Association between the “Timed Up and Go Test” at transplant evaluation and outcomes after kidney transplantation

Michelson, Ariane; Tsapepas, Demetra; Husain, S. Ali; Brennan, Corey; Chiles, Mariana C.; Runge, Brian; Lione, Jennifer; Kil, Byum Hee; Cohen, David J.; Ratner, Lloyd E.; Mohan, Sumit

doi:10.1111/ctr.13410

Cited by 14 publications

(11 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in this present study, failing TUGT was associated with an unfavorable transplant waitlist evaluation outcome (OR 2.14, CI 95% 1.43–3.19, p < .001). The discrepancy from this present study and Michelson et al is likely due to the difference in cutoff time points for TUGT, which are age‐dependent 23,24 . Michelson et al segregated TUGT times as short (<8 s), average (8–9 s), and long >9 (s) and demonstrated a clear association between TUGT time and age.…”

Section: Discussioncontrasting

confidence: 92%

“…TUGT is a validated screening tool for frailty and peri‐operative outcomes that assesses functional mobility, muscle strength, coordination, and physical performance in surgical patients 26–34 . TUGT was previously examined by Michelson et al in renal transplantation patients and was not associated with transplant waitlist removal or post‐transplant outcomes 23 . However, in this present study, failing TUGT was associated with an unfavorable transplant waitlist evaluation outcome (OR 2.14, CI 95% 1.43–3.19, p < .001).…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, Michelson et al evaluated physical performance using the “Timed Up and Go” test (TUGT) on outcomes of patients on the kidney transplant waitlist. However, they demonstrated that TUGT was unable to predict waitlist removal or outcomes after renal transplantation 23 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

Bozhilov

2020

Clinical Transplantation

View full text Add to dashboard Cite

Purpose Frail patients who undergo renal transplantation (RT) have more complications; however, little is known if these patients can sustain the wait to RT. We used the Timed Up and Go Test (TUGT) and Montreal Cognitive Assessment (MoCA) to determine outcomes of RT candidates. Methods In this retrospective study, 526 RT candidates underwent TUGT and MoCA (2015‐2019) and were divided into “favorable” (transplanted or remained on the list) or “unfavorable” (not listed, removed from list, or died) outcome. Demographics, education, language, comorbidities, dialysis type, use of a walking device, TUGT, and MoCA were compared by outcome. Results Overall, 230 patients (43.7%) passed TUG, 268 (51%) passed MoCA, 133 (25.3%) passed both, and 161 (30.6%) failed both tests. Multivariate analysis demonstrated age ≥ 65 (OR 1.58, CI 1.03–2.43), cardiac disease (OR 3.09, CI 2.02–4.72), ≥36 months on dialysis (OR 1.80, CI 1.24–2.69), EPTS < 20% at time of MoCA (OR 0.26, CI 0.07–0.98), and failing TUGT (OR 2.14, CI 1.43–3.19) were associated with unfavorable outcome. Failing MoCA was not associated with outcome. Conclusions MoCA test results were not associated with RT waitlist outcomes; however, passing the TUGT was associated with receiving RT or remaining on the list. Additional studies are needed to validate this and determine outcome after RT.

show abstract

Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

Bozhilov

2020

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…Self-reported functional status, for example, has been found to be associated with post-KT mortality (25). However, other objective measures like the Timed-up-and-go Test was not associated with post-KT length of stay, or early hospital readmission (55). Additionally, lower extremity impairment, objectively measured by the short physical performance battery (SPPB), is present in 48% of KT recipients (56).…”

Section: Alternative Measures Of Vulnerability and Long-term Post-kt mentioning

confidence: 99%

Frailty and Long-Term Post-Kidney Transplant Outcomes

2019

View full text Add to dashboard Cite

Purpose of review: To highlight recent research about frailty and its role as a predictor of adverse, long-term post-kidney transplant (KT) outcomes. Recent findings: Frailty is easily measured using the physical frailty phenotype (PFP) developed by gerontologist Dr. Linda Fried and colleagues. In recent studies, >50% of KT recipients were frail (20%) or intermediately frail (32%) at KT admission. Frail recipients were at 1.3-times higher risk of immunosuppression intolerance and 2.2-times higher risk of mortality, even after accounting for recipient, donor, and transplant factors; these findings were consistent with those on short-term post-KT outcomes. Pilot data suggests that prehabilitation may be an intervention that increases physiologic reserve in frail KT recipients. Summary: The PFP is a effective tool to measure frailty in ESRD that improves risk stratification for short-term and long-term post-KT outcomes. Interventions to improve physiologic reserve and prevent adverse KT outcomes, particularly among frail KT recipients, are needed.

show abstract

“…Nonetheless, there is a compelling case for performing an FP assessment in those screened as at risk of frailty, given the numerous studies that have demonstrated an association between frailty, as identified by the FP, and post-transplant outcomes (28,35). Simpler measures, such as walking speed or the Timed Up and Go Test, do not seem be as good of a predictor of outcomes (44,45). Schaenman et al (46) performed a pilot study evaluating the feasibility and utility of a simple chart review-based Frailty Risk Score (FRS) to predict post-transplant outcomes.…”

Section: How Should Frailty Be Identified In the Potential Kidney Tramentioning

confidence: 99%

Frailty and the Potential Kidney Transplant Recipient: Time for a More Holistic Assessment?

Woywodt

Nixon

2020

Kidney360

View full text Add to dashboard Cite

Association between the “Timed Up and Go Test” at transplant evaluation and outcomes after kidney transplantation

Abstract: The TUGT was not associated with waitlist removal or prolonged hospitalization for kidney transplant candidates. Alternative assessments of global health, such as functional status or frailty, should be considered for evaluation of potential kidney transplant candidates.

Cited by 14 publications

References 32 publications

Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

Can the Timed Up & Go Test and Montreal Cognitive Assessment predict outcomes in patients waitlisted for renal transplant?

Frailty and Long-Term Post-Kidney Transplant Outcomes

Frailty and the Potential Kidney Transplant Recipient: Time for a More Holistic Assessment?

Contact Info

Product

Resources

About