Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis

Dy, Liu; Hc, Liang; Xm, Xiao

doi:10.4238/2015.august.19.15

Cited by 7 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A latest meta-analysis exploring the association between the Arg399Gln polymorphism and cervical cancer showed that the Arg399Gln polymorphism increased the risk of cervical cancer [27]. The result contradicted ours and the reasons may include the following.…”

Section: Discussionmentioning

confidence: 68%

Association between XRCC1 polymorphisms and the risk of cervical cancer: a meta-analysis based on 4895 subjects

et al. 2016

View full text Add to dashboard Cite

The present meta-analysis was intended to explore the relationship between the X-ray repair cross complementing 1 (XRCC1) polymorphisms (Arg194Trp, Arg280His and Arg399Gln) and cervical cancer risk. Several electronic databases were searched systematically and bibliographies of relevant papers were identified carefully. Then, a meta-analysis was performed based on eligible studies in various genetic models. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were employed to evaluate the strength of associations between the XRCC1 polymorphisms and cervical cancer risk. Additionally, heterogeneity analysis and sensitivity analysis were done if necessary. Totally, 11 articles involving 2092 cases and 2803 controls were included. Taken together, there was no obvious association between the Arg194Trp or Arg280His polymorphism and cervical cancer risk. Considering the great heterogeneity, subgroup analysis was done, but the pooled result remained stable. Nevertheless, the association between the Arg399Gln polymorphism and cervical cancer risk showed distinct statistic significance in the allele model, dominant model, homozygous model and heterozygous model. In view of the exiting heterogeneity, we did subgroup analysis stratified by ethnicity, resulting in the fact that the Arg399Gln polymorphism was related to the decreased risk of cervical cancer. The Begg's test and Egger's test were used to find no publication bias. To conclude, the current meta-analysis indicated that the XRCC1 Arg399Gln polymorphism decreased the risk of cervical cancer, while the Arg194Trp and Arg280His polymorphisms were not associated with cervical caner risk. Certainly, a well-designed large-scale multicenter study is warranted to confirm the finding.

show abstract

Section: Discussionmentioning

confidence: 68%

Association between XRCC1 polymorphisms and the risk of cervical cancer: a meta-analysis based on 4895 subjects

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A comprehensive meta-analysis of 10 case-control studies gathering 2051 CC cases and 2919 control subjects showed a significant association with no ethnic differences between white and Asian populations. 37 These findings were further confirmed in Chinese population where a significantly elevated risk was observed. 38 Our results are in agreement with these findings and provide independent confirmation cohort in our population.…”

Section: Discussionmentioning

confidence: 63%

Genetic Predisposition to Cervical Cancer and the Association With XRCC1 and TGFB1 Polymorphisms

Al-Harbi

Judia

Mishra

et al. 2017

Int J Gynecol Cancer

View full text Add to dashboard Cite

TGFB1 T10C and XRCC1 G399A SNPs were associated with CC risk in univariate and multivariate analysis and displayed allele-dosage effects and coselection in cancer patients. Patients harboring the majority allele TGFB1 T10 (Leu) or the variant allele XRCC1 399A (Gln) have approximately 1.5-fold increased risk to develop CC. Host SNPs genotyping may provide relevant biomarkers for CC risk assessment in personalized preventive medicine.

show abstract

“…24,25 However, little published information is available regarding the association between polymorphism of XRCC1, XRCC2 and XRCC3 gene and susceptibility to cervical carcinoma. 26 Also, few studies from Northern and Southern India have reported the genetic polymorphisms in the DNA repair genes with respect to a variety of cancer risks including prostate, breast, oral and esophageal cancers, but only couple of studies available to reveal the association of polymorphisms in XRCC1, XRCC2 and XRCC3 genes with CC development and the results were with incompatible conclusions. 27,28 Some recent studies discovered positive association of Arg194Trp variant of XRCC1 with CC development risk while other demonstrated a strong association of the Arg399Gln polymorphism with an increased risk of CC, but other failed to find the significant result.…”

Section: Discussionmentioning

confidence: 99%

Assessment of role of genetic polymorphisms in XRCC1, XRCC2 and XRCC3 genes in cervical cancer susceptibility from a rural population: a hospital based case-control study from Maharashtra, India

et al. 2018

View full text Add to dashboard Cite

Background: Cervical cancer is a major concern of health risk, moreover the leading cause of cancer causing deaths in women of rural parts of India. This study was aimed to assess the risk of cervical cancer development in association with polymorphisms in X-Ray Cross Complementing Group (XRCC1, XRCC2 and XRCC3) genes in the rural population of south-western Maharashtra. We focused to determine the frequency of polymorphisms in DNA repair genes including XRCC1 at codon (cd) 194, cd 280, cd 399, XRCC2 at cd 188 and XRCC3 at cd 241 and their plausible role in cervical cancer risk from rural parts of India.Methods: This study included 350 proven cases with cervical cancer and 400 age and sex matched controls. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze the association XRCC1, XRCC2 and XRCC3 gene polymorphisms with cervical cancer development in women of South-Western Maharashtra.Results: The result from our study showed that allele frequencies of selected genes were not statistically different between the groups for XRCC1 Trp194, XRCC2 His188 and XRCC3 Met241. XRCC1 His280 (OR= 4.36; 95% CI= (3.20-5.95); p= <0.0001) and XRCC1 Gln399 (OR= 2.99; 95% CI= (1.60-5.56); p= <0.0001) genotypes significantly increased the risk of cervical cancer.Conclusions: This study indicates that polymorphisms in cd 280 of exon 9 and cd 399 of exon 10 of XRCC1 gene could play a role in modifying genetic susceptibility of individuals towards cervical cancer among women from rural Maharashtra. This case-control study suggest that selected DNA repair genes represent genetic determinants in cervical carcinogenesis along with other risk factors in the rural Indian population.

show abstract

Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis

Cited by 7 publications

References 15 publications

Association between XRCC1 polymorphisms and the risk of cervical cancer: a meta-analysis based on 4895 subjects

Association between XRCC1 polymorphisms and the risk of cervical cancer: a meta-analysis based on 4895 subjects

Genetic Predisposition to Cervical Cancer and the Association With XRCC1 and TGFB1 Polymorphisms

Assessment of role of genetic polymorphisms in XRCC1, XRCC2 and XRCC3 genes in cervical cancer susceptibility from a rural population: a hospital based case-control study from Maharashtra, India

Contact Info

Product

Resources

About