Association Between Triglyceride Glucose Index and Non-Small Cell Lung Cancer Risk in Chinese Population

Abstract

BackgroundNumerous studies showed that insulin resistance (IR) was associated with cancer risk. However, few studies investigated the relationship between IR and non-small cell lung cancer (NSCLC). The aim of this study is to explore the association of triglyceride glucose (TyG) index, a simple surrogate marker of IR, with NSCLC risk.Methods791 histologically confirmed NSCLC cases and 787 controls were enrolled in the present study. Fasting blood glucose and triglyceride were measured. The TyG index was calculated as ln [fasting triglycerides (mg/dl) ×fasting glucose (mg/dl)/2]. Logistic regression analysis was performed to estimate the relationship between NSCLC risk and the TyG index.ResultsThe TyG index was significantly higher in patients with NSCLC than that in controls (8.42 ± 0.55 vs 8.00 ± 0.45, P < 0.01). Logistic regression analysis showed that the TyG index (OR = 3.651, 95%CI 2.461–5.417, P < 0.001) was independently associated with NSCLC risk after adjusting for conventional risk factors. In addition, a continuous rise in the incidence of NSCLC was observed along the tertiles of the TyG index (29.4 vs 53.8 vs 67.2%, P < 0.001). However, there were no differences of the TyG index in different pathological or TNM stages. In receiver operating characteristic (ROC) curve analysis, the optimal cut-off level for the TyG index to predict incident NSCLC was 8.18, and the area under the ROC curve (AUROC) was 0.713(95% CI 0.688–0.738).ConclusionsThe TyG index is significantly correlated with NSCLC risk, and it may be suitable as a predictor for NSCLC.

Association between triglyceride glucose index and risk of cancer: A meta-analysis

“…4915 relevant articles were identified initially screened from electronic databases, but only 6 articles (992292 participants) met our inclusion criteria ( Figure 1 ). These six articles included three cohort studies ( 27 , 29 , 41 ) with 862726 participants and three case-control studies ( 42 – 44 ) with 129566 participants. The detailed results are summarized in Table 1 .…”

“…Four of these studies were conducted in Asia ( 41 – 44 ), only two in Europe ( 27 , 29 ). In addition, the outcome of four studies were obesity-related cancers ( 27 , 41 , 43 , 44 ) and two were non-obesity-related cancers ( 29 , 42 ). The risk of bias within included literature were evaluated via the NOS ( Tables 1 ; S3 ).…”

A novel nutritional score based on serum triglyceride and protein levels predicts outcomes of intrahepatic cholangiocarcinoma after curative hepatectomy: A multi-center study of 631 patients

“…In 1991, elevated serum TG level was reported to be associated with a higher incidence of developing breast cancer ( 33 ). In the male population, fasting TG and glucose levels were significantly correlated with the risk of non-small-cell lung cancer ( 34 ). In a large cohort study involving 1,56,153 participants in Austria, serum TG concentration was found to be positively or reversely associated with multiple malignancies ( 13 ).…”

Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank

“…However, very few studies have examined the association between the TyG index and lung cancer. A recent study reported that the TyG index is remarkably higher in patients with non-small cell lung cancer than in controls in a Chinese population ( 16 ). Consequently, the TyG index may be a suitable tumor marker for non-small cell lung cancer.…”

“…Although some previous studies have preliminarily examined the relationship between IR and lung cancer, the evidence is unconvincing and somewhat controversial. Several studies have shown that IR is positively related to lung cancer, whereas some studies found an invalid association (13)(14)(15)(16)(17). In addition, most of the literature had a small sample size and insufficient estimates of genetic predisposition.…”