Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: A systematic review and meta-analysis

Yang, Jong Pill; Hyun, Myung Han; Yoon, Jeong Min; Park, Min Jeong; Kim, Donghyeok

doi:10.1016/j.cyto.2014.07.005

Cited by 33 publications

(33 citation statements)

References 63 publications

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“…Earlier meta-analyses by two different group also reported similar observations in the year 2014 (46,49). In addition, several reports including only Caucasian ethnic group for analysis demonstrated a possible association with GC susceptibility, further strengthening our observations (50)(51)(52).…”

Section: Discussionsupporting

confidence: 76%

“…Our present meta-analysis has several advantages over previous reports. The most recent meta-analyses were reported in the year 2014 (46,49,51). In the present study, five recent case-control studies investigating the role of TNF-α -308G>A in GC susceptibility were included, leading to an analysis including a much larger number of cases (n=8353) and controls (n=12099) (13,14,16,28,29).…”

Section: Discussionmentioning

confidence: 99%

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Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: A case control study and meta-analysis

Du¹,

Gao²

2017

Turk J Gastroenterol

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Background/Aims: In the Chinese population, gastric cancer (GC) is ranked as the third most common type of cancer. Although the exact etiology of GC development is unclear, several factors, including genetic and environmental, have been identified as risk factors. Variations in cytokine genes and their receptors have been related to a higher risk of GC. A single nucleotide polymorphism in the promoter region of tumor necrosis factor-α (TNF-α) (-308G>A) has been associated with a higher risk of GC and in the present study we evaluated its possible association with GC in a Chinese cohort. In addition, we performed a meta-analysis to draw a firm conclusion about the association between TNF-α gene polymorphisms and GC. Materials and Methods: We enrolled 400 Chinese GC patients and matched healthy controls hailing from similar geographical areas. The TNF-α -308G/A polymorphism was genotyped by allele-specific polymerase chain reaction (AS-PCR). For the meta-analysis, earlier published articles were searched and eligible studies were included. Results: Prevalence of the heterozygous mutant (GA) and minor allele (A) were significantly higher in GC cases compared to healthy controls (GA: p<0.0001, odds ratio (OR)=4.90; A: p<0.0001, OR=2.84). A total of 36 eligible studies including the present report, encompassing of 8353 GC patients and 12099 controls, were analyzed for the meta-analysis. A significant association of the TNF-α polymorphism (-308G>A) with susceptibility to GC was only found in the Caucasian population (A vs G: p=0.001; AA vs GG: p=0.01; AG vs GG: p<0.0001; AA vs AG+GG: p=0.01; AA+AG vs p=0.003). Conclusion:The results of the present case control study and meta-analysis showed that associations between TNF-a variants with susceptibility to GC development is population and ethnic specific. Keywords: Gene polymorphism, TNF-α, gastric cancer, meta-analysis, association, Chinese Original ArticleCite this article as: Du LC, Gao R. Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: a case control study and metaanalysis. Turk J Gastroenterol 2017; 28: 272-82.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: A case control study and meta-analysis

Du¹,

Gao²

2017

Turk J Gastroenterol

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“…The overall frequency of TNF-␣-308 A allele was 25.7% in Chinese Han population in Henan province, which was lower than that in Indian population [23] and higher than that in Spanish population [24]. Many studies suggest that there is an obvious association between TNF-␣-308 polymorphism and gastric cancer risk, especially in Caucasians [25,26], but for other ethnic populations the results remain inconclusive [21,27,28]. The discrepancy between our results and other studies may be explained by the different heterogeneous genetic background in different ethnics or different sample size.…”

Section: Discussionmentioning

confidence: 93%

TNF-α-308/-238 polymorphisms are associated with gastric cancer: A case-control family study in China

Cao

Jiang

et al. 2017

Clinics and Research in Hepatology and Gastroenterology

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“…[60] There were 28 out of 44 studies using PCR-RFLP and 16 studies using other methods such as PCR-SSCP, MS, and TaqMan. Similarly to the total population, significant association between TNF-α −308G/A gene polymorphism and IHD risk was observed in the PCR-RFLP studies rather than the non-RFLP studies, suggesting that PCR-RFLP might be a good choice for genotyping method in DNA polymorphism analysis.…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor-alpha gene polymorphisms and susceptibility to ischemic heart disease

Zhang

et al. 2017

Medicine

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Background: A number of studies had reported the association between tumor necrosis factor-alpha (TNF-a) gene polymorphisms and ischemic heart disease (IHD) risk. However, the results remained controversial. Therefore, we performed a systematic review with multiple meta-analyses to provide the more precise estimations of the relationship.Methods: We systematically searched electronic databases (PubMed, the Web of Science, EMBASE, Medline, Chinese National Knowledge Infrastructure, WanFang and ChongQing VIP Database) for relevant studies published up to February 2017. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for assessing the association. The present meta-analysis was performed using STATA 12.0 software.Results: In total, 45 articles with 17,375 cases and 15,375 controls involved were included. Pooled ORs revealed a significant association between TNF-a À308G/A gene polymorphism and IHD (A vs. G: OR = 1.22, 95% CI = 1.10-1.35; (AA + GA) vs. GG: OR = 1.18, 95% CI = 1.03-1.36; (AA vs. (GA+GG): OR = 1.37, 95% CI = 1.08-1.75)), indicating that the TNF-a À308A allele might be an important risk factor for IHD. No association between other TNF-a gene polymorphisms and susceptibility to IHD were observed. No publication bias were found. Sensitivity analyses indicated that our results were stable.Conclusion: The present study indicated a possible association between the TNF-a À308G/A gene polymorphism and IHD risk. However, evidence was limited to confirm the role of TNF-a À238G/A, À857C/T, À863C/A, À1031T/C and other TNF-a gene polymorphisms in the risk of IHD.Abbreviations: CAD = coronary artery disease, CIs = confidence intervals, DALYs = disability-adjusted life years, HWE = Hardy-Weinberg equilibrium, IHD = ischemic heart disease, MHC = major histocompatibility complex, MI = myocardial infarction, NOS = Newcastle-Ottawa Quality Assessment Scale, ORs = odds ratios, SA = stable angina, TNF-a = tumor necrosis factor-alpha, UA = unstable angina.

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Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: A systematic review and meta-analysis

Cited by 33 publications

References 63 publications

Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: A case control study and meta-analysis

Role of TNF-α -308G/A gene polymorphism in gastric cancer risk: A case control study and meta-analysis

TNF-α-308/-238 polymorphisms are associated with gastric cancer: A case-control family study in China

Tumor necrosis factor-alpha gene polymorphisms and susceptibility to ischemic heart disease

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