Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function

Jung, Kyong Yeun; Ahn, Hwa Young; Han, Sun Kyoung; Park, Young Joo; Cho, Bo Youn; Moon, Min Kyong

doi:10.1016/j.jacl.2017.08.015

Cited by 66 publications

(72 citation statements)

References 36 publications

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“…Indeed, a higher prevalence of larger HDL 2 subclasses was found in subjects with hypothyroidism in a study by Tan et al (76). Larger HDL particles are generally considered as highly atheroprotective, but, as it has been already mentioned, novel data (75) suggest that functionality of HDL particles in hypothyroidism is compromised.…”

Section: Hashimoto Thyroiditis and Dyslipidemiamentioning

confidence: 93%

“…Most of the known data regarding the beneficial effects of L-T4 treatment on lipid profile is derived from studies in adults with overt or subclinical hypothyroidism (12,75,(97)(98)(99)(100)(101)(102). Among the recent studies, Minarikova et al demonstrated significant improvements of total cholesterol (TC), LDL-C, TG, apoB, atherogenic index of plasma, and LDL subclasses following L-T4 substitution treatment in 40 newly-diagnosed overt hypothyroidism patients with AIT (103).…”

Section: Effects Of L-thyroxine Treatment On Lipid Status In Hashimotmentioning

confidence: 99%

“…Among the recent studies, Minarikova et al demonstrated significant improvements of total cholesterol (TC), LDL-C, TG, apoB, atherogenic index of plasma, and LDL subclasses following L-T4 substitution treatment in 40 newly-diagnosed overt hypothyroidism patients with AIT (103). Uniquely designed study of 27 adult patients who underwent total thyroidectomy and radioactive iodine treatment for differentiated thyroid carcinoma, revealed that dynamic changes in thyroid function are associated with corresponding dynamic changes of the lipid profile and HDL function (75). Compared to the baseline levels (on L-T4 treatment), when patients entered the overt hypothyroid state (TSH > 30 mU/L after 4 weeks of L-T4 withdrawal), the levels of TC, TG, LDL-C, apoA-I, and apoB significantly increased, and then again recovered to the baseline levels after 3 months, following the reinstitution of L-T4 treatment.…”

Section: Effects Of L-thyroxine Treatment On Lipid Status In Hashimotmentioning

confidence: 99%

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Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review

et al. 2019

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Hashimoto autoimmune thyroiditis (AIT) is the most common cause of acquired hypothyroidism in the pediatric population. Development of AIT is mediated mainly by cellular immune response directed toward thyroid autoantigens, leading to inflammation and impaired function of thyroid gland. Both thyroid dysfunction and inflammation affect the metabolism of plasma lipoproteins. The alterations in lipid profile worsen with the advancement of hypothyroidism, ranging from discrete changes in euthyroid AIT patients, to atherogenic dyslipidemia in the overt hypothyroidism. In this review, characteristics of dyslipidemia in pediatric AIT patients, and the consequences in respect to the risk for cardiovascular disease (CVD) development are discussed. Additionally, benefit of L-thyroxine treatment on serum lipid profile in pediatric AIT patients is addressed. Finally, potential usefulness of novel lipid biomarkers, such as proprotein convertase subtilisin/kexin type 9 (PCSK9), non-cholesterol sterols, low-density lipoprotein particle size and number, and high-density lipoprotein structure and functionality in AIT patients is also covered. Further longitudinal studies are needed in order to elucidate the long-term cardiovascular outcomes of dyslipidemia in pediatric patients with Hashimoto AIT.

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Section: Hashimoto Thyroiditis and Dyslipidemiamentioning

confidence: 93%

Section: Effects Of L-thyroxine Treatment On Lipid Status In Hashimotmentioning

confidence: 99%

Section: Effects Of L-thyroxine Treatment On Lipid Status In Hashimotmentioning

confidence: 99%

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Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review

et al. 2019

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“…The opposite occurs when there is a hypofunctioning of thyroid hormones as is the case with SCH. Several studies have demonstrated an increase in total cholesterol (TC), triglycerides (TGs), LDL‐C, HDL‐C and LDL/HDL ratio as well as apoB levels 21‐23 . In SCH, the lipoprotein lipase activity in the adipose tissue and the hepatic lipase activity are both decreased leading to increased levels of TGs.…”

Section: Cardiometabolic Effects Of Subclinical Hypothyroidismmentioning

confidence: 99%

“…The thyroid hormones exert their effects through their receptors α and β located in the myocardial and vascular endothelial tissues and modulate their cardiovascular function 6‐8 . Minor changes in thyroid hormone levels could have an adverse impact on the cardiometabolic effects in the body that include increases in serum cholesterol and glucose levels, endothelial dysfunction through decreased availability of nitric oxide (NO), causing arterial stiffness and increase in peripheral vascular resistance and blood pressure (BP), all being significant risk factors for CVD and HF 9‐13 . However, there is currently a debate in the literature regarding the adverse cardiometabolic effects of SCH and its treatment 14‐16 .…”

Section: Introductionmentioning

confidence: 99%

The current debate over treatment of subclinical hypothyroidism to prevent cardiovascular complications

Chrysant

2020

Int J Clin Pract

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Background Subclinical hypothyroidism (SCH) is an asymptomatic condition associated with increased thyroid‐stimulating hormone (TSH) >4 mIU/L with normal thyroxine (T4) and triidothyronine (T3) levels. It is more common in older subjects and especially in women with an overall incidence of 10%. Objective Because the normal TSH levels increase with age up to 7.5 mIU/L in older people, several studies have reported either no benefits whereas others have reported the benefits of treatment. These studies have caused a great debate over the treatment of SCH, especially in older subjects. Therefore, the objective of this study was to review the current evidence over this debate by reviewing the recent literature on the subject to discern whether treatment of SCH is necessary and under what circumstances. Methods To get a better perspective on the current debate over treatment of SCH, a focused Medline search of the English language literature was conducted from 2012 to 2019 using the terms, hypothyroidism, subclinical, dyslipidaemia, cardiovascular disease, heart failure and 38 papers with pertinent information were selected. Results The analysis of results from these papers indicated that the normal levels of TSH are increasing with the advancement of age from 4 mIU/L up to 7.5 mIU/L for patients ≥75 years of age. Also, several of reviewed studies have shown no benefits of treatment whereas, others have shown definite benefits of treatment with levothyroxine supplementation on the clinical and metabolic effects of SBH with reductions in CVD, HF and mortality. The treatment is more effective in younger persons and less so in older persons. Conclusions Based on the overall evidence, treatment of SCH is indicated in younger persons with a TSH level >4.0 mIU/L. In older subjects, treatment should be individualised and based on the presence of symptoms, the level of TSH, and initiated at TSH levels ≥10 mIU/L and at low doses to avoid adverse cardiovascular effects from overtreatment.

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Expressions of glycemic parameters, lipid profile, and thyroid hormone in patients with type 2 diabetes mellitus and their correlation

Chen,

Wu,

Lyu

2024

Immunity Inflam & Disease

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ObjectiveThis study aimed to investigate the expressions of glycemic parameters, lipid profile, and thyroid hormone in type 2 diabetes mellitus (T2DM) patients and their correlation.MethodsEighty‐four patients with T2DM in our hospital were included as the observation group. The T2DM patients were divided into mild group, moderate group, and severe group according to the fasting plasma glucose (FPG) level. Another 84 healthy subjects in the same period of health examination in our hospital were included as the control group. The levels of glycemic parameters, (HbA1c and FPG), lipid profile (TC, TG, LDL‐C, and HDL‐C) and thyroid hormone (FT3, TSH, and FT4) were measured by automatic biochemical analyzer. The correlation between glycemic parameters, lipid profile, and thyroid hormone was analyzed by Pearson correlation analysis.ResultsThe FPG, TC, TG, LDL‐C, HbA1c, and TSH levels were significantly elevated, while the HDL‐C and FT3 levels were significantly declined in the observation group versus to control group (p < .05). The levels of HbA1c, FPG, TC, LDL‐C, and TSH were significantly increased, while the levels of HDL‐C and FT3 were decreased in moderate and severe groups, when compared to mild group (p < .05). The levels of HbA1c, FPG, TC, LDL‐C and TSH were higher, while the level of FT3 was lower in severe group than those in moderate group (p < .05). Pearson Correlation analysis showed that FT3 level in T2DM patients was positively correlated with FPG, HbAlc, TC, TG, and LDL‐C levels (p < .05), but negatively correlated with HDL‐C level (p < .05). TSH level was negatively correlated with FPG, HbAlc, TC, TG, and LDL‐C levels (p < .05), while positively correlated with HDL‐C level.ConclusionThe thyroid hormone levels were of clinical significance in evaluating glycolipid metabolism and severity of T2DM. Clinical detection of glycolipid metabolism and thyroid hormone levels in T2DM patients is of great significance for diagnosis, evaluation, and targeted treatment of the disease.

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Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function

Cited by 66 publications

References 36 publications

Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review

Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review

The current debate over treatment of subclinical hypothyroidism to prevent cardiovascular complications

Expressions of glycemic parameters, lipid profile, and thyroid hormone in patients with type 2 diabetes mellitus and their correlation

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