Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia

Kolovou, Genovefa; Anagnostopoulou, Katherine K.; Kostakou, Peggy; Marvaki, Christina; Mihas, Constantinos; Mikhailidis, Dimitri P.; Cokkinos, Dennis V.

doi:10.1515/cclm.2007.267

Cited by 19 publications

(26 citation statements)

References 42 publications

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“…After oral fat load, the area under the curve (AUC) of the TG, RLP-TG and apoB48 levels is remarkably decreased in homozygous and heterozygous CETP deficient subjects compared with the controls 84 . A common polymorphism in the CETP gene, TaqIB, was also associated with both fasting and postprandial TG levels in heterozygote FH patients 85 . In subjects with abnormal TG response to fat loading, carriers of the B1 allele of the TaqIB polymorphism had higher fasting and postprandial TG compared with B2 allele carriers and a gender related effect was demonstrated 81,86 .…”

Section: Enzymes Of Lipid Metabolismmentioning

confidence: 96%

Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

104

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High levels of fasting circulating triglycerides (TG) represent an independent risk factor for cardiovascular disease. In western countries, however, people spend most time in postprandial conditions, with continuous fluctuation of lipemia due to increased levels of TG-rich lipoproteins (TRLs), including chylomicrons (CM), very low density lipoproteins (VLDL), and their remnants. Several factors contribute to postprandial lipid metabolism, including dietary, physiological, pathological and genetic factors. The presence of coronary heart disease, type 2 diabetes, insulin resistance and obesity is associated with higher postprandial TG levels compared with healthy conditions; this association is present also in subjects with normal fasting TG levels. Increasing evidence indicates that impaired metabolism of postprandial lipoproteins contributes to the pathogenesis of coronary artery disease, suggesting that lifestyle modifications as well as pharmacological approaches aimed at reducing postprandial TG levels might help to decrease the cardiovascular risk.

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Section: Enzymes Of Lipid Metabolismmentioning

confidence: 96%

Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

104

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“…There are also gender differences in the postprandial triglyceride response [30]. While young women have a better response to fatty meals compared with age-matched men [31,32], this advantage is lost after menopause, with a similar response to fatty meals in both genders [33].…”

Section: Gender Differences In Lipidsmentioning

confidence: 99%

Dyslipidemia and Cardiovascular Disease in Women

Cífková

Krajčoviechová

2015

Curr Cardiol Rep

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Cardiovascular disease is the major cause of death in women in developed countries. Dyslipidemia is highly prevalent in women, particularly after the menopause. Elevated low-density lipoprotein cholesterol (LDL-C) has been identified as the key lipid parameter in both genders whereas HDL-cholesterol and triglycerides have been more closely associated, in some studies, with cardiovascular risk in women. Menopause has been shown to be associated with an increase in total and LDL-cholesterol and a decrease in HDL-cholesterol (predominantly in the HDL2 subfraction). Despite its beneficial effects on the lipid profile, hormone replacement therapy is not recommended for primary or secondary prevention of cardiovascular disease in women. The latest meta-analysis of statin trials with gender-specific outcomes showed a similar benefit in women and men. The addition of ezetimibe to simvastatin in patients with acute coronary syndromes showed a further reduction of the primary endpoint in both genders. While there are no gender-related differences in drug treatment of dyslipidemia, current guidelines, to avoid overtreatment, strongly suggest risk estimation before initiating lipid-lowering treatment in women without manifest cardiovascular disease.

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“…17,18 In our study with heterozygotes for familial hypercholesterolemia, the fasting triglyceride values were 71% higher in postmenopausal women compared with premenopausal women. 19 The beneficial effect of endogenous estrogens on plasma S ince the first epidemiological study published nearly 30 years ago, elevated plasma concentration of lipids and lipoproteins are recognized as risk factors for cardiovascular disease (CVD). 1,2 Both aging and menopause are the main causes that lead to an unfavorable lipid profile in women; this in turn results in an enhanced risk of CVD compared with their premenopausal counterparts.…”

Section: Lipid Metabolism and Agingmentioning

confidence: 99%

“…19,21 After menopause, women lose this advantage and have a similar response to a fatty meal compared with agematched men. 16 In contrast, the increased prevalence of elevated cholesterol with age was only found in women.…”

Section: Lipid Metabolism and Agingmentioning

confidence: 99%

Influence of Aging and Menopause on Lipids and Lipoproteins in Women

Kolovou

Bilianou

2008

Angiology

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The actions of endogenous estrogens on the cardiovascular system can be mediated directly on the vessels or indirectly through the modulation of cardiovascular risk factors. Aging and menopause are the main causes that lead to an adverse lipid profile in women. The influence of age on prevalence of increased plasma triglyceride levels and on larger variation in fasting triglyceride levels has been reported in both genders. However, the increased prevalence of increased cholesterol with age was only found in women. The high-density lipid cholesterol level is higher in women than in men throughout all ages. Obesity may also exaggerate the unfavorable lipid profile in aging and/or menopausal women. In the last decades the management of the menopausal women has been a subject of concern for medical scientific groups. In this review, the current understanding of an influence of age and menopause on lipids and lipoproteins concentration in women will be analyzed.

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Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia

Cited by 19 publications

References 42 publications

Postprandial lipemia as a cardiometabolic risk factor

Postprandial lipemia as a cardiometabolic risk factor

Dyslipidemia and Cardiovascular Disease in Women

Influence of Aging and Menopause on Lipids and Lipoproteins in Women

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