-HT2A receptor gene may be associated with biological susceptibility for suicidal behavior or psychiatric conditions.

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“…Case and control ascertainment and clinical evaluations were standardized between sites as described previously (Baca-Garcia, Oquendo, Saiz-Ruiz, Mann, & de Leon, 2006). Genetic data from subsets of these research participants have been used in previous studies with different research objectives (Almoguera et al, 2011; Almoguera et al, 2013a, 2013b; Alonso et al, 2008; Baca-Garcia et al, 2005; Baca-Garcia et al, 2003; Baca-Garcia, Vaquero, Diaz-Sastre, Garcia-Resa, et al, 2004; Baca-Garcia, Vaquero, Diaz-Sastre, Jimenez-Trevino, et al, 2004; Baca-Garcia et al, 2002; Baca-Garcia et al, 2007; Baca-Garcia et al, 2010; Bermudo-Soriano et al, 2009; Blasco-Fontecilla et al, 2013; Costas et al, 2010; Fernandez-Navarro et al, 2012; Gratacos et al, 2009; Lopez-Castroman et al, 2009; Lorenzo et al, 2007; Penas-Lledo et al, 2012; Perroud et al, 2010; Sublette et al, 2008; Vaquero et al, 2004; Vaquero Lorenzo et al, 2006; Vaquero-Lorenzo et al, 2008; Vaquero-Lorenzo et al, 2014; Vaquero-Lorenzo et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior

Sublette

Vaquero

Baca‐García

et al. 2016

Psychiatric Genetics

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Fatty acid desaturase genes (FADS1-FADS2) encode for desaturases participating in biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs). Since LC-PUFAs are implicated in major depressive disorder (MDD) and suicide risk, and both are partly heritable, we studied the association of FADS1-FADS2 polymorphisms with MDD (635 cases, 480 controls), and suicide attempt status (291 attempters, 338 non-attempters).. Eighteen FADS-related single-nucleotide polymorphisms (SNPs) were genotyped from Caucasians enrolled in Madrid (n=791) or New York City (n=324), and entered as predictors into logistic regression analyses with diagnostic group or suicide attempt history as outcomes, and covariates location and sex. No associations were observed between any SNPs and diagnosis or attempt status. As statistical power was adequate, we conclude that FADS1-FADS2 genetic variants may not be a common determinant of MDD.

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Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia

Cited by 22 publications

References 24 publications

Sequence Variants in <i>BMPR2</i> and Genes Involved in the Serotonin and Nitric Oxide Pathways in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Relation to Clinical Parameters and Comparison with Left Heart Disease

Sequence Variants in <i>BMPR2</i> and Genes Involved in the Serotonin and Nitric Oxide Pathways in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Relation to Clinical Parameters and Comparison with Left Heart Disease

Association study of two polymorphisms of the serotonin‐2A receptor gene and suicide attempts

Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior

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