Association between the WRAP53 gene rs2287499 C&gt;G polymorphism and cancer risk: A meta-analysis

Cao, Hanyu; Wang, Shaopu; Zhang, Z Y; Lou, Jiangyan

doi:10.4238/gmr.15037976

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…In this context, the common nonsynonymous SNP in codon 68 of the first coding exon of Wrap53 (rs2287499 c.202C>G) results in the amino acid change arginine (Arg 68 ) to glycine (Gly 68 ), which might affect protein function (33). In particular, the Wrap53 C>G SNP has been associated with primary tumor risk (33)(34)(35)(36)(37). However, the impact of this SNP on stroke remains unexplored.…”

Section: Wrap53 Rs2287499 C>g Snp Regulates Protein Nuclear Transloca...mentioning

confidence: 99%

“…Inclusion criteria were patients admitted within the first 12 hours after the onset of symptoms (or from the start of sleep in those with symptoms upon awakening) who were previously independent for daily living activities. Patients receiving tissue reperfusion therapies (65), those included in clinical trials (33), and those showing severe systemic disease (28) were excluded. In addition, some patients (24) refused to participate in the study, and others (36) were lost during the follow-up.…”

Section: Patientsmentioning

confidence: 99%

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Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke

et al. 2020

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Failure of neurons to efficiently repair DNA double-strand breaks (DSBs) contributes to cerebral damage after stroke. However, the molecular machinery that regulates DNA repair in this neurological disorder is unknown. Here, we found that DSBs in oxygen/glucose-deprived (OGD) neurons spatiotemporally correlated with the up-regulation of WRAP53 (WD40-encoding p53-antisense RNA), which translocated to the nucleus to activate the DSB repair response. Mechanistically, OGD triggered a burst in reactive oxygen species that induced both DSBs and translocation of WRAP53 to the nucleus to promote DNA repair, a pathway that was confirmed in an in vivo mouse model of stroke. Noticeably, nuclear translocation of WRAP53 occurred faster in OGD neurons expressing the Wrap53 human nonsynonymous single-nucleotide polymorphism (SNP) rs2287499 (c.202C>G). Patients carrying this SNP showed less infarct volume and better functional outcome after stroke. These results indicate that WRAP53 fosters DNA repair and neuronal survival to promote functional recovery after stroke.

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Section: Wrap53 Rs2287499 C>g Snp Regulates Protein Nuclear Transloca...mentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke

et al. 2020

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“…In addition, Hube et al reported that alternative splicing of SRA1 could lead to the generation of coding and non-coding RNA isoforms in breast cancer cell lines [ 37 ]. Cao et al recently reported about the association between the WRAP53 gene rs2287499 C > G polymorphism and cancer risk [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

ncRNA-disease association prediction based on sequence information and tripartite network

et al. 2018

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BackgroundCurrent technology has demonstrated that mutation and deregulation of non-coding RNAs (ncRNAs) are associated with diverse human diseases and important biological processes. Therefore, developing a novel computational method for predicting potential ncRNA-disease associations could benefit pathologists in understanding the correlation between ncRNAs and disease diagnosis, treatment, and prevention. However, only a few studies have investigated these associations in pathogenesis.ResultsThis study utilizes a disease-target-ncRNA tripartite network, and computes prediction scores between each disease-ncRNA pair by integrating biological information derived from pairwise similarity based upon sequence expressions with weights obtained from a multi-layer resource allocation technique. Our proposed algorithm was evaluated based on a 5-fold-cross-validation with optimal kernel parameter tuning. In addition, we achieved an average AUC that varies from 0.75 without link cut to 0.57 with link cut methods, which outperforms a previous method using the same evaluation methodology. Furthermore, the algorithm predicted 23 ncRNA-disease associations supported by other independent biological experimental studies.ConclusionsTaken together, these results demonstrate the capability and accuracy of predicting further biological significant associations between ncRNAs and diseases and highlight the importance of adding biological sequence information to enhance predictions.

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“…Single Nucleotide Polymorphisms (SNPs) may alter gene regulation and structure and result in aberrant RNA or protein dysfunction. Although cancer-associated SNPs in determinant genes can increase the risk of cancer, as shown already for TP53 and WRAP53 in breast cancer susceptibility [18,19,20], it is necessary to define haplotype blocks to investigate the role of neighboring SNPs in cancer risk and calculate the linkage disequilibrium (LD) [21]. LD is the association between two nearby markers (e.g., SNPs), that result from common inheritance and are influenced by population size and mutation age.…”

Section: Introductionmentioning

confidence: 99%

Haplotype and linkage disequilibrium of TP53-WRAP53 locus in Iranian-Azeri women with breast cancer

et al. 2019

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Among the cancer susceptibility genes, TP53 is one of the crucial genes involved in cell cycle regulations and, therefore, it greatly affects breast cancer initiation and progression. In addition, WRAP53 —a natural antisense transcript—regulates TP53 transcription and, as a protein, modulates the normal cell cycle, which results in breast cancer susceptibility. In this study, we aimed to analyze a haplotype comprising four SNPs, including rs1042522, rs17878362, rs2287499, and rs2287498, which are located at 5′ regions of the TP53 and WRAP53 genes, in 118 patients and 110 healthy controls of the Iranian-Azeri population. In silico studies were conducted using the SIFT, Polyphen2, Fanthmm, RNAsnp, and SNP&GO online servers. Linkage disequilibrium (LD) and D′ for each combination of the markers were calculated via the Haploview program. Our results showed that the GA 1 CC haplotype was the most frequent in the studied population. Additionally, no significant LD between any pairwise haplotypes was observed. The GA 1 CC and CA 2 GC haplotypes were significantly associated with breast cancer susceptibility. Moreover, the in silico analysis revealed the negative effects of rs2287499 and rs1042522 on WRAP53 and P53, respectively. In conclusion, the CA 1 GC haplotype was strongly identified as a breast cancer risk factor, and the GA 1 CC haplotype was assumed to be a protective factor against breast cancer risk. Hence, these markers may potentially be used as molecular prognostic and predictive biomarkers for breast cancer.

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Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis

Cited by 5 publications

References 27 publications

Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke

Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke

ncRNA-disease association prediction based on sequence information and tripartite network

Haplotype and linkage disequilibrium of TP53-WRAP53 locus in Iranian-Azeri women with breast cancer

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