Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke

Abstract

The aim of this study is to evaluate the value of the triglyceride-glucose (TyG) index and the risk of large artery atherosclerotic (LAA) stroke. Information on general demographic and clinical characteristics, magnetic resonance angiography (MRA) examination, and blood biochemical index determination were obtained. Based on age stratification, three models to evaluate the odds ratio (OR) and the 95% confidence interval (95% CI) were employed to determine the correlation between the TyG index and the risk of LAA stroke. The most effective TyG index threshold in predicting a high risk of LAA stroke was identified using receiver operating characteristic (ROC) curve analysis. Logistic regression verified the association between the risk of LAA stroke and the TyG index. Both with and without age stratification, logistic regression analysis showed that the TyG index was a significant predictor of the occurrence of LAA stroke ( P < 0.05 ). The maximum Youden index for determining a high risk of LAA stroke was found at a TyG index of 4.60. The area under the ROC curve was 0.69 (95% CI: 0.646–0.742, P < 0.05 ), sensitivity was 78.0%, and specificity was 63.4%. An elevated TyG index was remarkably associated with a high risk of LAA stroke.

Triglyceride-glucose index as a biomarker to differentiate stroke subtypes: A hospital-based cross-sectional study

“…Zhang et al reported that the TyG index is correlated with SVD and may have the potential to optimize the risk stratification of SVD 13, 14 . Furthermore, the TyG index was reported to be a useful biomarker of LAA stroke and can help in identifying candidates for carotid reperfusion 15 . A recent study demonstrated that the TyG index is a significant risk factor for intracranial stenosis and has a linear association with the number and degree of vessel stenosis 16 .…”

Update on Biomarkers Associated with Large Artery Atherosclerosis Stroke

“…Age, hypertension and the triglyceride-glucose index were identified as predictors of LAA stroke, with a positive correlation between the triglyceride-glucose index and LAA stroke incidence, even after adjusting for related risk factors. While the retrospective design of the study prevents further conclusions, the authors hypothesize that the high triglycerideglucose index might have contributed to the development of unstable atherosclerotic plaques by affecting inflammatory active substances, and subsequently led to clinical events [14].…”

Update on Biomarkers Associated with Large-Artery Atherosclerosis Stroke

“…Triglyceride levels were also studied by Jiang et al, who looked at insulin resistance and its marker triglyceride-glucose index [ 14 ]. This retrospective cross-sectional study looked at 2836 patients admitted to the Ma’anshan People’s Hospital due to acute IS, again divided between an LAA stroke group ( n = 458) and a non-LAA stroke group ( n = 2378).…”

“…Age, hypertension and the triglyceride-glucose index were identified as predictors of LAA stroke, with a positive correlation between the triglyceride-glucose index and LAA stroke incidence, even after adjusting for related risk factors. While the retrospective design of the study prevents further conclusions, the authors hypothesize that the high triglyceride-glucose index might have contributed to the development of unstable atherosclerotic plaques by affecting inflammatory active substances, and subsequently led to clinical events [ 14 ].…”