Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study

Compañ-Gabucio, Laura; Torres-Collado, Laura; García‐de‐la‐Hera, Manuela; Fernández-Somoano, Ana; Tardón, Adonina; Júlvez, Jordi; Sunyer, Jordi; Rebagliato, Marisa; Murcia, Mario; Ibarluzea, Jesús; Santa‐Marina, Loreto; Vioque, Jesús

doi:10.3390/ijerph191912123

Cited by 7 publications

(3 citation statements)

References 72 publications

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“…There have been several studies investigating the sex-specific effects of prenatal folic acid supplement on offspring’s health outcomes. For example, a Spanish multicenter longitudinal study reported that low (<400 μg/day) folic acid supplements use during pregnancy was associated with poorer attentional function in girls and poorer working memory in boys, and high (≥1000 μg/day) folic acid supplement was associated with a better working memory only in girls [ 67 ]. Moreover, the effects of prenatal folic acid supplementation on body weight and insulin resistance were sex-dependent in a rat experiment, which showed that maternal folic acid supplementation could increase body weight and insulin sensitivity in male offspring, but decrease body weight and increase insulin sensitivity in female offspring [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Joint Effects of Prenatal Folic Acid Supplement with Prenatal Multivitamin and Iron Supplement on Obesity in Preschoolers Born SGA: Sex Specific Difference

Strodl

Yang

et al. 2023

Nutrients

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Prenatal maternal nutrient supplementation has been reported to be associated with offspring obesity, but the reports are inconsistent and have mainly ignored the differences between the total children population and children born small for gestational age (SGA). This study aimed to examine the joint effects of folic acid, iron, and multivitamin supplementation during pregnancy on the risk of obesity in preschoolers born SGA. A total of 8918 children aged 3–6.5 years born SGA were recruited from Longhua District in Shenzhen of China in 2021. Their mothers completed a structured questionnaire about the child’s and parents’ socio-demographic characteristics, maternal prepregnant obesity, and mothers’ prenatal supplementation of folic acid, iron, and multivitamin. In addition, the children’s current weight and height were measured by trained nurses. Logistic regression models were used to analyze the associations between prenatal supplementations and the current presence of childhood obesity. After controlling for potential confounders, the results of the logistic regression analysis showed that prenatal supplement of folic acid (OR = 0.72, 95% CI = 0.55~0.93) was associated with a lower likelihood of being an obese preschooler born SGA. In contrast, the ingestion of multivitamin or iron supplements during pregnancy did not seem to be related to the likelihood of childhood obesity in preschoolers born SGA. Moreover, cross-over analysis of prenatal folic acid and multivitamin obtained significant negative associations of prenatal folic acid supplement only (OR = 0.73, 95% CI = 0.55~0.97) and combination supplement of folic acid and multivitamin (OR = 0.67, 95% CI = 0.50~0.90) with obesity of preschoolers born SGA; while the cross-over analysis of prenatal folic acid and iron observed significant negative associations between obesity of preschoolers born SGA and a combination supplement of folic acid and iron (OR = 0.70, 95% CI = 0.52~0.96). Furthermore, the aforementioned significant associations were only found in girls and not in boys when the analyses were stratified by sex. Our findings suggest that the prenatal folic acid supplementation may decrease the risk of obesity in preschool girls born SGA, and that this effect may be modified by prenatal multivitamin or iron supplementation.

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Section: Discussionmentioning

confidence: 99%

Joint Effects of Prenatal Folic Acid Supplement with Prenatal Multivitamin and Iron Supplement on Obesity in Preschoolers Born SGA: Sex Specific Difference

Strodl

Yang

et al. 2023

Nutrients

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“…Interestingly, they also observed comparatively better cognitive and working memory among girls [61]. Another study conducted in Japan reports a higher cognitive, language, and social development quotient among 4-years-olds whose mothers began FA supplementation before week 12 of gestation [8].…”

Section: Early Childhood Cognitionmentioning

confidence: 91%

Advances in Folic Acid Biosensors and Their Significance in Maternal, Perinatal, and Paediatric Preventive Medicine

Movendane,

Sipalo,

Chan

2023

Biosensors

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Auxotrophic primates like human beings rely on exogenous dietary vitamin B9 supplementation to meet their metabolic demands. Folates play a crucial role in nucleotide synthesis and DNA methylation. Maternal folate deficiency causes several pregnancy-related complications, perinatal defects, and early childhood cognitive impairments. New evidence suggests excess FA is a potential risk factor resulting in unfavourable genomic and epigenomic alterations. Thus, it is essential to revisit the need to consistently monitor maternal folate levels during pregnancy. Yet, to date, no point-of-care folate-monitoring biosensor is commercially available. Here, we critically appraise the advances in folate biosensors to understand the translational gaps in biosensor design. Further, our review sheds light on the potential role of folate biosensors in strengthening maternal, perinatal, and child healthcare.

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“…Moreover, periconceptional use of FA folic acid supplements < 0.4 mg/day or ≥ 1 mg/day has been shown to produce deficits in attentional function only in boys aged 4 -5 years [28]. Longterm follow-up (7 -9 years) of children born to mothers who used folic acid supplements beyond the periconceptional period identified deficits in attentional function different for boys and girls [29]. In contrast, the results of the 2006/2007 randomized controlled trial of 0.4 mg/day folic acid supplementation during the second and third trimesters (FASSTT) from the 14 th week of gestation to the end of pregnancy, showed at 7 years beneficial effects regarding children's cognitive performance [30].…”

Section: Drugs Administration In Pregnancy and Asd Riskmentioning

confidence: 99%

Untitled

2023

FARMACIA

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The prescription of drugs for the treatment of infertility or during pregnancy has seen a sharp increase in recent years. The study aimed to review the main drugs used to evaluate the balance of benefits/risks of preconception during infertility treatment or during pregnancy. A 10-year PubMed database was searched to assess the association between medication use and offspring health outcomes. Careful analysis of pharmacovigilance reports regarding the potential risk of certain classes of drugs administered during infertility treatments or during pregnancy and ASD is the main strategy regarding the appropriate neurodevelopment of the offspring. RezumatPrescrierea de medicamente pentru tratamentul infertilității sau în timpul sarcinii a cunoscut o creștere bruscă în ultimii ani. Studiul și-a propus să sumarizeze principalele medicamente utilizate pentru evaluarea echilibrului beneficii/riscuri ale preconcepției în timpul tratamentului pentru infertilitate sau în timpul sarcinii. Baza de date PubMed, pe o perioadă anterioară de 10 ani, a fost investigată pentru a evalua asocierea dintre utilizarea medicamentelor și rezultatele sănătății descendenților. Analiza atentă a rapoartelor de farmacovigilență cu privire la riscul potențial al anumitor clase de medicamente administrate în timpul tratamentelor pentru infertilitate sau în timpul sarcinii și al tulburării din sfera autismului (TSA) este strategia principală în ceea ce privește neurodezvoltarea adecvată a descendenților.

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Association between the Use of Folic Acid Supplements during Pregnancy and Children’s Cognitive Function at 7–9 Years of Age in the INMA Cohort Study

Cited by 7 publications

References 72 publications

Joint Effects of Prenatal Folic Acid Supplement with Prenatal Multivitamin and Iron Supplement on Obesity in Preschoolers Born SGA: Sex Specific Difference

Joint Effects of Prenatal Folic Acid Supplement with Prenatal Multivitamin and Iron Supplement on Obesity in Preschoolers Born SGA: Sex Specific Difference

Advances in Folic Acid Biosensors and Their Significance in Maternal, Perinatal, and Paediatric Preventive Medicine

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