Association between Traditional Chinese medicine and a lower risk of dementia in patients with major depression: A case-control study

Lin, Shun‐Ku; Wang, Pin-Hsuan; Huang, Ching-Hsuan; Kuo, Yu-Hsien; Wei, James Cheng‐Chung

doi:10.1016/j.jep.2021.114291

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Therefore, the TCM formulae were initially classified into three types: those tonifying the kidney (KF), those activating blood circulation (BF), and the “other TCM therapy” group. The classification standards were followed as per the classification criteria described in a previous study ( Lin et al, 2021 ). As a result, the top 20 frequently used Chinese medicine formulae in NHIRD were selected and classified into two groups: the KF and BF groups.…”

Section: Methodsmentioning

confidence: 99%

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Traditional Chinese medicine use is associated with lower risk of pneumonia in patients with systemic lupus erythematosus: a population-based retrospective cohort study

Wang

Yang

et al. 2023

Front. Pharmacol.

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Objectives: To investigate the association between traditional Chinese medicine (TCM) therapy and the risk of pneumonia in patients with systemic lupus erythematosus (SLE).Methods: This population-based control study analyzed the data retrieved from the National Health Insurance Research database in Taiwan. From a cohort of 2 million records of the 2000–2018 period, 9,714 newly diagnosed patients with SLE were initially included. 532 patients with pneumonia and 532 patients without pneumonia were matched 1:1 based on age, sex, and year of SLE diagnosis using propensity score matching. The use of TCM therapy was considered from the SLE diagnosis date to the index date and the cumulative days of TCM therapy were used to calculate the dose effect. Conditional logistic regression was used to investigate the risk of pneumonia infection. Furthermore, to explore the severity of pneumonia in SLE, sensitivity analyses were performed after stratification using the parameters of emergency room visit, admission time, and antibiotic use.Results: TCM therapy for >60 days could significantly reduce the risk of pneumonia in patients with SLE (95% CI = 0.46–0.91; p = 0.012). Stratified analysis showed that TCM use also reduced the risk of pneumonia in younger and female patients with SLE by 34% and 35%, respectively. TCM for >60 days significantly reduced the risk of pneumonia in the follow-up periods of >2, >3, >7, and >8 years. In addition, the exposure of TCM for >60 days reduced the risk of pneumonia in patients with SLE who were treated with antibiotics for moderate or severe pneumonia. Finally, the study found that using formulae to tonify the kidney for more than 90 days and formulae to activate blood circulation for less than 30 days could significantly reduce the risk of pneumonia infection in patients with SLE.Conclusion: TCM use is associated with a lower risk of pneumonia among patients with SLE.

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Section: Methodsmentioning

confidence: 99%

“…The number of days of TCM use was considered as per our previous research ( Liang et al, 2021 ; Lin et al, 2021 ). Thus, 30 days was selected as an interval, and 30, 60, and 90 days were selected to estimate the risk.…”

Section: Subgroup Analysesmentioning

confidence: 99%

Traditional Chinese medicine use is associated with lower risk of pneumonia in patients with systemic lupus erythematosus: a population-based retrospective cohort study

Wang

Yang

et al. 2023

Front. Pharmacol.

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“…The National Health Insurance Research Database (NHIRD) of Taiwan provides research data with a coverage rate of more than 99% and a tracking time of more than 12 years, making this database a suitable source for dementia prevention research. 18 , 19 …”

Section: Introductionmentioning

confidence: 99%

Acupuncture is associated with reduced dementia risk in patients with insomnia: A propensity-score-matched cohort study of real-world data

Huang

Lin

et al. 2023

Journal of Traditional and Complementary Medicine

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Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal

Acero

Ortega

Villagrasa

et al. 2023

Phytotherapy Research

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The incidence and prevalence of age‐related neurodegenerative dementias have been increasing. There is no curative therapy and conventional drug treatment can cause problems for patients. Medicinal plants traditionally used for problems associated with ageing are emerging as a therapeutic resource. The main aim is to give a proposal for use and future research based on scientific knowledge and tradition. A literature search was conducted in several searchable databases. The keywords used were related to neurodegenerative dementias, ageing and medicinal plants. Boolean operators and filters were used to focus the search. As a result, there is current clinical and preclinical scientific information on 49 species used in traditional medicine for ageing‐related problems, including neurodegenerative dementias. There are preclinical and clinical scientific evidences on their properties against protein aggregates in the central nervous system and their effects on neuroinflammation, apoptosis dysregulation, mitochondrial dysfunction, gabaergic, glutamatergic and dopaminergic systems alterations, monoamine oxidase alterations, serotonin depletion and oestrogenic protection. In conclusion, the potential therapeutic effect of the different medicinal plants depends on the type of neurodegenerative dementia and its stage of development, but more clinical and preclinical research is needed to find better, safer and more effective treatments.

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Association between Traditional Chinese medicine and a lower risk of dementia in patients with major depression: A case-control study

Cited by 4 publications

References 26 publications

Traditional Chinese medicine use is associated with lower risk of pneumonia in patients with systemic lupus erythematosus: a population-based retrospective cohort study

Traditional Chinese medicine use is associated with lower risk of pneumonia in patients with systemic lupus erythematosus: a population-based retrospective cohort study

Acupuncture is associated with reduced dementia risk in patients with insomnia: A propensity-score-matched cohort study of real-world data

Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal

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