Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection

Xu, Xiao-Ping; Lu, Min-qiang; Tan, Deming

doi:10.1111/j.1469-0691.2004.01029.x

Cited by 40 publications

(32 citation statements)

References 15 publications

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“…Nonetheless, he found that the haplotype -308 G/ -238 G was associated with HBV persistence. On the other hand, Xu et al (2005) verified a higher frequency of both, TNF -308 GA and the allele A in chronic patients with severe disease in relation to controls, asymptomatic patients and patients with mild disease. Nevertheless, they did not see any difference between chronic patients, as a single group, and controls.…”

Section: Discussionmentioning

confidence: 80%

Association of cytokine genetic polymorphism with hepatites B infection evolution in adult patients

Ribeiro

Visentainer

Moliterno

2007

Mem. Inst. Oswaldo Cruz

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in a lower frequency in chronic patients than in individuals with P = 0.079; OR = 0.40;. In chronic patients with histological alterations it was not observed the genotype TGFB1+869 C/C, against 24.4% in the self limited infection group (100 versus 75.6%; P = 0.096; OR = 7.67; . Further studies in other populations, and evaluation of a greater number of individuals could contribute for a better understanding of the cytokine genetic polymorphism influence in HBV infection evolution. Key words: cytokine gene polymorphism -hepatitis B -genetic associationThe infection by the hepatitis B virus (HBV) appears under different forms of evolution, ranging from the asymptomatic and self-limited infection to the chronic state, which can develop into chronic hepatitis, cirrhosis, and hepatic-cellular carcinoma (Thomas & Strickland 2000). It is estimated that the virus infected 350 million people in the whole world, forming a reservoir which facilitates the spreading of the disease (Kane 1995). Furthermore, in spite of the transmission reduction after the vaccination advent (Shih et al. 1999, BerliozArthaud et al. 2003, the infection remains as an important cause of chronic hepatic disease (Thomas & Strickland 2000).The Health Ministry estimates that 1% of the Brazilian population has chronic diseases related to HBV (Ministério da Saúde 2003, Ferreira 2004. The factors that lead a patient with acute infection by HBV to become persistently infected are not totally established. Environmental factors as well as factors innate to the virus do not completely explain the different forms of the HBV infection evolution (Chu & Lok 2002, Kao et al. 2002, bringing up a discussion of the implication of genetic factors in disease evolution (Thio et al. 1999, Thursz 2001.The initial anti-HBV immune response promotes the killing of infected cells by the virus and the secretion of antiviral cytokines by cells of the innate immunity (Ferrari et al. 2003). However, the infection control is not reached at this stage of HBV response. A vigorous and polyclonal immune response of T cells is pointed out as fundamental for the virus elimination and disease resolution (Guidotti et al. 1999). The well-successful response to HBV is a result of both specific anti-virus cytotoxic T-cells activity, which eliminates the infected cells, and non-cytolitic mechanisms exerted through cytokines released by T and non-T cell infiltrates. The cytokines are able to suppress the viral expression and replication, mediating the infection control without causing death of the infected cell. The evolution of the infection to chronicity is associated to a weak or undetectable humoral immune response, and is identified by the persistency of HBV's surface antigen (HBsAg) in the circulation (Jung & Pape 2002, Ferrari et al. 2003.Several studies have evaluated the influence of genetic factors in the cytokine production by cells of the immune system. The genetic polymorphism was pointed out because it correlates to both the transcription level and in vitro production of tu...

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Section: Discussionmentioning

confidence: 80%

Association of cytokine genetic polymorphism with hepatites B infection evolution in adult patients

Ribeiro

Visentainer

Moliterno

2007

Mem. Inst. Oswaldo Cruz

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“…In specific, the importance of cytokines such as TNF-a, which acts as a potent pro-inflammatory cytokine for the clearance of viral infection, has been highlighted for many years [18], and numerous studies have been conducted to identify polymorphisms of TNF-a promoters that affect susceptibility to persistent HBV infection [16,19,20]. Of the various polymorphisms, those at positions -308 and -238 are the most well-studied targets [10][11][12][13][14][15]. Until today, however, no analysis has been performed on the relationship between polymorphisms of TNF-a promoters and outcomes of HBV treatment with antiviral agents.…”

Section: Discussionmentioning

confidence: 99%

“…Among the various single nucleotide polymorphisms (SNPs) in the TNF-a promoter region, -238 G to A and -308 G to A polymorphisms were vigorously investigated [10][11][12][13][14][15]. Although the results were not consistent, it was notable that TNF-a promoter -238 G to A polymorphism was associated with chronic hepatitis B and progression of HBV infection [10,13,15], and that -308 G to A polymorphism was associated with HBV clearance and antibody production [11].…”

Section: Introductionmentioning

confidence: 99%

Association Between Polymorphism of Tumor Necrosis Factor-α Promoter and Response to Lamivudine Treatment in Patients with Chronic Hepatitis B

et al. 2009

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“…The diagnoses were complied with the diagnostic criteria of the 2000 Xi'an Viral Hepatitis Management Scheme issued by the Chinese Society of Infectious Diseases and Parasitology, and the Chinese Society of Hepatology, of the Chinese Medical Association (36). The standards for diagnoses of AHB, CHB, and CSHB have been described in detail previously (37,38). Briefly, AHB patients are defined as those who displayed hepatitis B surface Ag (HBsAg)-negative conversion within 6 mo after the initial onset of symptoms due to HBV infection.…”

Section: Subjectsmentioning

confidence: 99%

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

Jin

et al. 2006

The Journal of Immunology

407

363

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CD4+CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance against self and foreign Ags, but their role in persistent viral infection has not been well-defined. In this study, we investigated whether and where CD4+CD25+ Treg contribute to the development of chronic hepatitis B (CHB). One hundred twenty-one patients were enrolled, including 16 patients with acute hepatitis B, 76 with CHB, and 29 with chronic severe hepatitis B. We demonstrated that in chronic severe hepatitis B patients, the frequencies of CD4+CD25+ Treg in both PBMC and liver-infiltrating lymphocytes were significantly increased and there was a dramatic increase of FoxP3+-cell and inflammatory cell infiltration in the liver compared with healthy controls. In CHB patients, circulating CD4+CD25+ Treg frequency significantly correlates with serum viral load. In acute hepatitis B patients, circulating CD4+CD25+ Treg frequency was initially low and with time, the profile reversed to exhibit an increased number of circulating Treg in the convalescent phase and restored to normal levels upon resolution. In PBMC taken from infected patients, depletion of CD4+CD25+ Treg led to an increase of IFN-γ production by HBV-Ag-stimulated PBMC. In addition, CD4+CD25+ Treg were capable of suppressing proliferation of autologous PBMC mediated by HBV Ags, which probably reflects the generation of HBV-Ag-specific Treg in circulation and in the liver of HBV-infected patients. Together, our findings suggest that CD4+CD25+ Treg play an active role not only in modulating effectors of immune response to HBV infection, but also in influencing the disease prognosis in patients with hepatitis B.

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Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection

Cited by 40 publications

References 15 publications

Association of cytokine genetic polymorphism with hepatites B infection evolution in adult patients

Association of cytokine genetic polymorphism with hepatites B infection evolution in adult patients

Association Between Polymorphism of Tumor Necrosis Factor-α Promoter and Response to Lamivudine Treatment in Patients with Chronic Hepatitis B

Circulating and Liver Resident CD4+CD25+ Regulatory T Cells Actively Influence the Antiviral Immune Response and Disease Progression in Patients with Hepatitis B

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